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Showing 1 to 20 of 56 for “"synthetic methodologies"”.
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Development of new synthetic methodologies
Several new synthetic methodologies of chemically and biologically importance are described in this dissertation. These include electrophilic aminohalogenation, electrophilic diamination, Baylis-Hillman type bond formations and Mukaiyama aldol type reactions. These reactions are for either …
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EXPLORING NOVEL SUSTAINABLE SYNTHETIC METHODOLOGIES WITH NITRO COMPOUNDS
The present thesis work is devoted to the study of four different topics, the reduction of nitroolefins employing ammonia borane as reductant, the enantioselective reduction of β,β-disubstituted nitroalkenes in deep eutectic solvents, the preliminary investigation of other enantioselective …
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DEVELOPMENT OF PRECIOUS METAL-FREE, LIGHT-ENABLED SYNTHETIC METHODOLOGIES
… development of more sustainable and eco-friendly methodologies in the field of organic synthesis. The use of light is particularly attractive not only because light is a traceless and abundant form of energy, but also because the absorption of photons can undisclose several reaction pathways which …
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Synthetic methodologies toward the functionalization of benzhydrols and carbohydrates
… groups onto complex substrates. Herein, synthetic methodologies were developed for the direct azidation of benzhydryl alcohols and carbohydrates to afford diarylazidomethane analogues and glycosyl azides. In this work, reaction conditions were optimised to afford the targeted azide …
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Development of synthetic methodologies for polyolefin containing block copolymers
The student, Tianwei Yan, submitted this Dissertation for approval on 2021-03-29 at 19:56.
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DEVELOPMENT OF SYNTHETIC METHODOLOGIES TOWARDS CYCLIC HYDROXAMIC ACID-BASED NATURAL PRODUCTS
… Our research targets to develop new synthetic methodology towards making cyclic hydroxamic acids in a stereoselective and regioselective fashion. Basic decomposition of Piloty's acid transforms cyclic ketones (mainly four and five membered) into ring-expanded cyclic hydroxamic acids …
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New Synthetic Methodologies for the Construction and Optimization of Natural Products
Toxicity associated with bioactive natural products is considered as a major obstacle in the process of drug discovery. Manzamine A (MA) is one such candidate that requires optimization to overcome the toxicity problem. The manzamine alkaloids represents a unique class of natural products that have …
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New synthetic methodologies utilizing reductive cyclizations catalyzed or mediated by titanocene complexes
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1997.
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BORAHETEROHELICENES: SYNTHETIC METHODOLOGIES AND PROPERTIES OF A NOVEL CLASS OF BORON Π-CONJUGATED SYSTEMS
… could be accessible via currently unexplored synthetic routes. The design, synthesis, and properties investigation of new boraheterohelicenes (BHHs) is therefore a relevant research topic and is the object of this PhD project, aimed to obtain several BHHs with structural diversity, as well as …
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SYNTHETIC AND MECHANISTIC PHOTOCHEMISTRY OF ALKOXY ANTHRAQUINONES: POTENTIAL UTILITY IN DRUG DELIVERY AND SYNTHETIC METHODOLOGIES
This project delves into the mechanistic details of the photochemical reactions of alkoxy-anthraquinones in various media in order to devise potential applications of these photoreactions. Currently, Photodynamic therapy relies on the generation of singlet oxygen in cells which is not efficient …
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“Green” synthetic methodologies for the fabrication of gold nanostructures with photothermal properties for multi-responsive therapies [Metodologie sintetiche “ Verdi” per la fabbricazione di nanostrutture d'oro con proprietà fototermiche per terapie multi-reattive]
Il basso tasso di ricambio dei nuovi farmaci, unito alla resistenza multipla dei farmaci da parte delle cellule tumorali e dei batteri, rende necessaria la ricerca di nuovi approcci terapeutici. Le terapie fototermiche (PTT) e fotodinamiche (PDT), basate sul rilascio foto-controllato di calore e …
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Synthetic methods for biologically relevant organofluorine compounds
"This thesis describes novel synthetic methodologies for the synthesis of biologically relevant organofluorine compounds"--Abstract, page iii.
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The design, synthesis and mesomorphic properties of discotic liquid crystals
… down into three major areas: investigation of synthetic methodologies of hexasubstituted triphenylene-based discotic liquid crystals, examination of structure-property relationships within novel triphenylene-based discotic liquid crystalline materials, and the design and mesomorphic properties …
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The evolution of organic synthesis in the solid-state approach: from grinding to mixing
… to mixing’ focuses on the development of synthetic methodologies by addressing the problem of both sustainability and performance of these procedures. This problem represents a significant challenge, as the environmental impact of current protocols is too high to continue to be used as …
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Novel metal- and main group-catalyzed methods for modulating molecular oxygenation
Synthetic methodologies frequently rely on oxygen functionality as a synthetic handle to enable structural modification of organic molecules; therefore, methods that enable new ways to modulate oxygen content in molecular structure facilitate structural diversification. This thesis details the …
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Synthesis and biological evaluation of functionalized benzoxaboroles as potential antimicrobial agents
… chemistry, and also as cross-coupling agents in synthetic chemistry. Boronic acids often function as inhibitors for various enzymes due to their unique electronic and physicochemical properties. B-hydroxy-1,2-oxaborolanes (benzoboroxoles) are a class of cyclic boronic acid derivatives and are …
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Synthesis and Reactivity of Anthracene-Based Molecular Precursors for Low-Valent Boron Species
… However, due in large part to a lack of suitable synthetic methodologies, the chemistry of numerous desirable functionalities remains poorly accessible. Herein, we report the synthesis of the first series of dibenzo-7-boranorbornadienes, or 9,10-bridged boron anthracene (RBA, A = anthracene or …
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CONTINUOUS-FLOW STRATEGIES FOR THE PREPARATION OF ACTIVE PHARMACEUTICAL INGREDIENTS AND RELEVANT INTERMEDIATES
… The work focuses on the integration of modern synthetic methodologies with enabling technologies such as flow chemistry, photoredox catalysis, ultrasound, and electrochemistry. In the first part, palladium-catalyzed cross-coupling reactions involving highly reactive organolithium reagents are …
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Synthetic and Computational Studies on Polycyclic Aromatic Hydrocarbon Derivatives, Nucleoside Analogs and Peptides
… hydrocarbons (PAHs) and β-peptides are among synthetic organic compounds known to interact with natural biological macromolecules. This interaction may affect the specific biological functions of the biomacromolecules. A variety of synthetic methodologies have been employed in the synthesis of …
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Síntese de novos adutos de Morita-Baylis-Hillman com potencial atividade biológica.
… biological activity. Was developed in this work, synthetic methodologies for the preparation of 16 AMBH unprecedented (47-62), getting good and high yields and moderate reaction times. Initially was synthesized AMBH 8 using the 2-hydroxyethyl Acrylate 45 as Michael acceptor, giving the adducts 47 …
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