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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"synthetic polypeptides"”.
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Development and study of synthetic polypeptides for biomaterial applications
… cell substrates. Attempts at using the clickable synthetic polypeptide poly(ypropargyl L-glutamate) (PPLG) to form a self-assembly amphiphilic system is discussed, as is the formation of potentially amphiphilic block copolymers with PPLG. The synthesis of a hydrolytically stable synthetic …
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Amino acid N-carboxyanhydrides and polypeptides: Controlled polymerization, properties and applications
… of α-amino acid N-carboxyanhydrides (NCAs) and synthetic polypeptides based materials. Polypeptides are a class of emerging biomaterials receiving increasing interests for various applications including drug delivery, gene therapy, antimicrobial and tissue engineering. The ring-opening …
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Synthetic polypeptide-based hydrogel systems for biomaterials
Hydrogels formed from synthetic polypeptides generated by ring opening polymerization (ROP) of a-amino acid N-carboxyanhydrides (NCAs) present a robust material for modeling the interaction between extracellular matrix (ECM) properties and cellular phenomena. The unique properties of the …
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Site-Specific Incorporation of Biochemical and Biophysical Probes into Proteins Using Expressed Protein Ligation
… recombinantly but also altered covalently using synthetic chemistry. These two methods are brought together in the protein semi-synthesis technique Expressed Protein Ligation (EPL). In EPL, recombinant and synthetic polypeptides are joined together via a chemoselective ligation reaction. EPL was …
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Understanding barriers to efficient nucleic acid delivery with bioresponsive block copolymers
… by immunogenicity and toxicity concerns, but synthetic vectors have lagged in transfection efficiency. This thesis describes the rational design and systematic study of three classes of bioresponsive polymers for nucleic acid delivery. A central theme of the study was understanding how the …
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Step-growth hydrogels crosslinked through grafted polypeptides enable nano- to macroscale synthetic extracellular matrix design
Step-growth hydrogels crosslinked through grafted polypeptides are introduced as a powerful platform for extending the potential of established hydrogel systems, especially for applications in tissue engineering. Gels crosslinked through grafted polypeptides offer the potential to address many …
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The α-helical conformation of polypeptides: design, regulation, and applications
Synthetic polypeptides have received increasing attention during the past two decades. Compared to other synthetic polymers, polypeptides share the same peptide backbones with naturally-occurring proteins, which allows them to form higher order structures spontaneously and enables their unique …
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Synthesis and testing of novel polypeptides for biological applications
… of polymer chemistry is the ability to generate synthetic systems that can demonstrate the highly ordered structure, self-assembly, and responsive behavior of these macromolecules. Synthetic polypeptides have received attention because of their unique structural properties and biocompatibility. …
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Spektroskopische Strukturanalytik synthetischer Polypeptide
In der vorliegenden Arbeit wurden zwei spektroskopische Methoden (Raman- und Circulardichroismus-Spektroskopie) und die Kernspinresonanz zur Untersuchung der Sekundärstruktur von synthetischen Polypeptiden eingesetzt. Dabei wurden die Struktur-Funktions-Beziehungen der dritten extrazellulären …