Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 50 for “"synaptic strength"”.
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Scaling of unitary synaptic strength in the context of network dynamics
… is determining what sets the unitary functional strength of a synaptic connection between two cells, and what meta-processes such mechanisms answer to. This question can be asked either mechanistically, by characterizing the molecular processes that regulate the synapse's transmission, or …
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Investigating the Role of Drosophila Tomosyn in Synaptic Strength and Plasticity
… of SNARE assembly that occurs at specialized presynaptic subdomains in response to transient calcium influx following an action potential. SV fusion from the presynaptic terminal results in a postsynaptic response that varies in size depending on synaptic strength. Both the postsynaptic and …
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The development of functional inputs to a neural circuit : synaptic strength before and after the activity-dependent maturation of the retinogeniculate system
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 1999.
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Coordination between presynaptic and postsynaptic properties measured at single terminals in hippocampal cultures
I examined the spatial scale at which pre-synaptic activity interacts with synaptic strength and developmental events in the post-synaptic cell. I performed this work in primary hippocampal cultures of postnatal Sprague-Dawley rats after 8-10 days in vitro. I measured electrophysiologically the …
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The role of auditory sensory input during functional pre- and postsynaptic maturation of the calyx of Held synapse
… this question we exploited the distinct presynaptic Ca2+ channel subtypes governing transmitter release at the cochlear inner hair cell (IHC)-spinal neuron synaptic junction compared to those at higher synapses along the auditory pathways. We characterized functional properties of calyx …
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WWC2 Is a Novel Regulator of GABAAR Expression, Synaptic Function, and Dendritic Morphology in Excitatory Hippocampal Neurons
… that WWC2 loss leads to dysregulated baseline synaptic function and decreased dendritic branching in hippocampal neurons. Preliminary studies indicate that CA1 pyramidal cells from WWC2 KO animals exhibit a trend toward increased stubby spine representation on basal dendrites. Additionally, I …
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Neurobiological mechanisms underlying episodic memory retrieval
… although these engram cells lacked augmented synaptic strength and dendritic spine density. We proposed that a specific pattern of connectivity of engram cells may be the crucial substrate for memory information storage and that augmented synaptic strength and spine density critically …
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Novel roles of striatal enriched protein phosphatase (STEP) in neuronal intrinsic properties and homeostatic synaptic plasticity
… diseases. STEP61 regulates Hebbian forms of synaptic plasticity, which has been considered as a mechanism by which the information is encoded and stored at the synapse. STEP61 is involved in the internalization of the N-methyl-D-aspartate receptors (NMDARs) and the …
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Strength and dendritic organization of thalamocortical synapses onto excitatory layer 4 neurons
… filtering does not appreciably favor one synaptic class over another. Measurements of synaptic strength in intact animals revealed that both TC and CC synapses are weak and approximately equivalent. We conclude that thalamic potency relies, not on enhanced TC strength, but on coincident …
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The role of Polo-like kinase 2 in synaptic function and plasticity
… Polo-like kinase 2 (Plk2), was required for synaptic scaling in dissociated culture and for reducing membrane excitability in slice culture-two principal compensatory mechanisms underlying homeostatic plasticity. Inhibition of Plk2 activity in slice culture during elevated activity resulted …
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A Purkinje cell Timing Mechanism. On the Physical Basis of a Temporal Duration Memory.
… or inhibiting it. Learning is thought to involve strengthening or weakening synaptic connections. For most behaviors, the brain must learn to produce precisely timed activity patterns. Learned response timing is indispensable for a wide range of tasks and requires learning of interstimulus …
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Tracking Light-Induced Synaptic Engrams in in-vitro Neuronal Networks
The concept that activity-dependent synaptic plasticity is at the core of learning and memory is a cornerstone of neuroscience. This intricate process entails synapses' capacity to adjust their strength in reaction to neural circuit activation, facilitating the nervous system's adaptation to …
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The role of neurogranin in modulating contextual memory and plasticity : FMRP involvement and adrenergic-dependent facilitation
… memory formation and the long-lasting changes in synaptic strength that accompany learning. However, it's still unclear when protein synthesis needs to occur relative to the experience to form durable memories, and the identities and roles of crucial proteins in these processes have not been …
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The regulation of neuronal excitability by epilepsy-associated gene Nedd4-2
… nervous system, mediating fast excitatory synaptic transmission. Their distribution and activity are regulated by post-translational modifications, such as ubiquitination and phosphorylation. Studies have shown that GluA1 ubiquitination contributes to its internalization, which, as part of …
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Temporal synchronization of CA1 pyramidal cells by high-frequency, depressing inhibition, in the presence of intracellular noise
… techniques are proven. The effects of synaptic strength, synaptic recovery, and inhibition frequency are discussed. In contrast to prior work, which suggests that the ripple is produced by homogeneous populations of either pyramidal cells or interneurons, the results presented here …
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Stretch induced hyperexcitability of mice callosal pathway
… learning are thought to result from changes in synaptic strength. Previous studies on synaptic physiology in brain slices have traditionally been focused on biochemical processes. Here, we demonstrate with experiments on mouse brain slices that central nervous system plasticity is also sensitive …
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Ca2+ dependant synaptic modification
… LTP have been 1. tetanic stimulation of presynaptic cell, 2. theta burst stimulation of presynaptic cell, and 3. correlated stimulation of pre- and post-synaptic cells. However, the effects of different Ca2+ influx can not be precisely dissected with the conventional protocols for the …
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Role of galanin in synaptic transmission and plasticity in the CA1 area of the rodent hippocampus
… in vivo. The sustained increase in glutamatergic synaptic strength following high frequency stimulation of hippocampal neurones, a phenomenon termed long-term potentiation (LTP), has been widely recognised as a model ofthe synaptic changes that may underlie learning and memory in vertebrates. It …
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Super-resolution imaging of glutamate receptors in cultured hippocampal neurons under basal and LTP conditions
The locations and dynamics of glutamate synaptic receptors—the AMPA receptors (AMPARs) and NMDA receptors (NMDARs)—located on the postsynaptic membrane of nerve cells, are crucial for neuronal health, learning and memory formation. They can exist under basal condition where no synaptic strength …
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Functional role of NMDA receptor subunit composition in metaplasticity
… after brain damage. In the visual cortex, the strength of cortical synapses can be bidiredionally modified, where in response to a critical level of postsynaptic activation, synapses are strengthened (long-term potentiation; LTP) and below this level, synapses are weakened (long-term …
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