Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"synaptic vesicle protein"”.
-
Synaptic vesicle protein 2A-dependent function and dysfunction at the presynapse
… for neuronal communication. At the presynapse, synaptic vesicles (SVs) undergo exocytosis to release neurotransmitter in response to incoming action potentials, and endocytosis to maintain the supply of SVs needed for further rounds of exocytosis. A key event during SV endocytosis is the …
-
Identification, Characterization, and Developmental Analyses of A Growth Cone Specific Epitope and a Synaptic Vesicle Protein
… a growth cone specific epitope (CD'A 1), a synaptic vesicle antigen (SVP38), and the developmental expression of each in various tissues. Although CD'A 1 and SVP38 do not have any direct relationship to each other, I will show that the expression of both changes over the same time period. …
-
Axon Guidance Autonomy and Tensional Requirement for Synaptic Function: Is Learning a Forced Response
… components, and are capable of synthesizing protein locally. However, the extent to which growth cone's autonomy contributes to its pathfinding function within the complex in vivo environment is unknown. Here, we show that detached axonal growth cones from identified Drosophila motoneurons …
-
STED microscopy in the visible range
… with the green and yellow fluorescent proteins (GFP, YFP) which are endogenous cellular markers of outstanding biological importance. The spectral conditions for STED with these fluorophores are given. The expansion of STED to the visible range has enabled the first application to …
-
Unraveling the Role of SNARE Interactions in Neurotransmitter Release
… release of neurotransmitters by Ca2+-triggered synaptic vesicle exocytosis is tightly controlled by an intricate protein machinery. Essential components of this machinery are the synaptic vesicle protein synaptobrevin and the plasma membrane proteins syntaxin 1 and SNAP-25, which are …
-
Investigating the physiological function of Alzheimer’s disease risk gene Abca7 in the central nervous system
… and subcellular localization of the Abca7 protein in vivo and (2) the identification of gene and gene pathways in which Abca7 is involved (Chapters 2 and 3). Abca7 is expressed throughout neurodevelopment into adulthood and is ubiquitously expressed and localizes to membranes and synaptic …
-
Reevaluating the functional role of the C₂A domain of synaptotagmin in neurotransmitter release
… of the nerve terminal, Ca2+ enters the presynaptic cell and drives fusion of vesicles with the membrane, releasing neurotransmitter. The synaptic vesicle protein, synaptotagmin, was identified as the Ca2+ sensor for this fast, synchronous neurotransmitter release. It is hypothesized that …
-
Novel Optical Tools to Investigate Presenilin Control of Neurotransmission
… the complex processes of the brain. Deficits in synaptic function often manifest in neurodegenerative diseases, motivating the study of control points of neurotransmission. The Endoplasmic Reticulum (ER) has recently been described as one such control point, as ER Ca<sup>2+</sup> levels can …
-
Role of Synapsin In Long-Term Synaptic Facilitation In Aplysia
<p> <p>Enhanced expression of the presynaptic protein synapsin has been correlated with certain forms of long-term plasticity and learning and memory. However, the regulation and requirement for enhanced synapsin expression in long-term memory remains unknown. In the present study the technical …
-
The Addicted Phenotype: Protein Phosphorylation Status and Dopamine Receptor Responsiveness
… alterations in cAMP-dependent and -independent protein phosphorylation in vivo produced by chronic cocaine and heroin self-administration, changes in mesolimbic protein phosphorylation compared to individual differences in the propensity for escalating cocaine self-adminstration, and, …