Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"synaptic specificity"”.
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Visualizing Synaptic Specificity with GRASP
… precision as it selects a unique ensemble of synaptic partners from a vast array of potential targets. Visualization of individual synapses in the central nervous system is difficult in some contexts and impossible in others, and the ability to rapidly monitor connectivity in living animals …
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Synaptic Specificity in the Zebrafish Lateral Line
… billions of neurons to select their appropriate synaptic targets. In view of this complexity, simple vertebrate systems provide necessary models for understanding how synaptic specificity arises. The posterior lateral-line organ of larval zebrafish consists of polarized hair cells organized in …
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Filopodial Dynamics and Synapse Specification in the Drosophila Visual System
How is the synaptic specificity achieved in neural circuits comprised of hundreds of different types of neurons? My dissertation aims to advance our knowledge on this overarching question using the complex visual processing circuitry of D. melanogaster. This system not only provides excellent …
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Dopaminergic Modulation Shapes Sensorimotor Processing in the Drosophila Mushroom Body
… to the mushroom body in order to adjust synaptic connectivity between Kenyon cells, the neurons representing olfactory stimuli, and the mushroom body output neurons that ultimately influence behavior. However, we still lack a mechanistic understanding of how the dopaminergic neurons …
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Development of neuronal connectivity in the central nervous system of Drosophila melanogaster
… project to remote locations in search of their synaptic partners. Surrounded by numerous cells along their trajectory and in their target area, these developing neurons ignore most neurons with which they come into contact and connect with very specific partners. The mechanisms by which …
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Synaptic Protein Profiling in the Mammalian Brain
… billions of neurons each receiving thousands of synaptic inputs. Synapses are specified in part through the precise localization of synaptic proteins, yet it has not previously been possible to analyze the protein content of an individual class of synapses. In order to achieve this, we have used …