Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"synthetic retinoid"”.
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Surface Functionalised Emulsion- Templated Porous Polymers for In- Vitro Cell Culture
… attachment to the surface of the PolyHIPE with synthetic retinoid EC23 has been proposed, and initial chemical tests obtained to suggest attachment, with future testing with mammalian cells envisaged.
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Evaluating The Therapeutic Efficacy of Restoring Wild-Type P53 Activity In P53-Mutant Tumors
… that pharmacological activation of RARγ with the synthetic retinoid, CD437, sensitizes resistant tumors to p53 restoration while additively improving outcome and survival in tumors inherently sensitive to p53 restoration.</p>
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Mechanism(s) involved in the transport of Fenretinide across Caco-2 monolayers
<p>Femetinide is a synthetic retinoid with chemotherapeutic activity against various malignancies. After oral administration to animals, femetinide was found to be incompletely absorbed and excreted primarily in feces. The purpose of this study was to investigate the mechanism(s) responsible for …
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Combination Therapy For the Treatment of Human Malignant Neuroblastoma
… neuroblastoma cells, where a combination of the synthetic retinoid N-(4-hydroxyphenyl) retinamide (4-HPR) and the flavonoid apigenin (APG) suppressed starvation-induced autophagy and triggered apoptosis. In our final combination strategy, we induced cellular differentiation in immature …
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Synthesis and Characterization of Bexarotene Derivatives with Potential Biological Activity // Получаване и охарактеризиране на бексаротенови производни с потенциална биологична активност
… of the newly synthesized derivatives of the synthetic retinoid bexarotene. The continued and intensive study of the role of retinoids in the complex of differentiation, cell proliferation, and cellular growth processes determines the major potential for the using of retinoids (natural and …
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Investigating the role of CYP26 and retinoic acid signaling regulation in vertebrate cornea and lens regeneration
… greatly inhibited lens regeneration. Likewise, a synthetic retinoid that activates RA signaling without being metabolized by CYP26 also inhibited regeneration, as did excess exogenous RA. In all treatments, we observed profound upregulation of the RA signaling marker cyp26a1. Taken together, we …