Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"syndecan-1"”.
-
The Syndecan-1 Paradox in HSV-1 Infection and Pathogenesis
… and the resolution of inflammatory responses. Syndecan-1 (SDC1), a major heparan sulfate chain-bearing proteoglycan, traditionally characterized as a primary attachment receptor that facilitates HSV-1 binding and entry through its heparan sulfate chains. However, its broader functional …
-
A Novel Syndecan-1 Targeted Therapeutic Antibody Inhibits Macropinocytosis and Induces Anti-Tumor Immunity in Pancreatic Cancer
… for this disease. Our previous work identified Syndecan-1 (SDC1), a highly expressed heparan sulfate proteoglycan, as a critical downstream effector protein of KRAS*, which promotes cancer progression by mediating macropinocytosis. Moreover, SDC1 plays an essential role for the acquired …
-
The Expression of Syndecan-1 is Related to the Risk of Endometrial Hyperplasia Progressing to Endometrial Carcinoma
… expression of the cell surface proteoglycan, syndecan-1, is found in many malignancies. The current study describes the immunohistochemical study of syndecan-1 expression in normal, hyperplastic, and malignant endometrial tissues for evaluation of application as a parameter of cancer …
-
The role of the arterial glycocalyx in sphingosine-1- phosphate induced cardioprotection in the isolated heart of the Wistar rat
… the release of the glycocalyx component syndecan-1 in the coronary effluent using enzyme-linked immunosorbent assay (ELISA) and determining relative syndecan-1 staining intensity between groups in immuno-stained wax sections of perfusion-fixed hearts. In addition, the histo-morphology of …
-
Investigating the integrity of the vasculature and structural relationships of pericytes, astrocytes and the endothelial glycocalyx in an ex vivo hyperglycaemic rat retinal model
… pericytes, astrocytes and the glycocalyx protein syndecan-1 with anti-neuron-glial 2 antigen (NG2), anti-glial fibrillary acidic protein (GFAP), and anti-syndecan-1 antibodies respectively. Retinal blood vessels were detected with FITC-conjugated lycopersicon esculentum (Tomato) lectin. …
-
Circulating proteoglycans and glycosaminoglycans during critical illness
… patients circulating levels of the proteoglycans syndecan-1 was increased compared to controls. No difference was detected between patients with different underlying conditions. This indicates that syndecan-1 release is a general consequence of critical illness that probably has limited value as a …
-
Mechanical Strain-Mediated Syndecan Regulation and Its Effects on Adhesion of Vascular Smooth Muscle Cells
… extracellular environment via regulation of the syndecan class of cell adhesion molecules dictates the response of the vascular wall to local injury. The effect of in vitro syndecan-4 regulation on SMC adhesion was investigated through the use of a glass microsphere centrifugation assay, and an …
-
Glycans in host-pathogen interactions : an integrated biochemical investigation
… (a large glycan- protein conjugate), syndecan-1 and on epithelial tight junctions. The findings presented in this work suggest mechanisms by which sphingomyelinases could enhance bacterial virulence by regulating epithelial cell function. The second part of the thesis investigates the …
-
Fluorous assisted one-pot oligosaccharide synthesis and chemical synthesis of homogeneous heparan sulfate proteoglycan
… Hpearan sulfate proteoglycans (HSPGs), including syndecans and glypicans, are ubiquitous components of mammalian cell surface and extracellular matrix and they play important roles in various biological processes such as cancer development, angiogenesis. viral infection and wound repair. They are …
-
Interactions of human immunodeficiency virus type 1 with mucosal epithelial surfaces and Candida albicans
… to promote HIV-1 binding, including GalCer and syndecan-1. Oral and vaginal epithelial cell models can capture HIV-1, which subsequently does not appear to integrate into the epithelial genome. Therefore, viral replication is not supported. Notably, HIV-1 captured on the epithelial surface …
-
Heparan Sulfate Proteoglycans in Pancreatic Ductal Adenocarcinoma (PDAC)
… a heparan sulfate proteoglycan (HSPG), Syndecan-1 (SDC1), as a key effector for pancreatic ductal adenocarcinoma (PDAC) progression whose surface expression is driven by KRAS*. By leveraging various PDAC models, we found that surface SDC1 expression was initially diminished upon mutant …
-
KSHV Susceptibility and Transmission Within Tonsillar Specimens
… targeting of plasma cells is not due to CD138 (Syndecan-1) being used as an attachment factor, and heparan sulfates, in general, do not play an important role in KSHV infection of B cells. Finally, the donor-dependent immunological factors and immune status of individual samples influences the …
-
Systems biology of endothelial mechano-activated pathways
… expression of a heparan sulfate proteoglycan, syndecan-1, is also differentially regulated by the two waveforms, and its suppression mutes the atheroprotective-flow-induced cell surface expression of heparan sulfate. Collectively, these data links distinct hemodynamic environments to the …
-
Regulation der terminalen B-Zell-Differenzierung durch Blimp-1
… mRNA, exprimieren den Plasmazellmarker Syndecan-1 auf ihrer Oberfläche und sezernieren für kurze Zeit IgM. Diese Differenzierungsprozesse gehen allerdings mit einem Wachstumsnachteil und Zellzyklus-Arrest, gefolgt vom Zelltod, einher. Blimp-1 exprimierende WEHI 231 Zellen zeigen somit …