Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 103 for “"syngeneic"”.
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Myxoma Virus Therapy of Malignant Gliomas in Murine Syngeneic Models: Translating Barriers to Therapy
… overwhelming treatment responses. Interestingly, syngeneic glioma models have shown results more typical of what was seen in the clinic. This study was undertaken to identify the potential immune-effectors mediating Myxoma virus (MYXV) clearance in immunocompetent mouse models. MYXV is a …
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Chimeric Thrombomodulin and CD47 proteins synergistically improve the engraftment of islets by mitigating IBMIR
… inflammatory response (IBMIR). In chapter 3, syngeneic pancreatic islets are engineered with a novel form of TM (SA-TM) to maintain euglycemia by preventing the immediate loss of islet transplant grafts. In chapter 4, the pancreatic islet was engineered with SA-TM and CD47 combination to …
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Characterizing the Impact of Specific Genetic Mutations on Chemotherapy Resistance and the Efficacy of Oncolytic Viruses for the Treatment of Ovarian Cancer
… VSV∆M51 replication in-vitro and sensitivity in syngeneic in-vivo models. VSV∆M51 prolonged survival in syngeneic tumour- bearing mice with KRas, Trp53 and Pten mutations, including one tumour model that did not respond to carboplatin. Response to VSV∆M51 in-vivo was associated with activation of …
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AXL Targeting Restores PD-1 Blockade Sensitivity of STK11/LKB1 Mutant NSCLC Through Expansion of TCF1+ CD8 T Cells
… and Trp53 (KP) resulted in an ICB refractory syngeneic KPL tumor. Mechanistically, this occurred because KPL mutant NSCLCs lacked TCF1-expressing CD8 T cells, a phenotype that was recapitulated in human STK11/LKB1 mutant NSCLCs. We found that systemic inhibition of Axl results in increased …
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Loss of Caspase-8 Function In Combination With Smac Mimetic Treatment Sensitizes Head and Neck Squamous Carcinoma to Radiation Through Induction of Necroptosis.
… necroptosis in HSNCC using cell line models and syngeneic mouse xenografts. <em>In vitro</em>, knockdown of CASP8 rendered HNSCCs susceptible to necroptosis induced by a second mitochondria-derived activator of caspase (SMAC) mimetic, Birinapant, when combined with pan-caspase inhibitors zVAD-FMK …
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Age-associated alterations in the immune system of normal and autoimmune-susceptible mice
… study the age-induced differential responses of syngeneic T cells and B cells. These cell interactions were found to be greatly diminished in old DBA/2 mice, and this appeared to be due to an intrinsic defect in the cells from old mice. A decreased syngeneic mixed lymphocyte reaction (SMLR) was …
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Dissecting cell-autonomous and microenvironmental factors governing lymphatic metastasis in breast cancer
… lymph node involvement. Using transplantable syngeneic mammary carcinoma 4T1 model, a differential preference for using the lymphatic system as a dissemination route was observed in immunocompetent mice when compared to immunodeficient mice. Characterisation of the differences in the tumour …
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Role of Properdin in Tumour Growth and Cell Recruitment
… project investigated the role of properdin in a syngeneic orthotopic tumour<br/>model in mice engineered to be properdin deficient and their wildtype controls.<br/>The in vitro part of the project used macrophages differentiated from bone<br/>marrows of these mice and stimulated with conditioned …
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Cxcr2 Expression In Tumor Cells Is A Poor Prognostic Factor and Promotes Invasion and Metastasis In Lung Adenocarcinoma
… with high metastatic potential and an orthotopic syngeneic mouse model and <em>in vitro </em>using a CXCR2 small molecule antagonist (SB225002). We showed that <em>in vivo</em> CXCR2 inhibition by knock-down reduces its invasive ability. In a murine model of orthotopic syngeneic lung …
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Development and Characterization of B7-H3-Targeted Radioimmunotherapies For The Treatment of Solid Tumors
