Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 73 for “"synaptic vesicles"”.
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Isolation and characterisation of synaptic vesicles from mouse brain
Alle Eukariotischen Zellen führen einen konstanten Transport von Membranekomponenten duch Vesikel zwischen den Subzellulären Kompartimenten durch. Ein klassichen Beispiel für diesen Transport sind synaptische Vesikel, welche eine wichtige Rolle in der Ausschüttung von Neurotransmitter spielen. …
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Interaction of alpha-synuclein with nanoscale systems that mimic synaptic vesicles
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01
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Genetic analysis of synaptogyrin function in the synaptic vesicle cycle
… relies on the continual replenishment of synaptic vesicles that are primed for neurotransmitter release in response to action potentials. A vast array of proteins is required to mediate synaptic vesicle biogenesis, trafficking, docking, exocytosis, and endocytosis. Synaptogyrin and …
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Molecular Determinants of Synaptic Vesicle Exocytosis and Endocytosis Coupling
Synaptic vesicle recycling is essential for maintaining normal synaptic function. The reuse of vesicles maintains the size of the presynaptic terminal and ensures the availability of synaptic vesicles for subsequent exocytosis. The coupling of exocytosis and endocytosis allows for continued rapid …
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Molecular Anatomy of a Living Nerve Terminal: Actin and Synapsin in the Synaptic Vesicle Cycle
… is based on a series of events termed the synaptic vesicle cycle. Several molecular components contributing to the synaptic vesicle cycle are known, including the cytoskeletal protein actin and the synaptic vesicle-associated phosphoprotein synapsin. The studies presented in this thesis …
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Genetic Dissection of Synaptic Vesicle Endocytosis
Synaptic transmission is mediated by the quantal release of neurotransmitters through the fusion of discrete synaptic vesicles with the presynaptic membrane. To maintain reliable transmission, synaptic vesicles and proteins must be recycled after release of neurotransmitters. A key protein in this …
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Exploring Synaptic Vesicle Exocytosis
… optical techniques to study determinants of presynaptic efficiency. Our methods are largely based on a chimera of a pH-sensitive variant of the green fluorescent protein and the vesicular glutamate transporter. This reporter is incorporated into synaptic vesicles and increases its fluorescence …
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The Role of Presynaptic Par-1 Kinase in Regulating the Localization of Active Zone Protein BRP
Precise localization of synaptic proteins is required for proper synaptic function, which is compromised in many neurodevelopmental and neurodegenerative diseases. Since proteins that reside at the active zones are used most frequently during synaptic transmission, they must be continuously …
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Molecular genetic characterization of the Drosophila synaptotagmin family
… the importance of calcium in regulating synaptic communication; however the molecular events underlying basic synaptic transmission and plasticity have only recently become the subject of intense investigation in neuroscience. The synaptotagmin family of vesicle proteins has been …
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Spontaneous and evoked vesicle cycling at a presynaptic terminal
The presynaptic vesicle cycle is crucial for chemical neurotransmission. In response to an action potential, neurotransmitter-filled vesicles are exocytosed from the pre-synaptic terminal and activate specific receptors at the post-synaptic membrane. To sustain neuronal activity, vesicles are then …
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The role of protein phosphorylation in the switching between modes of synaptic vesicle release
… stimulation and attention was focused on the presynaptic nerve terminal - by employing synaptosomes - for understanding the mechanisms occurring in synaptic vesicle exocytosis. Synaptic vesicles have rapid recycling capabilities and this in part may be due to a kiss-and-run mode of …
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Elucidation of the Specificity of Neuroactive Steroids and Related Compounds at the at the Vesicular Glutamate Transporter
… of the mammalian CNS. Proper regulation of the synaptic release of glutamate, potentially regulated by synaptic vesicle content, is one of many critical aspects to normal excitatory functioning. In particular, the vesicular glutamate transporters (VGLUTs), which load synaptic vesicles with …
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Elucidation of the Specificity of Neuroactive Steroids and Related Compounds at the at the Vesicular Glutamate Transporter
… of the mammalian CNS. Proper regulation of the synaptic release of glutamate, potentially regulated by synaptic vesicle content, is one of many critical aspects to normal excitatory functioning. In particular, the vesicular glutamate transporters (VGLUTs), which load synaptic vesicles with …
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Automated detection of ultrastructural features at neuronal synapses
Synaptic vesicles are the ultracellular structures responsible for carrying chemical messengers known as neurotransmitters from inside the axon of a neuron to the synaptic junction outside. The variation in size and location of these structures is important in the study of their use and reuse in …
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Regulation of Synaptic Vesicle Trafficking at Central Synapses
… inter-neuronal communication in the brain. At presynaptic terminals, synaptic vesicles fuse with plasma membrane in response to electrical stimulation, followed by rapid retrieval to the terminal and re-organization for reuse. Thus, synaptic vesicle trafficking is of interest as to where …
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Understanding the role of cholinergic tone in the pedunculopontine tegmental nucleus
… al., 2009). VAChT stores acetylcholine (ACh) in synaptic vesicles, and changes in this transporter expression directly interferes with ACh release. Here, we use a mouse line with VAChT deletion in the pedunculopontine tegmental nucleus (PPT) to evaluate the consequences of decreased cholinergic …
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Axon Guidance Autonomy and Tensional Requirement for Synaptic Function: Is Learning a Forced Response
… as they extend, navigate and target postsynaptic partner cells normally. After detachment, the growth cones continue to synthesize the synaptic vesicle protein Synaptotagmin but, upon contacting targets, fail to concentrate it at the presynaptic site normally. However, if held by a …
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A genetic analysis of complexin function in neurotransmitter release and synaptic plasticity
… synapses requires rapid fusion of docked synaptic vesicles in response to calcium influx during action potentials. The molecular nature of the fusion clamp machinery that prevents exocytosis of synaptic vesicles in the absence of a calcium signal is still unclear. Here we show that …
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The vesicular glutamate transporter (VGLUT): heterologous expression, proteoliposome, computational and mass spectral studies
… membrane proteins that uptake glutamate into synaptic vesicles and are involved in glutamatergic neurotransmission. Since VGLUTs were identified and cloned, efforts have been made to characterize their functional roles. However, due to experimental limitations, the structural features of VGLUT …
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