Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 113 for “"synthetic studies"”.
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Synthetic studies of luzopeptins
Luzopeptins are a series of cyclic depsipeptides which possesses potent antitumor and antiviral activities. There is no total synthesis of Luzopeptins has been achieved. In our own effort to synthesize the luzopeptins, we developed a concise and practical route to PCA, 86, and an efficient protocol …
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Synthetic Studies Towards Mescengricin
This thesis describes the synthetic efforts towards mescengricin (80), an ɑ-carboline alkaloid isolated from a culture of Streptomyces griseoflavus. Mescengricin (80) may be a prominent neuroprotectant for ischemic injury as it protected chick primary mesencephalic neurons from L-glutamate toxicity …
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Synthetic studies utilizing podocarpic acid
The ketoester, 3-ethoxycarbonyl-12-methoxy-5βH-18,19-bisnor-podocarpa-8,11,13-trien-4-one(80). The numbering used throughout this thesis is that proposed by J.W. Rowe (personal communication to Dr. R. C. Cambie) in 'The Common and Systematic Nomenclature of Cyclic Diterpenes', 3rd Revision, Oct. …
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Synthetic studies towards multichromophore arrays
The overall aim of this project was to investigate strategies for linking macrocyclic chromophores to form arrays. Firstly the aim was to link a porphyrin to a triphenylene through phenyl alkynes. Interestingly, this study discovered a mesogenic dibromtetramethoxy triphenylene – the least heavily …
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Synthetic Studies Towards the Crisamicins
This thesis describes synthetic work directed towards the synthesis of the dimeric pyranonaphthoquinone antibiotic crisamicin A 1.46 and its regioisomer 2.77. The synthetic strategy adopted is based on a double furofuran annulation/oxidative rearrangement strategy that has been successfully used by …
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Synthetic studies related to penicillin
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1952.
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Synthetic Studies of the Yunnaneic Acids
… sequence from simple precursors. Dimerization studies towards yunnaneic acid A and yunnaneic acid B are also described, which resulted in the synthesis of several novel, non-natural structures.
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Synthetic Studies in the Didemnin Series
Semi-synthetic studies directed toward didemnin analogues in which structural modifications were introduced in the side chain for investigating structure-activity relationships have been performed. The syntheses of several known didemnins including didemnin M, dehydrodidemnin B, and pyroglutamyl …
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Synthetic studies towards an organometallic rotaxane
The synthesis of interlocking molecules such as rotaxanes and catenanes is a branch of supramolecular chemistry of particular current interest. The aim of this work was to assess the viability of the synthesis of an organometallic rotaxane in which the transition metal is covalently bonded to a …
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Synthetic studies on Canangone and beta-Chamigrene
The objective of this work was to synthesize the quaternary stereocenter containing spirocycles, (+)-Canangone and beta-Chamigrene. Michael acceptor was prepared in three steps. The Robinson annulation of enamino lactone and Michael acceptor followed by hydrolysis provided the spirolactone. …
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Spectroscopic and synthetic studies of lichen metabolites
… been subjected to a number of spectroscopic and synthetic investigations. Hypoiodite reaction of 15α-acetoxyhopan-17(21)-en-24-ol yielded a complex mixture of products, while similar reaction of 7-oxohopan-22-ol resulted in cleavage of the side-chain. Preparation of an α-sulphenylated 15-ketone …
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Synthetic Studies of the Rubellin Natural Products
… relevant recent natural product syntheses, our studies on the rubellin class of natural products, and our investigation of a rearrangement reaction of reactive iodonium ylide intermediates. First described are select syntheses of complex anthraquinone monomers and dimers within the past 20 …
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Synthetic studies towards total synthesis of bielschowskysin
This thesis presents the synthetic studies towards the natural product bielschowskysin. Bielschowskysin, a new diterpene isolated from the Caribbean gorgonian octocoral Pseudopterogorgia kallos, possesses a fascinating tricyclic [5-4-9] ring architecture, unprecedented in the realms of natural …
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Synthetic studies of ecteinascidin 743 and fennebricin B
… product. This approach was also utilized in the synthetic studies toward the total synthesis of fennebricin B.
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Epidithiodioxopiperazines: synthetic studies of (+)-chetomin and (-)-sporidesmin A
… products (+)-chetomin and (-)-sporidesmin A. Synthetic methods have been developed to efficiently construct the dioxopiperazine core of both molecules. Additionally, a simple epidithiodioxopiperazine has been synthesized to demonstrate a general method for the addition of a sulfur bridge to a …
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Mechanistic and Synthetic Studies of Oxidopyrylium Cycloaddition Reactions
… mechanistic considerations as well as the unique synthetic advancements of their corresponding cycloadducts. Chapter 1 is a literature review where we specifically outline the use of oxidopyrylium cycloadditions in the synthesis of natural products. This includes the mention of previous syntheses …
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Synthetic Studies towards Opaliferin, a Tetracyclic Polyketide Metabolite
… THF structural motif. Our initial retrosynthetic strategy was devised around the acid-catalysed spirocyclisation of advanced intermediate 201, which was anticipated to be assembled via modular synthetic strategy. With this strategy, compounds 204 and 274 were identified as key …
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