Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 32 for “"systemic treatment"”.
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Determinants of systemic treatment response in atopic dermatitis
… targeted therapies, predictors of individual treatment response remain poorly defined. This thesis investigates systemic therapies for AD by integrating real-world registry data, clinical trials, and molecular skin analyses. First, data from the TREATgermany registry were used to compare …
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Centralised Preparation of Medicinal Products for Systemic Treatment of Malignant Diseases in Hospital Pharmacies in Bulgaria – Specifics, Challenges and Prospects // Централизирано разтваряне на лекарствени продукти за системно лечение на злокачествени заболявания в болничните аптеки в България – специфики, предизвикателства и перспективи
… preparation of medicinal products for systemic treatment of malignant diseases in Bulgaria was made at the end of 2015, and there is no regulatory document that specifies exactly what competencies are required to perform it. The purpose of this thesis is to study and analyse the process …
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Mutiple systems training for treatment of incest : effects on attribution of blame
… experience, based upon a multiple systems incest treatment model, would reduce attribution of incest blame. As increasing numbers of persons seek treatment for incestuous experiences, trained professionals will be needed who understand the complexities of incest and the impact of attributing …
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Do Calcium and Vitamin D Levels in Blood Predict Clinical Features and/or Response to Treatment in People with Psoriasis?
… relapses and remissions. The selection of treatment of psoriasis is dependent on the psoriasis type, impact on the individual and the severity of the disease. Variable factors that remain incompletely understood influence response to systemic treatment. It is of interest to establish …
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SYNTHESIS AND SCREENING OF PI3K INHIBITOR PRODRUGS FOR TREATMENT OF PROSTATE CANCER
… men. At the current time, there is no effective treatment for men with metastatic prostate cancer. Androgen ablation is the most successful systemic treatment for prostate cancer. However, the cancer eventually recurs as androgen-independent prostate cancer. Phosphoinositide 3-kinases (PI3Ks) are …
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The Role of Membrane-Bound Receptors in the Rapid Estrogenic Enhancements of Learning and Memory Within the Hippocampus
… in learning and memory on a rapid time scale. Systemic treatment with 17β-estradiol rapidly improves object recognition, social recognition and object place learning in ovariectomized female mice within a timescale of only 40 minutes following administration. Studies have identified the dorsal …
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Novel Drug Discovery for Glioblastoma Multiforme Using Brain Tumour Initiating Cells
… potential of diverse BTIC lines. In vivo, systemic treatment with R348, the prodrug form of R333, was well tolerated and demonstrated favourable pharmacokinetic properties. R348 treatment was also found to lead to a significant increase in overall median survival in an orthotopic BTIC …
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THERMOSTABLE EXOSHELLS AS TOOLS FOR RECOMBINANT PROTEIN EXPRESSION AND IN VIVO DELIVERY
… uptake of the enzyme into MDA-MB-231 and systemic treatment with IAA in the presence of locally administered tES(+)/tES-HRP results in complete tumor regression. Our findings support the potential use of thermostable shells in the therapeutic delivery of macroglobular proteins.
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Molekuliniai ir klinikiniai inkstų vėžio prognozės rodikliai /
… that can help the urologist choose the right treatment tactics.The work evaluated the predictive value of epigenetic markers in determining aggressive forms of kidney cancer and predicting rapid tumor growth.To our knowledge, this study is the first to analyze DNA methylation in urine samples …
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Straight from the source's mouth? : The 1997 alternative federal budget and the neo-liberal discourse of economy in mainstream news media reportage
… or institutional "bias" while overlooking the systemic treatment of social movements. What is more, a blindspot becomes apparent when spaces do open up for oppositional voices. Such is the case for the Canadian Centre For Policy Alternatives and the 1997 Alternative Federal Budget. The question …
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Targeted drug delivery by novel polymer-drug conjugates containing linkers cleavable by disease-associated enzymes
… to achieve targeted drug delivery for the systemic treatment of cancer and other inflammatory diseases. The physiochemical properties of the polymer allow the conjugate to circulate longer in the body by minimizing renal and hepatic clearance, thereby improving the pharmacokinetics of the …
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OTULIN's Novel Regulatory Mechanisms in Genotoxic and Inflammatory NF-kB Signaling
… due to the lack of a target. Chemotherapy is a systemic treatment that works by attacking rapidly growing cells, which is initially more effective for TNBC patients than those individuals with the hormone receptor-positive breast cancer. However, patients with TNBC tend to develop resistance to …
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A Theoretical Model Of Breast Tumor Metastases In The Context Of Tumor Dormancy
… is at a size that does not normally warrant a systemic treatment. Current breast cancer models developed as part of the Cancer Intervention and Surveillance Modeling Network (CISNET) consortium assume that metastasis is a late event when estimating the benefits of cancer control strategies in …
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Stenotrophomonas maltophilia induzierte Endophthalmitis
… (PE) world-wide. We present characteristics, treatment and outcome in 26 cases of PE caused by S. maltophilia contaminated rinsing solution used during cataract surgery. Methods: 21/26 patients (81%) required pars plana vitrectomy and were treated with intravitreal, topical, subconjunctival …
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Perceived Need of Directors for Family Therapy-Related Services in a Child Care or Preschool Setting
… therapists as trained professionals who focus on systemic treatment of the family as a whole unit, 3) Less than half of the participants currently offer on-site mental health services, 4) While it seems that participants routinely refer parents to and consult with mental health providers, they are …
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The effects of gene replacement therapy on respiratory and gait function in a canine model of X-linked myotubular myopathy
… hindlimb, isolated perfusion of the hindlimb and systemically. Systemic treatment was carried out at three different doses to determine the minimum effective dose for full preservation of function. Respiratory function and ambulation were measured in these dogs and compared to untreated and normal …
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The medial prefrontal cortex and the dorsomedial striatum are necessary for working memory in rats: role of NMDA receptors
… correct response. Results obtained following systemic treatment of rats with a broad spectrum NMDA receptor antagonist showed that NMDA receptors contribute to performance of both tasks. Given the contribution of cortical GluN2B-containing NMDA receptors to working memory in primates, we …
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Investigation of novel topical therapeutics for chronic rhinosinusitis
… of the host immune responses. First-line treatments are saline nasal irrigation and topical corticosteroids, with the addition of courses of systemic antibiotics and corticosteroids when indicated. If these therapies do not yield a satisfactory improvement in symptoms, functional …
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Suicide Gene therapy for Malignant Gilomas using Neural Stem Cells
… Here, author investigated the possibility of treatment for the malignant gliomas with neural stem cell (HB1.F3) transduced with suicidal gene using the tropism of stem cells. MATERIALS AND METHODS: E.coli cytosine deaminase(CD) of suicide gene is enzyme that catalyzes the conversion of …
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Treatment pathways and economic analysis of treatment for severe psoriasis
… disease usually requires photochemotherapy or systemic treatment. Information about the effectiveness, safety and costs of the different treatments is required to enable dermatologists to formulate evidence-based treatment guidelines. Systematic reviews of the four main treatment modalities for …
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