Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 197 for “"systems level"”.
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A Systems-Level Analysis of Algorithmic Regulation
… lagging in mitigating the impacts of algorithmic systems. In this thesis, I characterize and evaluate the systemic relationship between regulation and algorithmic technologies in two parts. In Part I, I uncover the current mismatched application of laws to algorithmic systems and propose resulting …
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Business case assessment of unmanned systems level of autonomy
The federal government has continually increased its spending on unmanned aerial vehicles (UAVs) during the past decade. Efforts to drive down UAV costs have primarily focused on the physical characteristics of the UAV, such as weight, size, and shape. Due to the saturation of the UAV business in …
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Systems-level analysis of On Demand Mobility for aviation
… near and far-term mitigation opportunities. A systems-level analysis was used to capture interdisciplinary influence factors such as limitations placed on ODM networks as a result of air traffic control, ground infrastructure integration, network load balancing, unmanned aircraft interaction …
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Phytohormonal regulation of Solanum lycopersicum development at the systems level
Plant growth, development, and environmental adaptation are orchestrated by an intricate network of phytohormone pathways. These pathways, while often studied individually, operate as an interconnected system, the phytohormone system, whose emergent properties cannot be fully understood through …
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Retaining Novice Nurse Practitioners: Advancing A Systems Level Professional Preceptor Model
<p>The transition from Registered Nurse (RN) to Nurse Practitioner (NP) has several barriers and is complicated by role strain and loss of confidence. Novice turnover rates can be over 30%. Evidence suggests that supportive onboarding is critical to advanced practice clinician (APC) job …
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Assessing Public Health Preparedness in Alberta Using a Systems-Level Approach
… metropolitan, regional, provincial, and federal levels is essential to the management of public health emergencies. The level of inter-organizational coordination and preparedness of public health and emergency preparedness organizations throughout Alberta was investigated. An online …
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Virtual bioinstrumentation: Integrating biomedical experimentation with systems-level modeling and analysis
… function of the cardiovascular and pulmonary systems. The use of parameter estimation schemes makes the results of these studies relevant to individual subjects being tested. These innovative applications create a robust, user-friendly environment that enables the models developed to be used …
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Specific bio-modeling and analysis techniques at cellular and systems level
… approaches are developed for two different levels, cellular (Part I) and systems (Part II), and used to develop insights into system performance. PART I consists of three chapters focusing on computational neuroscience models at cellular level. The mechanisms of action of a drug on …
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Systems-level design of ion transport membrane oxy-combustion power plants
… a tool for the analysis and design of ITM systems. The ITM model is used to explore the dependence of ITM performance on reactor geometric structure, flow configuration, operating conditions, membrane material properties, and uncertainty in key modeling assumptions. Many operational …
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Systems level approach to process improvement initiatives in a semiconductor manufacturing environment
Many successful companies have difficulty implementing large-scale change initiatives such as Lean, Six Sigma, outsourcing or Advanced Process Control. This can often be due to the fact that they treat large-scale improvement efforts in the same way that they handle smaller improvement efforts. …
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Systems level investigation of the genetic basis of bovine muscle growth and development
Skeletal muscle growth is an economically and biologically important trait for livestock raised for meat production. As such, there is great interest in understanding the underlying genomic architecture influencing muscle growth and development. In spite of this, relatively little is known about …
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Actin Regulatory Dynamics Required for T Cell Activation: A Quantitative and Systems-Level Perspective
… call ‘spatiotemporal patterning’. We performed a systems-scale analysis of the spatiotemporal patterning of T cell signaling and have found that it is highly diverse. Over 50 signaling sensors were imaged in live primary T cells activated with APCs under various physiological stimulation …
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Molecular and systems-level analyses reveal the emerging role of non-coding RNAs in liver diseases
… expression at transcriptional or translational levels. Ample studies have revealed that the aberrant levels of miRNAs strongly correlate with the pathogenesis of metabolic diseases. In addition, long non-coding RNAs (lncRNAs) have been regarded as co-operators of miRNAs, involving in the …
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Systems level characterizations of single and combination drug mechanisms of action in vitro and in vivo
Small molecule characterization is a critical limiting step in cancer drug development. At the present time, high throughput screens of natural products and combinatorial synthesis libraries generate more pharmaceutical leads than can be characterized in detail. Lead optimization further generates …
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Massachusetts Institute of Technology--a systems-level analysis and vision for the future : (the Grand Plan)
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Aeronautics and Astronautics, 1995.
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Using biological and chemical information to improve understanding of drug mechanism of action on the systems-level
… gain insights on compound MoA across different levels of biology. This presents an opportunity to investigate approaches for integrating information sources and computational methods for the elucidation of a systems-level view of compound MoA, which is the topic of this thesis. In the first …
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A systems-level analysis of dynamic reprogramming of RNA modifications in the translational control of cellular responses
… non-coding RNAs suggested the possibility of systems behavior of RNA modifications in translational facets of cellular responses. The studies presented in this thesis utilize a quantitative systems-level approach to test the hypothesis that the spectrum of tRNA modifications represents a …
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The Transition to Kindergarten for Autistic Children: A Three-Part Study Examining Systems Level Influences on the Transition
… process and present opportunities to bolster the systems that support marginalized autistic children and their families during this process.
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