Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 25 for “"synthetic analogues"”.
-
Synthetic analogues of protein-lipid complexes
… (DLPC) produces polymer-lipid complex analogues to lipoprotein assemblies found in lung surfactant. These complexes represent a new bio-mimetic delivery vehicle with applications in the cosmetic and pharmaceutical industries. The primary aim of this study was to develop a better …
-
Binding and transport of calcium by synthetic analogues of ionomycin
The syntheses of simple analogues of ionomycin (3), namely a series of f3-diketoco-carboxylic acids 4-6, 28-30 and 33-35, were achieved by consecutive alkylation of the dianion of 2,4-pentanedione (7) with appropriate bromides and subsequent oxidation of theP-diketo tau-alcohols. The transport of …
-
Structural phase transitions in synthetic analogues of the titanite structure type
… in transition metal oxides. Towards this aim, synthetic derivatives of the mineral titanite, CaTiOSiO4, are used as model compounds. The study is focusing on the occurrence of displacive phase transitions in compounds with the 2:4:4 cation charge combination: SrTiOGeO4, CaTiOGeO4, CaZrOGeO4 and …
-
Design of Nanostructured Peptoid Assemblies as Synthetic Analogues of Natural Carbonic Anhydrases
In recent years, the rising carbon dioxide concentration worldwide has become a significant focus of scientific research. Carbon capture represents a feasible solution to the reduction of atmospheric CO2 and carbonic anhydrase functions as a natural carbon dioxide hydrase to hydrate carbon dioxide …
-
Synthetic Analogues of Dinitrosyl Iron Complexes: Reactivity Studies and Improvements towards Therapeutic Applications
… has led to biomimetic work on such entities in synthetic inorganic chemistry. Recently, such synthetic models have emerged as a new class of potential NO releasing agents. A series of N-heterocyclic carbene (NHC)-stabilized oxidized and reduced DNICs ({Fe(NO)2}^9 /{Fe(NO)2}^10: Enemark-Feltham …
-
(I) Zinc complexes as synthetic analogues for carbonic anhydrase and as catalysts for H₂ production and CO₂ functionalization . . .
… carbonyl precursor provides a novel, convenient synthetic method that circumvents the use of the free isocyanide as a reagent. Metal isocyanide compounds are most commonly synthesized using the free isocyanide. By contrast, the reaction of transition metal carbonyl compounds, LnMCO, with …
-
Optimalios sarpaginų šeimos alkaloidų sintezės paieška /
… routes to the relevant oxygenated tryptophan analogues.By contrast, the potential of the 9-azabicyclo[3.3.1]nonane synthons for de novo construction of the indole moiety of cycloocta[b]indole core is considerably less explored. In this work, a generalized synthetic access to Sarpagine …
-
Structural studies of organic crystals of pharmaceutical relevance. Correlation of crystal structure analysis with recognised non-bonded structural motifs in the organic solid state
… systems as well as exploiting those using synthetic analogues. A total of 51 crystal structures were investigated including 16 new structure determinations. Addition synthesis of new xanthines to investigate novel intermolecular patterns was also undertaken. The understanding and …
-
Using Data-Driven Models to Understand Transition Metal Catalyst Energy Landscapes and Metal-Organic Framework Stability
… unearthing design rules for scalable and viable synthetic analogues that preserve selectivity and activity observed only in enzymes. Single-site catalysts represent the most promising synthetic analogues to these enzymes, often enabling atom-economy, tunability, and selectivity not possible with …
-
Oxygen Atom Transfer Reactions Catalyzed by Molybdenum and Tungsten Oxo Transferase Mimics
… to mimic enzymatic oxidation reactions with synthetic catalysts is essential for advancing selective and sustainable chemical transformations. Nature employs molybdenum and tungsten enzymes to mediate oxygen atom transfer (OAT) reactions, which are critical in biological redox processes. …
-
Total Synthesis of Clavatadine A Analogs to Produce a Viable Reversible Inhibitor for Factor XIa
… and biological testing of clavatadine A and synthetic clavatadine A analogues that selectively inhibit factor XIa would represent a new direction in cardiovascular disease research. A potent and selective factor XIa inhibitor has the potential to be a safer replacement for current …
-
s-Triazine-Based Self-Assembling Information Molecules
… assembly and template-directed synthesis, i.e. synthetic analogues of DNA. The oligomers are composed of four components: a recognition-based pairing system, backbone, linker and solubility controlling moieties. The oligomers were synthesised using the selective reactivity of trichlorotriazine. …
-
Characterisation of the immunomodulatory properties of human natural killer T cells
… human peripheral blood. iNKT stimulated with synthetic analogues of αGalCer have shown the potential as tailored adjuvants for dendritic cell (DC) based immunotherapy. We established a system to test the immunostimulatory ability of iNKT cell analogues on DC maturation and function. A novel …
-
Protein- hormone interactions patterning the gynoecium
… and exhibits specificity for IAA over the synthetic analogues NAA and 2,4-D. This coreceptor functions to coordinate the development of the style and stigmatic tissues of the carpel, possibly via the regulation of PID kinase. Further, this work has also identified novel roles in …
-
Mechanisms of cytokinin action
1. Twenty-two synthetic analogues of adenine were tested for their ability to promote the growth of Chinese cabbage leaf discs. In general an adenine residue substituted in the N6 position with a group of moderate size is required for maximum growth activity. 2. Kinetin increases the turnover of …
-
Method Development And Applications To Screening And Characterization Of Rrna-Targeting Small Molecules
<p>A series of single ring aminoglycoside analogues was tested for binding to a model RNA representing the A site using electrospray ionization mass spectrometry (ESI-MS). Several of the synthetic analogues with low molecular weights were found to bind to the RNA with affinities comparable to the …
-
Hemmung der Eisrekristallisation in wässrigen Lösungen durch Antigefrierglykopeptide
… determination of the efficiency of AFGP and some synthetic analogues in inhibiting recrystallization. The effects of very small structural changes became evident, allowing for the establishment of quantitative structure-activity relationships, in contrast to previous qualitative studies. The most …
-
Synthesis and Biological Investigation into the Metabolism of Retinoids
… cause of many unwanted problems / side effects. Synthetic retinoids have been made by replacing key functional groups with more robust pharmacophores which retain the key functionalities of natural retinoids but are resistant to isomerisation. Previous studies have shown that synthetic retinoids, …
-
HIGH-PRESSURE BEHAVIOUR AND CRYSTAL-FLUID INTERACTION OF THE ABC-6 ZEOLITES: THE CASE OF ERIONITE, OFFRETITE AND BELLBERGITE
… few kbar to GPa) of zeolites, both natural and synthetics, particularly concerning the crystal-fluid interactions mediated by pressure. Given the zeolites capacity to host and exchange H2O, other small molecules or monoatomic species (e.g., nobles gases), experiments involving hydrostatically …
Page 1 of 2