Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"system biology"”.
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Assessing computational methods and science policy in systems biology
In this thesis, I discuss the development of systems biology and issues in the progression of this science discipline. Traditional molecular biology has been driven by reductionism with the belief that breaking down a biological system into the fundamental biomolecular components will elucidate …
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Integration of Genome Scale Data for Identifying New Biomarkers in Colon Cancer: Integrated Analysis of Transcriptomics and Epigenomics Data from High Throughput Technologies in Order to Identifying New Biomarkers Genes for Personalised Targeted Therapies for Patients Suffering from Colon Cancer
… mechanisms leading to colorectal cancer. A systematical review of the literature is conducted on Microarray Gene expression profiling, gene ontology enrichment analysis, microRNA and system Biology and various bioinformatics tools. We aimed this study to stratify a colon tumour into …
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Computational Analysis of LC-MS/MS Data for Metabolite Identification
… quantitation of metabolites within a biological system. As the most direct representation of phenotypic changes, metabolomics is an important component in system biology research. Recent development on high-resolution, high-accuracy mass spectrometers enables the simultaneous study of hundreds or …
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Deep Generative Models and Biological Applications
… Turing pattern PDEs generation in synthetic/system biology, and automatic cardiovascular disease detection in medical imaging processing.</p>
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The elucidation of immunological and oncological transcriptomic signatures using translational ontologies and next-generation sequencing
… the role of Foxp3 architecture in immune system biology. These methods will then be framed in the context of broader biological and clinical applications. From these oncological and immunological analyses, a “central dogma” of transcriptomic expression patterns can be derived. In chapter …
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Machine Learning Methods for Decision Making Inference in Healthcare
… 5, I extend a previously developed dynamic systems inference method (Manifold Approximated Gaussian Process Inference) to situations with completely unknown systems dynamics, with applications in system biology and other scientific areas.
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Engineering a synthetic p53-Mdm2 network in budding yeast
… is extremely intricate and complex, and from a system biology point of view it can be seen as a series of interconnected negative and positive feedback loops, which can give rise to complex dynamics such as oscillations. In the combined effort to understand more of the biological meaning of …
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Pesticide regulatory actions and the development of pest resistance: a dynamic bioeconomic model
… to represent the U.S. apple production system. Information generated through optimization of the dynamic bioeconomic model suggested that resistance becomes quantitatively important when planning horizons exceed 10 years, confirming that the economic performance of the production system …
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A STUDY ON THE BIOCHEMICAL AND CELLULAR EFFECTS OF ENVIORMENTAL TOBACCO SMOKE ON ADULT AND DEVELOPING RAT BRAIN BIOCHEMISTRY
… effects on developing cerebellum using a system biology approach involving mass spectrometry (MS). Proteins at statistically different abundance between groups were correlated with relevant biochemical processes and pathways by bioinformatics. ETS responsive data were enriched in elements …
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Signal-metabolome interactions in plants
… for the comprehensive description of biological systems. Multi-selective methods that aim to cover as many endogenous compounds as possible in biological samples use different analytical platforms and include methods like gene expression profile and metabolite profile analysis. The enormous …
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INVESTIGATING IMMUNE SYSTEM REGULATION THROUGH CROSS-DISEASE GENETIC ANALYSIS AND B CELL FATE DECISIONS
… gastrointestinal tract diseases, rheumatic and systemic diseases, and allergic diseases. Surprisingly, only 5% of the susceptibility genomic regions were shared among the groups, suggesting that the three latent structures were driven by different genetic components. I then sought to link the …
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ESTABLISHING IN VITRO INTESTINAL EPITHELIAL CELL MODELS IN TRANSLATIONAL ANIMAL NUTRITION
… sulphate sodium (DSS). In addition, through system biology and multi-omics integration (transcriptomics and proteomics), we have demonstrated the cytoprotective properties of n-3 PUFA in IPEC-J2 cells against LPS-induced inflammatory and metabolic damage. Specifically, in these cells, we have …
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A Clonal, Transcriptomic, and Functional Analysis of T-cells Mobilized to Blood in Response to Acute Exercise
… between physical activity and the body’s defense system that has prompted the investigation of immune modulation via exercise. Over the last few decades, it has been established that both chronic and acute exercise act as an immune system adjuvant that improves defense mechanisms to reduce the …
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Computational analysis and method development for high throughput transcriptomics and transcriptional regulatory inference in plants
… used in functional genetics and transcriptomics, system biology and developmental biology in animals, plants, diseases, etc. The aim of this project is to use mathematical and computational models to integrate big genomic and transcriptomic data from high-throughput technologies in plant biology …
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Understanding grapevine responses to abscisic acid
Abscisic acid (ABA) regulates various developmental processes and stress responses over both short (i.e. hours or days) and longer (i.e. months or seasons) time frames. To elucidate the transcriptional regulatory the early responses of grapevine (Vitis vinifera) responding to ABA, different organs …
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On the application of numerical continuation to large-scale dynamical systems
The system approach in dealing with large groups of components with nonlinear interactions has received constantly growing attention in recent years in wide variety of applications from system biology to the size evolution of aerosol particles. These systems exhibit complex behaviors that are not …
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A systems biology approach to the pathogenesis and progression of Non-Alcoholic Fatty Liver Disease
… and defines new approaches to study NASH with system biology and translational approaches, exploiting novel methods that had never been used in NAFLD research.
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Transcriptomic analyses of Clostridium beijerinckii NCIMB 8052 during transition from acidogenesis to solventogenesis and under butyrate supplemented conditions
… C. beijerinckii strain improvement employing system biology-based strategies and metabolic engineering approaches. Furthermore, this work is also an essential methodology reference for conducting transcriptional analysis employing next-generation sequencing technology.
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Metabolic engineering of Saccharomyces cerevisiae for efficient ethanol production from pentose sugars
… strains. In addition to the gene expression systems, a scar-less gene modification method was also investigated in the industrial strains and promising preliminary results were obtained. By introducing a new pentose-specific transporter, optimization of the heterologous pentose utilization …
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