… imaging demonstrated high retention in multiple syngeneic tumor models transfected with human B7-H3 compared to vector controls or tumors imaged with isotype control antibody (<sup>89</sup>Zr-DFO-IgG2a) and in immunodeficient tumor models with high B7-H3 tumor expression compared to B7-H3 KO …
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Engineering Tumor-Localized Therapies for Cancer – from Antioxidant Enzymes to Cytokines and Radiation Therapy
… and in vivo validation of our approaches in syngeneic mouse tumor models but failed to show therapeutic efficacy or transcriptional profiles consistent with the expected activity. Cytokines can be potent immunotherapies, inducing activation and proliferation of immune cells critical to …
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BREAST CANCER PROGRESSION AND METASTASIS: DISCOVERY OF NOVEL GENES AND THEIR FUNCTIONAL STUDY
… we performed gene expression analysis of syngeneic cell lines MCF10A, DCIS.com and MCF10CA and cross-referenced the targets using patient cohorts. By comparing gene expression between MCF10A and DCIS.com cell line, we identified ID2 as a regulator of DCIS initiation. ID2 promoted DCIS …
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Regulation of Myeloid Leukemia Cells by Platelet Factor 4
… alter the course of AML disease progression in syngeneic mouse models and human AML cells. We found that PF4 preferentially acts on LSCs via low-density lipoprotein receptor (LDLR) to inhibit their proliferation and deregulate lipid metabolism. When given in combination with chemotherapy, PF4 …
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Novel approaches and pharmacological considerations in melanoma treatment
… and -resistant melanoma cells lines. In vivo, syngeneic studies with DBF, compared tumour growth with free- and NP-bound drug: mice were treated with DBF daily via oral gavage (31.5 mg/kg) or NP-bound DBF twice weekly via intravenous injection (2.5 mg/kg). Both treatments significantly reduced …
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Metabolic Factors Determining Outcome in Chemotherapy: Studies with Pazopanib
… at variations in the efficacy of pazopanib in syngeneic tumours in humanised and wild-type mice.The techniques used in this work include liver microsome preparations and drug <br/>stability assays in vitro, pharmacokinetic profiling of drugs, and syngeneic tumour <br/>growth studies in vivo. …
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Generation and Transcriptomic Analysis of HIF-1Alpha and HIF-2Alpha Knockout 5TGM1 Multiple Myeloma Cells
… in the 5TGM1 mouse MM cell lines, which are syngeneic with the C57BL/KaLwRij mouse model. In this thesis, HIF-1α and HIF-2α inducible knockout and knocked-out 5TGM1 cells were generated using a doxycycline-inducible CRISPR/Cas9 system. Subsequently, HIF-1α and HIF-2α knockout 5TGM1 cells were …
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Splenic Regulation Of Cell Mediated Immunity To Listeria Monocytogenes: Suppression Of Macrophages
… mice were reconstituted with normal syngeneic spleen cells and normal plasma from Listeria-stimulated normal donors. Mice receiving spleen cells showed no decreased resistance by mice receiving plasma showed decreased resistance as determined from bacterial numbers in the liver. The …
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Imaging Biomarkers of Response to Immune Checkpoint Inhibition in Melanoma
… study on metastatic melanoma patients and syngeneic mouse models of cancer immunotherapy.
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Investigating the potential of the Metastasis Associated Antigen 1 (MTA1) for cancer immunotherapy in a murine model
… peptides from murine and human MTA1 gene for syngeneic and transgenic mice respectively.
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Effect of platinum chemotherapy on tumour infiltrating immune cells in metastatic ovarian cancer: Mechanistic insights and therapeutic applications
… Natural Killer (NK) cells contribute. Using two syngeneic models (UPK10 and ID8p53<sup>-/-</sup>) of metastatic ovarian cancer this thesis found that treatment with carboplatin upregulates NK cell activating receptor ligands, induced a pro-inflammatory phenotype and sensitised tumour cells to NK …
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