Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"systemic infection"”.
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Characterising the immune response to Salmonella and Salmonella surface antigens during a systemic infection
… and humoral immunity at different stages of infection. In infants in sub-Saharan Africa infection with non-typhoidal Salmonella (NTS), such as STm, can commonly cause fatal invasive disease. Evidence indicates that disease may be preventable by antibody, which makes vaccine development …
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Pleiotropic regulatory function of the lysr family transcriptional regulator cpsy during streptococcus iniae systemic infection
… of cpsY is highly attenuated in a zebrafish infection model. The cpsY deletion mutant displays a methionine-independent growth defect in serum, which differs from the methionine-dependent defect observed for orthologous mutants of <i>S. mutans</i> and <i>S. agalactiae</i>. On the contrary, …
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Blood-Derived Plasminogen Modulates the Neuroimmune Response in Both Alzheimer's Disease and Systemic Infection Models
… factors associated with an increase in systemic infection have been linked to a risk of AD development and progression. However, the link between vascular risk factors, systemic inflammation, and the neuroinflammation characteristic of AD are not fully understood. Plasminogen is …
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Molecular characterisation of the role of systemic infections in Alzheimer’s disease brain
… glial activation, vascular dysfunction, and systemic influences. This thesis investigates how systemic infection reshapes the molecular architecture of the AD brain and introduces Genedex, a framework to contextualise transcriptional findings within the broader AD continuum. Using post-mortem …
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Survival of Salmonella in the macrophage phagosome
… via the fecal-oral route, S. Typhimurium infection typically results in self-limiting gastroenteritis. However, in immunocompromised patients, Salmonella can invade the gut epithelial barrier and cause systemic infection resulting in septicemia and lethal infection. Key to establishment of …
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Immunomodulatory Effect Of Host And Fungal Eicosanoids During Host-Pathogen Interactions With Candida Albicans
… with this fungus ranges from superficial mucosal infection to life-threatening systemic candidiasis. The mechanisms by which Candida persists at mucosal surfaces in the face of an adaptive response are unclear. Candida produces immunomodulatory oxylipins that cross-react functionally with host …
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SRV REGULATION OF STREPTOCOCCAL BIOFILM DISPERSAL AND ITS IMPACT ON VIRULENCE
… human pathogen that commonly causes mild skin infections. However, GAS also causes severe infections including necrotizing fasciitis. The mechanism for triggering the switch between mild and severe disease has yet to be discovered. Several groups have shown that regulation of protease …
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Tumor Necrosis Factor-α Production By Murine Peritoneal Macrophages in Response to Candida Albicans Yeasts, Germ Tubes, and Mycelia
… to cause lethal septic shock and disseminated infection in immunocrompromised hosts. Following colonization of the hosts tissues the yeast form of the organism forms germ tubes and eventually mycelia. The yeast form of the organism is enerally associated with the commensal organism and the …
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Tamarillo mosaic potyvirus: characterization and resistance
… plant lines demonstrated resistance to virus infection (more than 10% of resistant plants/line). All plants of one line, PT#25, were resistant to TaMV infection using dilute inocula; 40% were also resistant after inoculation with more concentrated inocula. The level of accumulation of CP in …
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Antigenic Characterization of <I>Haemophilus somnus</I> Lipooligosaccharide
… LOS. How PCho negative variants could allow for systemic infection after initial colonization of the mucosa by PCho positive variants is discussed.
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Role of entF Gene in Iron Acquisition by Brucella abortus 2308
… causes undulant fever in humans and uterine and systemic infection leading to abortions in domestic animals and wild life. For the acquisition of iron in mammalian hosts, species of Brucella are known to produce two siderophores, 2, 3-dihydroxy benzoic acid (2, 3-DHBA) and brucebactin. Inability …
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Mechanisms of anaerobic nitric oxide detoxification by Salmonella enterica serovar Typhimurium
… the cause of millions of food- and water-borne infections worldwide. Systemic infection and gastroenteritis are the main diseases and often prove fatal to immunocompromised patients. Key to Salmonella’s pathogenicity is the survival of several components of the innate immune system encountered …
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Cellular Functions of the Squash Leaf Curl Geminivirus Movement Proteins BL1 and BR1
… virus to the phloem and eventually leading to systemic infection of the plant. Unlike most plant viruses squash leaf curl geminivirus (SqLCV) encodes two movement proteins termed BR1 and BL1. This is most likely due to the fact that SqLCV is a ssDNA virus and must replicate in the nucleus, …
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Identification and characterization of host genes involved in regulating replication of brome mosaic virus
… Pathogenesis-Related genes 5) mutant can support systemic infection of BMV. I performed screens in Arabidopsis and have identified four genes that contribute to defense against BMV. These include two RNA-binding proteins, a lectin superfamily protein, and an alternative oxidase. My results also …
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ANIMAL MODELS FOR BEHAVIORAL CHANGES OR HEARING LOSS UPON ACUTE VIRUS INFECTIONS
… loss, and hearing loss. Although many viral infections may lead to sequelae, two genera of single stranded RNA viruses are of high importance to study as models of neurological sequelae; arenaviruses and alphaviruses. Both of these viruses are important human pathogens and the cause of the …
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Use of transgenic mice to study the role of autophagy protein ATG16L1 in Crohn’s Disease
… in defective defence against bacterial infections. We hypothesise that autophagy defects caused by mutations in ATG16L1 prevent effective clearance of pathogens and/or pathobionts by xenophagy, resulting in a persistent infection and overt inflammation. To address this question we …
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Cortisol perturbation in the pathophysiology of septicaemia, complicated pregnancy and weight loss/obesity.
… threatening condition that complicates severe infection and is characterized by systemic inflammation and refractory hypotension. High plasma total cortisol levels and attenuated responses to synthetic ACTH stimulation are associated with increased mortality. The use of corticosteroids in …
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Early Events Following Oral Transmission of Simian Immunodeficiency Virus: From Viral Entry to Host Immune Response
… with SIV and necropsied at early times post-infection (days 1 - 14). These studies were the first to identify the preferential entry sites for the virus as the oral and esophageal mucosa, as well as the tonsils. Furthermore, SIV rapidly disseminated to peripheral lymph nodes resulting in …
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CcpA-Mediated Carbon Catabolite Repression of Virulence in the Group A Streptoccus
… phenotype in the absence of CcpA using two mouse infection models. Microarray analysis of the delta ccpA strain determined that CcpA significantly represses the expression of saga, the gene encoding the potent cytolysin, streptolysin S (SLS). Moreover, hemolytic activity due to SLS was increased …
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Mechanisms of Immuno-Modulation With The TLR4 Agonist Monophosphoryl Lipid A in the Treatment of Sepsis
… MPLA treatment on the innate immune response to systemic infection in mice with emphasis on bacterial clearance, leukocyte recruitment and function, as well as potential signaling pathways involved in TLR4 immmuno-modulation. Mice received either intravenous or intraperitoneal treatment with MPLA …
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