Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"synaptic release"”.
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Synaptic Specificity in the Zebrafish Lateral Line
… billions of neurons to select their appropriate synaptic targets. In view of this complexity, simple vertebrate systems provide necessary models for understanding how synaptic specificity arises. The posterior lateral-line organ of larval zebrafish consists of polarized hair cells organized in …
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A Comparative Study of Sensory Neuron Synaptic Activity and the Role of Presynaptic Diversity, Specificity, and Regulation in Caenorhabitis Elegans
… circuit functions, we sought to characterize synaptic release in the stereotyped and defined neural circuitry of C. elegans. Here we use pHluorin imaging (Vglut-pH) to monitor presynaptic glutamate release from single chemosensory neurons in intact animals and characterize the dynamics of …
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Evidence for effects of phoenixin on neurons of the paraventricular nucleus
… to regulation of reproductive and stress hormone release. Recently, specific stress-related effects of this peptide in the nucleus of the solitary tract (NTS) have been demonstrated. In this study we investigated the effects of PNX on PVN neuronal activity using in vitro extracellular recordings. …
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Calcium Triggered Synaptic Vesicle Exocytosis
Neurotransmitter release is triggered by the action potential induced influx of Ca 2+ into nerve terminals. One of the central questions in neuroscience is how Ca 2+ promotes synaptic vesicles from rest to fusion leading to release of neurotransmitters. In this thesis, I first addressed if …
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Elucidation of the Specificity of Neuroactive Steroids and Related Compounds at the at the Vesicular Glutamate Transporter
… of the mammalian CNS. Proper regulation of the synaptic release of glutamate, potentially regulated by synaptic vesicle content, is one of many critical aspects to normal excitatory functioning. In particular, the vesicular glutamate transporters (VGLUTs), which load synaptic vesicles with …
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Elucidation of the Specificity of Neuroactive Steroids and Related Compounds at the at the Vesicular Glutamate Transporter
… of the mammalian CNS. Proper regulation of the synaptic release of glutamate, potentially regulated by synaptic vesicle content, is one of many critical aspects to normal excitatory functioning. In particular, the vesicular glutamate transporters (VGLUTs), which load synaptic vesicles with …
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Frequency Selectivity of Synaptic Exocytosis in Hair Cells of the Bullfrog's Amphibian Papilla
… that lacks a basilar membrane. We monitored the synaptic output of hair cells by measuring changes in their membrane capacitance in response to sinusoidal electrical stimulation. Using perforated-patch recordings, we found that individual hair cells display frequency selectivity in synaptic …
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The Role of the Stereociliary Glycocalyx in Hair Bundle Cohesion
… in and depolarize the cell membrane triggering synaptic release at the base of the cell, and consequently sending the information to the brain. The cell membranes in the hair bundle face a difficult task when the bundle oscillates in response to sound. For efficient auditory mechanotransduction, …
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THE MECHANISMS AND PHARMACOLOGY OF NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS IN THE CENTRAL NERVOUS SYSTEM
… the pharmacology and mechanisms of action of pre-synaptic non-α7 and α7 nAChRs in the caudal NTS neurons. Although, activation of nAChRs is known to enhance pre-synaptic release of glutamate in subsets of caudal NTS neurons, its mechanism of action has been elusive. However, the results from this …