Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"systems immunology"”.
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Systems Immunology Approaches for Precision Medicine
… I present three studies highlighting phases of a systems immunology cycle. Firstly, the thesis provides a description of the construction of a computational ordinary differential equation based model on the host-pathogen-microbiota interactions during Clostridium difficile infection and the use of …
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Characterization of Regulatory Mechanisms in Mucosal Immunity by Systems Immunology
The mucosal immunity of the gastrointestinal (GI) tract is constituted by a complex, highly specialized and dynamic system of immune components that aim to protect the gut from external threats. The sustained exposure of the mucosal immune system of the GI tract to an enormous number of lumen …
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Systems immunology frameworks link multicellular immune perturbation phenotypes and setpoints to response outcomes
… thesis develops frameworks for using top-down systems biology approaches with multiomic single cell technology to understand variation in human immune system response outcomes. We integrate human population, cell subset and single cell variations in molecular phenotypes which give rise to …
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Leveraging Systems Immunology To Understand The Molecular Underpinnings Of Chimeric Antigen Receptor T-Cell Therapy
… advances in the field of genomics and systems biology, including approaches to capture and analyze RNA expression, protein expression, and chromatin accessibility at a single-cell resolution. In this dissertation, I investigate the molecular basis of CAR T-cell therapy response and …
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Data-driven and Machine Learning approaches for exploration and inference of Biological Pathways in physiological and pathological states
… and broad applicability of pathways across systems biology, there is scope for improvement regarding their comprehensiveness and quality. Previous work has shown that they are incomplete and inconsistent. In support of this view, here I show that pathway databases are not yet sufficiently …
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Understanding the Effects of Ageing on B cells Response to Vaccination
… response among older people, I employed a systems immunology approach to investigate the molecular pathways and cellular populations associated with antibody responses to seasonal flu vaccination in individuals aged above 64 years old. Although bulk RNA sequencing analysis of …