Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"synthetic estrogen"”.
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Comparative Immunological Effects of a Natural Estrogen (17β-estradiol) versus a Pharmacologic Synthetic Estrogen (17α-ethinyl estradiol)
Exposure to exogenous estrogens such as synthetic 17α-ethinyl estradiol (EE) occurs via multiple sources (i.e. hormonal contraceptives, environmental contamination, hormone replacement therapy). The natural estrogen, 17β-estradiol (E2), is a well-studied immunomodulatory hormone at both …
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Appearance Over Function - The Impact of Long-Term Oral Contraceptive Use on Brain Development, Breast Tissue Composition, and Future Lactation Outcomes
… and reproductive systems. The introduction of synthetic estrogen and progestin through COC use during this time may disrupt natural hormonal pathways, potentially altering neuroendocrine signaling and breast tissue maturation. Such changes may have lasting consequences, including impaired milk …
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I. Design and synthesis of estrogen receptor gene switches. II. Design and synthesis of estrogen receptor ligands occupying an auxiliary binding pocket
The estrogen receptor (ER) is ligand-regulated nuclear hormone receptor and an important therapeutic target for breast cancer, hormone replacement therapy, contraception, and osteoporosis. Novel organic cores have been identified and developed as possible estrogen pharmaceuticals. The x-ray …
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The effects of diethylstilbestrol on myometrial contractility in mice
<p>"Diethylstilbestrol (DES) is a synthetic estrogen used in the United States from 1938-1971 for the prevention of preterm birth. It has been shown to cause structural changes to the myometrium of mice and humans, as well as gross anatomical malformations, adenocarcinoma, and infertility in both …
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Effects of Diethylstilbestrol on Murine Early Embryonic Stem Cell Differentiation Using an Embryoid Body Culture System
Objectives: The effects of estrogens on immune system formation and function are well documented. Diethylstilbestrol (DES), a synthetic estrogen, has been linked to neoplasia and immune cell dysfunction in humans and animals exposed in-utero. In-vitro effects of DES exposure of murine embryonic …
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Organ and primary culture of medaka (Oryzias latipes) testis: Test systems for the analysis of cell proliferation and differentiation
… systems were used to analyze the effects of a synthetic estrogen, EE2, on cell proliferation in medaka testis. Both organ and primary culture were suitable for this purpose consistently small concentrations (0.01 and 1 nM) of EE2 stimulated cell proliferation slightly, while higher …
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The nongenomic effects of physiological and environmental estrogens on dopamine transporter function
… nongenomic effects of several physiological estrogens [estradiol (E2) estrone (E1), and estriol (E3)] and xenoestrogens (XEs), such as organochlorine pesticides [dieldrin, endosulfan, and o¡¯,p¡¯-dichlorodiphenylethylene (DDE)], plastics manufacturing by-products/detergents (nonylphenol, …
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The mechanism of T cell dysfunction induced by Diethylstilbestrol
Estrogens have the ability to alter the immune system. Diethylstilbestrol (DES), asynthetic estrogen, is known to have estrogenic activity and induce thymic alterations.We investigated the mechanism by which DES is able to alter T cells and thus theimmune system. First, we studied the effect of DES …