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Showing 1 to 1 of 1 for “"synthetic essentiality"”.
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Synthetic Essentiality of Tdo2 In Apc-Mutated Colorectal Cancer
… <p>CRC and other cancers. Using the concept of synthetic essentiality (SE), we</p> <p>sought to identify essential effectors of APC deficiency with the goal of</p> <p>expanding targetable vulnerabilities in CRC. We identified Tryptophan 2,3-</p> <p>dioxygenase 2 (TDO2) as an SE gene for …