Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"synaptic targeting"”.
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Synaptic Targeting of Neurotransmitter Receptors is Regulated by Neurobeachin
Informationen in neuronalen Netzwerken werden hauptsächlich durch chemische Synapsen vermittelt. In der Regel erhält eine Nervenzelle tausende von ankommenden Signalen von anderen Neuronen. Durch die Aktivierung einer großen Anzahl von Rezeptormolekülen in der postsynaptischen Membran werden diese …
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Study of Presynaptic Calcium Channels and a Novel Calcium Channel Calhm1
… In brain these processes include basic synaptic transmission, modification of established synapses, elimination of synapses as well as elimination of whole neurons by way of apoptosis. In this thesis, we have studied two of these processes. One process is synaptic targeting of …
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Analysis of Postsynaptic Morphology During Neuromuscular Synaptogenesis in Drosophila Melanogaster
… vast numbers of individual cells. Pre- and postsynaptic cells use a variety of molecular cues to recognize one another. Changes in presynaptic cell morphology during encounters with these environmental cues has been well-documented, while postsynaptic cells have traditionally been regarded as …
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Inhibition, Synapses, and Spike-Timing: Identification and disruption of pyramidal cell-interneuron interactions in SPW-Rs
… interneurons, with variation in gene expression, synaptic targeting, state-dependent activity, and connectivity, contribute substantially to circuit activity, such as theta and sharp wave-ripple oscillations. The precise roles of each interneuron group is not well understood, though …
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Specifying molecular determinants of the subcellular targeting of synaptic and extrasynaptic GABA A receptors
… expression and sub-membrane segregation of synaptic and extrasynaptic GABA-A receptors. My data demonstrate that the synaptic targeting of g2-containing GABA-A receptors does not depend on the cytoplasmic TM3-TM4 domain of the g2 subunit. This result was actually surprising, until Alldred et …
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Growth Cone Pathfinding and Neuromuscular Synaptogenesis in Drosophila Midline Mutants
… at the midline, subsequent pathways and synaptic targeting in all cases were the perfect mirror-images of those seen in wildtype. This suggests that a growth cones' particular molecular experience and decision at the midline does not affects its ability to respond normally to subsequently …
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Cellular mechanisms that modulate kainate receptor trafficking and assembly
… assembly, intracellular trafficking, and synaptic targeting. Cytoplasmic and non-cytoplasmic determinants that modulate KAR expression at the plasma membrane have been recently characterized. The intracellular trafficking determinants are presumed to bind to chaperone proteins, but these …
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Regulation of Molecular Composition at Glutamatergic Synapses
Proper targeting and clustering of synaptic molecules is necessary for the formation of functional glutamatergic synapses. Here I examined the clustering of presynaptic (Brain-Specific L-Proline Transporter, PROT) and postsynaptic (N-Methyl-D-Aspartate Glutamate Receptor, NMDAR) molecular markers …
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EGFR signaling regulates synaptic connectivity via Gurken
… or epilepsy. To identify novel regulators of synaptic development, I screened for mutants with defects in synaptic morphology and growth at the Drosophila larval neuromuscular junction: NMJ). My screen identified several mutants with defects in various aspects of synaptic development. I …
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Unmasking Impulsivity as a Glutamatergic Dysfunction Phenomenon: Presynaptic and Postsynaptic Considerations
… studies that aimed to examine glutamatergic presynaptic and postsynaptic neural substrates in key brain regions underlying motor impulsivity. Impulsivity is thought to be a function of a cortical imbalance that results in excessive “go” signaling (i.e. loss of inhibitory control). We discovered …