Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 34 for “"synaptic proteins"”.
-
Molecular mechanisms of synaptic proteins
Synaptic adhesion molecules (SAMs) are critical for regulating synapse development and synaptic plasticity. Many studies have linked their putative roles in neuropsychiatric and neurodevelopmental diseases, such as schizophrenia and autism spectrum disorder. Here, the structure-function …
-
Molecular mechanisms of synaptic proteins
Synaptic adhesion molecules (SAMs) are critical for regulating synapse development and synaptic plasticity. Many studies have linked their putative roles in neuropsychiatric and neurodevelopmental diseases, such as schizophrenia and autism spectrum disorder. Here, the structure-function …
-
Neuromuscular Synaptic Proteins In Development And Regeneration
… axons. I find that this process requires the synaptic receptor lrp4 and that in lrp4 mutants pioneer axon regrowth is unaffected while follower axons frequently stall at the site of injury, providing evidence for molecular diversity between pioneering and follower axons during regeneration. I …
-
Enzyme mediated labeling of synaptic proteins for proteomics and imaging
… knowledge of the molecular components of the synaptic cleft, the gap space between the pre and postsynaptic neuron, hindering a complete mechanistic understanding of this structure. This is because the cleft is extracellular and non-membrane bound, and hence intractable to biochemical …
-
Synaptic Protein Profiling in the Mammalian Brain
… billions of neurons each receiving thousands of synaptic inputs. Synapses are specified in part through the precise localization of synaptic proteins, yet it has not previously been possible to analyze the protein content of an individual class of synapses. In order to achieve this, we have used …
-
The effect of HIV-1 Tat and methamphetamine on expression of cytokines/chemokines and synaptic genes: Implications in HIV neuroAIDS
… been attributed to the virus itself or the viral proteins like HIV-1 Tat shed after the infection via several mechanisms including production of cytokines/chemokines and decreased expression of neuroplasticity genes. The present study was based on the central hypothesis that HIV-1 Tat and …
-
Fluorescence fluctuation spectroscopy and microscopy : application to cellular molecular dynamics and organization
… highly multiplexed super-resolution imaging of synaptic proteins. We employed DNA-PAINT to resolve nano-scale organization of seven targets simultaneously including synaptic proteins and cytoskeletal markers. These approaches demonstrated the broad applicability of fluorescence fluctuation …
-
The Role of CASK in Central Nervous System Function and Disorder
… through interactions with both active zone proteins and trans-synaptic adhesion molecules such as liprins-α and neurexins. Mutations in the X-linked CASK gene in humans are largely post-natally lethal in the hemizygous condition and result in microcephaly with pontine and cerebellar …
-
Identification and functional characterisation of synaptic AMPA receptor-interacting proteins
… at specialised sites, known as synapses. Presynaptic neurotransmitter release from one neuron acts on the postsynaptic receptors of another, facilitating transfer of electrical impulses between neurons. At glutamatergic synapses, ionotropic glutamate receptors (iGluRs) respond to …
-
Understanding Neuronal Autophagic Lysosomal Pathways Through Genetic and Pharmacological Perturbations
… is associated with decreased mitochondrial and synaptic proteins in axons. Further, our results suggest that JIP3 has functions in the endolysosomal system in the soma. Finally, we observed that mitigating JIP3 pathology by increasing autophagic flux can rescue transport deficits and elevated Aβ …
-
Consuming a diet enriched with choline, UMP, and DHA improves memory in rodents when these compounds increase phospholipids
… treatment tested in laboratory animals increases synaptic membrane and cholinergic neurotransmission. This treatment involves giving three compounds; DHA, a phosphatide precursor; choline, another phosphatide precursor present in the rodents' diets but not varied in this study; and UMP, a …
-
The Role of Presynaptic Par-1 Kinase in Regulating the Localization of Active Zone Protein BRP
Precise localization of synaptic proteins is required for proper synaptic function, which is compromised in many neurodevelopmental and neurodegenerative diseases. Since proteins that reside at the active zones are used most frequently during synaptic transmission, they must be continuously …
-
Cell-Free Formation of RNA Granules
… as well as establishment of cell polarity and synaptic plasticity in the brain. In many instances, asymmetric RNA localization is achieved through transport and sequestration by RNA granules. RNA granules are large, non-membrane bound ribonucleoparticles that have been observed in various …
-
Regulation of mGluR7 trafficking by SUMOylatio in neurons
… by which SmallUbiquitin-like MOdifier (SUMO) proteins are covalently linked to the lysine residues of target proteins via an enzymatic cascade. It has been reported that SUMOylation of synaptic proteins plays important regulatory roles in synapse formation, axonal mRNA transport, channel …
-
Synaptic Specificity in the Zebrafish Lateral Line
… billions of neurons to select their appropriate synaptic targets. In view of this complexity, simple vertebrate systems provide necessary models for understanding how synaptic specificity arises. The posterior lateral-line organ of larval zebrafish consists of polarized hair cells organized in …
-
The Role of Gene Regulation in Neural Circuit Development: Studies in the Zebra Finch
… First, the expression of genes encoding synaptic proteins was measured by in situ hybridization during the ""critical period"" for song learning in the motor control pathway. Three genes: canarigranin, GAP-43 and synelfin were tested, and changes in mRNA level were observed in all three …
-
Expansion microscopy of C. elegans : nanoscale imaging of biomolecules throughout an entire organism
… quantification of biomolecules and mapping of synaptic contacts, to be performed within the context of an entire nervous system. The nematode Caenorhabditis elegans could be a suitable model for such organism-wide analyses, due to its tractable physical size, deterministic cell lineage, ease of …
-
Persistent “hijacking” of brain proteasomes in HIV-associated dementia
… in neurons was investigated with the analysis of synaptic proteins. Decreases in synaptophysin correlated with immunoproteasome increases, indicating the potential for synaptic protein alterations associated with immunoproteasomes. Analysis of isolated nerve endings, or synaptosomes, revealed …
-
Structure-Function and Behavioral Studies on the Glutamate Delta-1 Receptor
… neuropsychiatric disorders. We hypothesize that synaptic abnormalities due to GluD1 deletion would lead to aberrant behaviors. Thus we performed tests in GluD1 knockout (GluD1 KO) mice to study the functional significance of the GluD1 receptor. GluD1 KO mice showed hyperactivity, lower …
-
Organization of Postsynaptic Proteins via the Neuronal Cytoskeleton
… for anchoring molecular components of postsynaptic specializations in the mammalian brain are not well understood but are presumed to involve associations with cytoskeletal elements. We used cytoskeletal perturbing agents and detergent extraction of primary hippocampal cultures to test …
Page 1 of 2