Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 217 for “"synuclein"”.
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Alpha Synuclein Oligomers in Human Pathology: Significance of Nitrative Alpha Synuclein Modifications
… aggregates of αSyn is a pathological hallmark of synucleinopathies such as Parkinson disease (PD) and dementia with Lewy bodies (DLB), which are clinically characterized by motor and cognitive dysfunction. Recent evidence indicates that αSyn oligomer intermediates are the most neurotoxic species. …
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Metabolism of Alpha-Synuclein by the 20S Proteasome
… aggregation of the neuronal protein alpha-synuclein (alphaSyn) that normally associates with synaptic vesicles. Within the aggregates, a fraction of alphaSyn is truncated at the C-termini, and these truncations are hypothesized to participate in disease pathogenesis. The prevailing model …
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Aggregation of alpha-synuclein using single-molecule spectroscopy
The aggregation of alpha-synuclein (αS) protein from soluble monomer into solid amyloid fibrils in the brain is associated with a range of devastating neurodegenerative disorders such as Parkinson’s disease. Soluble oligomers formed during the aggregation process are highly neurotoxic and are …
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The functional and pathological pathways of α-Synuclein
… aggregation of intrinsically disordered α-Synuclein (αS) is associated with Parkinson’s disease (PD) and other neurodegenerative diseases termed synucleopathies, whereby αS aggregates are a major constituent of Lewy bodies, a hallmark of these diseases. Despite the apparent link between αS …
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α-Synuclein phosphorylation and related kinases in Parkinson’s disease
… pathologies largely made from insoluble α-synuclein phosphorylated at serine 129 (S129P). Several kinases have been suggested to facilitate α-synuclein phosphorylation in PD, but without significant human data the changes that precipitate such pathology remain conjecture. The major aims of …
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Effects of Aggregated Alpha-Synuclein on Cultured Neuronal Cells
<p>α-synuclein dysregulation is a critical aspect of Parkinson's disease pathology. Recent studies have observed that α-synuclein aggregates are cytotoxic to cells in culture and that this toxicity can be spread between cells. However, the molecular mechanisms governing this cytotoxicity and spread …
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Plasma alpha synuclein assay in Parkinson's disease and parkinsonisms
E' stato condotto uno studio osservazionale trasversale caso controllo finalizzato al dosaggio plasmatico della alfa sinucleina nella malattia di Parkinson e in soggetti sani di controllo. La alfa sinucleina decrementa nei maschi ma non nelle donne al progredire della malattia. Inoltre solo negli …
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Solid-state NMR studies of α-synuclein fibril structure
… disease (PD). Their primary protein component, α-synuclein (α- syn), adopts an amyloidogenic fibrillar form in Lewy bodies. In recent years research has slowly started to unravel clear pathological links between this fibrillar protein and PD disease progression. While great progress is being made, …
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Targeting and Localization of Alpha-Synuclein in Primary Neurons
… dysfunction and aberrant accumulation of alpha-synuclein (alpha-syn) has been linked to neurodegenerative conditions such as Parkinson's disease (PD) and dementia with Lewy bodies. Previous studies have shown that alpha-syn normally undergoes delayed localization to presynaptic terminals but the …
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The prion-like properties of assembled human alpha-synuclein
… inclusions in nerve cells and glial cells. Alpha-synuclein is the main component of the inclusions of Parkinson’s disease, dementia with Lewy bodies and multiple system atrophy, as well as of rarer diseases, collectively called synucleinopathies. For a long time, it was widely believed that …
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Investigating in vitro Alpha-Synuclein Aggregation of Parkinson's Disease
… component of Lewy pathology is aggregated α-synuclein (α-syn), particularly involving phosphorylated forms at Serine 129. In familial PD cases, mutations in the SNCA gene encoding α-syn are involved. Despite being recognised as a key neuropathological characteristic, the role of α-syn remains …
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Rational Design of Antibodies against Tau and Alpha-Synuclein
… such as amyloid beta (Abeta), tau, and alpha-synuclein (aSyn). Although these protein deposits correlate to some extend with disease progression and cognitive decline, increasing evidence suggests that small intermediate aggregate species called oligomers are the primary driver of cytotoxicity …
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Regional Lysosomal Malfunction Underlies the Selectivity of α-Synuclein Neurodegeneration
… pathway results in distinct pathologies. α-Synuclein is a protein whose aggregation and oligomerization has been implicated in several diseases, including Parkinson’s disease (PD). Herein, we investigated regionally selective alterations in α-synuclein degradation to decipher potential …
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Methionine Sulfoxide Reductase and Ubiquitin-dependent Degradation of Alpha-synuclein
Alpha-synuclein (αSyn) is one of the key proteins considered to be involved in the pathogenesis of the Parkinson`s disease (PD) and being the main component of Lewy bodies (LBs). Studies on the αSyn gene mutants and overexpression of αSyn in yeast and rodent brains indicate that the level of αSyn …
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Solid-State Nuclear Magnetic Resonance Spectroscopy of Alpha-Synuclein Fibrils
… solving 3D structures of amyloid fibrils. Alpha-synuclein is a 140-residue protein that has been implicated in Parkinson's disease. Fibrils of alpha-synuclein are the primary fibrillar component of Lewy bodies, which are the pathological hallmark of the disease; however, the role that synuclein …
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Structural Properties of α-Synuclein in Functional and Pathological Contexts
α-synuclein (αS) is an intrinsically disordered protein that is strongly connected with Parkinson’s disease (PD) and a number of other neurodegenerative disorders, including Parkinson’s disease with dementia, dementia with Lewy bodies and multiple system amyotrophy. Fibrillar aggregates of αS have …
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Modeling intrinsically disordered proteins ; a comprehensive study of [alpha]-synuclein
… substantia nigra. Several studies suggest that a-synuclein, the major component of these intracellular inclusions, plays a major role in the neurodegenerative process. Therefore understanding the structural properties of [alpha]-synuclein and its aggregation mechanism is of particular interest. …
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Development of single-molecules techniques to study native α-Synuclein aggregates
It is now widely recognised that α-Synuclein (αSyn) oligomers are the main pathogenic species in Parkinson’s Disease (PD). In addition to being cytotoxic they are also thought to play a central role in the interneuronal spread of αSyn pathology. There is compelling evidence to suggest that these …
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Oxysterols in Neurodegeneration and the Influence of Presynaptic α-Synuclein Phosphorylation
… dysfunction, with a specific focus on alpha-synuclein (aSyn), a presynaptic protein centrally involved in PD pathology. Biophysical analyses revealed that both 24S-HC and 27-HC bind directly to aSyn with higher affinity than cholesterol. Interestingly, despite this binding, 27-HC does not …
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