Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 49 for “"systems neuroscience"”.
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Strong and weak principles of Bayesian machine learning for systems neuroscience
… machine learning and its applications to neuroscience, highlighting how both the strong and weak approaches have improved our understanding of neural computations in recent years. We then develop several new models in this field, which provide insights into neural computations ranging from …
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C. elegans as a Platform for Multimodal Neural Data Integration
Systems neuroscience has traditionally been fragmented into investigations at discrete levels of organization, creating methodological and conceptual gaps that hinder unified understanding of neural function. This thesis examines the nematode Caenorhabditis elegans as a platform for integrating …
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Development of Optical Tools and Techniques Toward a Functional Connectomic Understanding of C. elegans
… that can push the field of C. elegans systems neuroscience towards a functional connectomic understanding of the neural control of the animal’s behavior.
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Computational Principles of Brain Network Development
… backdrop to the field of developmental systems neuroscience, I introduce generative network models. These relatively new family of models are capable of simulating probabilistic network development. The basis for these models includes simple sets of wiring rules, existing within various …
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Perceptual and cognitive influences on decision making and the activity of single neurons in the superior colliculus and frontal eye field
… Perceptual decision making is a field within systems neuroscience that aims to resolve how this process unfolds. In contrast to choice behavior and decision making in general, which are closely related concepts traditionally studied by psychologists, behavioral ecologists, and economists, …
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Brain circuits for the representation of subjective reward value
… in this process remains an important goal in systems neuroscience. However, little is known about the neural circuits that compute, or represent, low level primary reward signals. We have combined quantitative psychophysical measures of subjective reward magnitude elicited by rewarding …
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Probing the depths of unconsciousness with multifunctional neurotechnology
… This thesis focuses on how the intersection of neuroscience, engineering, and statistics can be leveraged to unravel the mechanisms behind altered consciousness induced by high-dose ketamine. Although ketamine has been indispensable to medical practice since 1970, the neurobiological mechanisms …
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Optogenetic Interrogation of Primary Visual Cortex and Its Impact On Neural Coding and Behavior
… experiences is one of the great mysteries of systems neuroscience. Undoubtedly this involves the activity of large populations of interconnected neurons, but while the responses of individual neurons to a variety of sensory stimuli have been well-characterized, how <em>populations</em> of such …
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Neural Dynamics, Adaptive Computations, and Sensory Invariance in an Olfactory System
… time in the early processing stages of olfactory systems. What features of these spatiotemporal neural response patterns encode stimulus-specific information (i.e. ‘neural code’), and how they are translated to generate behavioral output are fundamental questions in systems neuroscience. The …
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Models of neural circuits as optimally driven dynamical systems
… years have seen increased interest from the neuroscience community in modelling neuronal populations through the lens of dynamical systems. However, most recordings are performed in one or a small subset of brain areas, such that the underlying dynamics do not come from an isolated system, …
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Dynamic speech networks in the brain: Dual contribution of incrementality and constraints in access to semantics
… E/MEG experiments I address two core issues in systems neuroscience of language: 1) What are the network dynamics underpinning cognitive computations that take place when we map sounds to rich semantic representations? 2) How do the prior semantic and syntactic contextual constraints facilitate …
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Dissection of Neurons and Circuits Involved in Regulating Innate Behaviors, Movement and Higher Cognitive Functions in Mice
… influence behavior is a fundamental tenet of Systems Neuroscience. Advancements in this field are critical to help us understand the inner workings of our brains, and eventually who we are as humans. Describing the physiologic functioning of neural circuits is also necessary to recognize their …
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Elucidating the Principles of Brain Network Organisation through Neurosurgery
… leaders in human brain mapping and the clinical neurosciences outlined the need for prospective trials in neurosurgery to establish the clinical relevance of connectomics. This doctoral dissertation addresses this challenge by using diffuse gliomas as a model to study the principles of brain …
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The Functional Role of Anatomical Feedback Connections In Visual Attention
… vastly different anatomy between the two model systems. Recent technological advancements now allow nonhuman primate researchers to leverage the optogenetic methods commonly used in mouse models, providing an experimental design to specifically test the functional role of feedback in visual …
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Causal control of the thalamic reticular nucleus using optogenetic and novel chemogenetic approaches
… has rapidly become a standard technique in systems neuroscience, and its genetic specificity and rapid development of new compounds has revolutionized our ability to causally manipulate neural circuits. While the use of light to drive cellular reactions brings a number of advantages when …
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Neural dynamics supporting flexible cognition
<p>Flexible cognition enables humans to adapt their behavior to changing circumstances by prioritizing relevant information and filtering out distractions. This process is thought to be supported by the integration of ongoing behavioral goals with incoming sensory information, but how this …
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Investigating The Neural Basis of Audiovisual Speech Perception With Intracranial Recordings In Humans
<p>Speech is inherently multisensory, containing auditory information from the voice and visual information from the mouth movements of the talker. Hearing the voice is usually sufficient to understand speech, however in noisy environments or when audition is impaired due to aging or disabilities, …
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The Physiology of Dementia: Network reorganisation in progressive non-fluent aphasia as a model of neurodegeneration
… chapters, and explain how I have applied a systems identification framework to a diverse set of experimental methods, with the common goal of defining the physiology of dementia. I then return to the results of chapter 3 with a clinical focus to explain how inflexible predictions can account …
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Lateralized Temporal Integration Properties of the Mouse Auditory Cortex
<p>Social communication calls are fleeting, rapidly modulating signals and the ability of the auditory system to perceive such transient signals is a remarkable phenomenon. The mechanism by which the auditory cortex (ACx) is believed to be capable of processing these signals is through recurrent …
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Effects of Resting State On Perceptual Learning
<p>Psychophysical experiments in humans have demonstrated that improvements in perceptual learning tasks occur following daytime rests. The neural correlates of how rest influences subsequent sensory processing during these tasks remain unclear. One possible neural mechanism that may underlie this …
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