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Showing 1 to 11 of 11 for “"synaptonemal complex"”.
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Investigating the control of pairing and crossover formation in meiosis of Arabidopsis thaliana
… pair and become connected by formation of the synaptonemal complex. Recombination is initiated by DNA double strand breaks (DSBs), formed by the protein SPO11-1. In Arabidopsis, ~10% of DSBs are repaired as crossovers, which are reciprocal exchanges of DNA between homologues. These physical …
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The examination of mechanisms underlying meiotic chromosome segregation
… a cohesin. Rec8 is important for assembly of the Synaptonemal Complex (SC) and meiotic prophase progression. Like Rec8's cohesin role, this prophase role appears to be influenced by Rec8 phosphorylation. Finally, I present a basic characterization of the process of homolog pairing in early …
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Epic Search for the Perfect Partner: MutSgamma Promotes Efficient Meiotic Recombination and Homolog Pairing in Mouse Spermatocytes
… by a proteinaceous structure called the synaptonemal complex. Synapsis is achieved much later in meiotic prophase than pairing, but is also necessary for efficient interhomolog recombination in budding yeast and mammals, confounding the interplay between recombination and pairing. The …
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MODELING INFERTILITY: SINGLE GENE MUTATIONS AND CONSEQUENCES FOR GERM CELL DEVELOPMENT
… I in mice. We found that TRIP13 localizes to the synaptonemal complex (SC) in pachynema and to meiotic telomeres throughout prophase I. Trip13-/- spermatocytes arrest in pachynema and exhibit defective synapsis. TRIP13 localization in other mutant strains with defective synapsis, indicated that …
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The Evolution of Recombination Landscapes and Mechanisms in Drosophila in Light of Intragenomic Conflict
… 1. In Chapter 2, I found evidence that the synaptonemal complex (SC), a protein complex necessary for proper meiotic recombination, is evolving rapidly in Drosophila due to positive selection. I proposed several hypotheses to explain the rapid evolution of the SC including the interaction …
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Discovery of a novel meiotic E3 ubiquitin ligase by characterisation of the barley desynaptic mutant <i>DES12.W</i>
… It is characterised by an abnormal synaptonemal complex during prophase I leading to improper chromosome segregation due to ‘sticky’ chromosomes causing chromosomal bridges and fragments. Immunocolocalisation experiments showed this to be a result of distal chromosomal entanglements …
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Chromosome dynamics during cell divisions in Drosophila melanogaster: The role of Rad21 in meiotic cohesion and dynamic analysis of the condensin subunit CapG in early embryonic mitotic divisions
… chromatid cohesion require multisubunit protein complexes, the condensin and the cohesin complexes, respectively. Both complexes are composed of two core SMC subunits and a set of non-SMC subunits, which are conserved among most eukaryotes. In the first part of my thesis, I have analyzed the …
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Whole genome approaches to identify genes involved in early meiosis.
… cell division. The meiotic pathway in plants is complex from multiple perspectives. From a mechanical view; prior to the first meiotic division the chromosomes must replicate during meiotic interphase, then while retaining sister chromatid cohesion the homologous chromosomes must align, …
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Polymerisationseigenschaften des Synaptonemalkomplexproteins SYCP1 und Charakterisierung von Bindungspartnern : Architektur meiotischer Chromosomen
Das Synaptonemalkomplexprotein SYCP1 ist eine Strukturkomponente des Synaptonemalkomplexes (SC) von Saeugern, einer meiosespezifischen Struktur, die wesentlich fuer die Synapse, Rekombination und Segregation homologer Chromosomen ist. Der SC besteht aus zwei lateralen Elementen (LEs) und einer …
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Lamin C2
… Akkumulationen. Überraschenderweise treten die Synaptonemal-komplexenden nur im Bereich dieser Lamin C2-Aggregate mit der Kernhülle in Kontakt. Es wird daher postuliert, daß die Lamin C2-Aggregate der lokalen Verstärkung der Kernhülle dienen und wichtig für die auf die Prophase beschränkte …