Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 274 for “"synaptic plasticity"”.
-
Immunological investigations into synaptic plasticity
Antibody technology was applied to the study of synaptic plasticity resulting from passive avoidance training in the chick and long-term potentiation in the rat. These studies fell into three categories: 1) the disruption of memory for a one-trial passive avoidance task by intracranial injection of …
-
Molecular mechanisms of synaptic plasticity
Synaptic plasticity serves as a central molecular mechanism underlying learning and memory formation in the brain. An increase in intracellular calcium concentrations triggered by neuronal activity induces synaptic plasticity, and calmodulin is a key protein that detects the elevated calcium levels …
-
Induction and Maintenance of Synaptic Plasticity
Synaptic long-term modifications following neuronal activation are believed to be at the origin of learning and long-term memory. Recent experiments suggest that these long-term synaptic changes are all-or-none switch-like events between discrete states of a single synapse. The biochemical network …
-
Differential Regulation of Synaptic Plasticity In Epilepsy
… comorbidities. Examining alterations in synaptic plasticity can give us insight into the epileptogenic phenotype as well as accompanying conditions like cognitive decline and psychosis that may be observed in subjects with TLE. We decided to investigate changes in long term potentiation …
-
Mechanisms of Synapse Formation and Synaptic Plasticity
… the precise orchestration of both pre- and postsynaptic differentiation of synaptic machinery. However, the precise time course of synaptogenesis, and the role of extrinsic factors in synapse formation remains unclear. To examine the time course of synaptogenesis, I developed a novel “growth …
-
Synaptic plasticity in the MyosinVa mutant mouse
… proteins into spines is an important aspect of synaptic plasticity. MyosinVa, an actin-based motor protein, has been implicated in the synaptic delivery of AMPARs during LTP [1]. However an earlier study showed that LTP and LTD were unaffected in the MyosinVa-null dilute-lethal mice [2]. To …
-
S-nitrosylation mediates synaptic plasticity in the retina
… we report a novel form of activity-dependent synaptic plasticity via S-nitrosylation: a “weighted potentiation” that selectively increases the output of Mb-type bipolar cells in the goldfish retina in response to weak inputs but leaves the input-output ratio for strong stimuli unaffected. …
-
Methamphetamine, interleukin-6 and perineuronal nets in synaptic plasticity
… the strength and integrity of neurons and their synaptic connections. Neuronal synapses allow for the flow of information that enhances cellular communication. The plasticity of these synapses essentially drives activity-dependent learning and memory. This plasticity may be enhanced and/or …
-
tDCS effects on synaptic plasticity and motor skill learning
<p>Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that involves the application of low-intensity constant current to the brain through electrodes placed on the scalp. Its potential to enhance brain function and treat brain-related disorders has led to …
-
PROTEASOME REGULATES TRANSCRIPTION AND TRANSLATION IN LONG-TERM SYNAPTIC PLASTICITY
Long-term synaptic plasticity, which underlies long-term memory, depends on new gene transcription, new protein synthesis, as well as proteolytic degradation of regulatory proteins by the ubiquitin-proteasome pathway (UPP). To study the molecular mechanisms of learning and memory, we use the late …
-
Novel roles of the endocannabinoid system in modulating synaptic plasticity
… control these phenomena are largely unknown. Synaptic plasticity, which is the ability of the synapse between two neurons to change in strength based on activity, is believed to be a key process in the formation of memories and learning. Endocannabinoids (eCB) have recently emerged as …
-
Novel roles of the endocannabinoid system in modulating synaptic plasticity
… control these phenomena are largely unknown. Synaptic plasticity, which is the ability of the synapse between two neurons to change in strength based on activity, is believed to be a key process in the formation of memories and learning. Endocannabinoids (eCB) have recently emerged as …
-
The Role of Rac1 in Synaptic Plasticity, Learning and Memory
… and cytoarchitectural remodeling, referred to as synaptic plasticity. Changes in the morphology of synapses are necessary for learning and memory storage, and require the rearrangement of the actin cytoskeleton at dendrites and actin rich dendritic spines which are the loci excitatory of synaptic …
-
Effects of weak electric fields on long-term synaptic plasticity
… discussed mechanism is that tDCS may alter synaptic plasticity, but the biophysics that support this interaction between tDCS and synaptic plasticity remain unclear.</p> <p>This dissertation is centered around a fundamental hypothesis; that tDCS can modulate the brain’s ongoing endogenous …
-
Analog VLSI circuit design of spike-timing-dependent synaptic plasticity
Synaptic plasticity is the ability of a synaptic connection to change in strength and is believed to be the basis for learning and memory. Currently, two types of synaptic plasticity exist. First is the spike-timing-dependent-plasticity (STDP), a timing-based protocol that suggests that the …
-
Neuromuscular Junctions in Androgen Sensitive Muscles: A Model for Synaptic Plasticity
… well as in total activity. To quantify the postsynaptic effects of androgens, I measured acetylcholine receptor number (AChRs). AChR number was androgen-sensitive in both the syrinx and levator ani, decreasing after castration of males, and increasing in response to treatment with testosterone. …
-
Role Of The α1A-Adrenergic Receptor In Synaptic Plasticity, Cognition & Neurogenesis
… ANG underlies enhanced learning, memory and synaptic function. We used CRZ to activate α1A-ARs and the anti-mitotic agent cytosine arabinoside (Ara-C) to impair ANG in CRZ-treated and WT mice, and tested mice on novel object recognition (NOR), Morris water maze (MWM), and open field (OF). No …
-
Pannexin-1 modulates short-term synaptic plasticity by facilitating endocannabinoid transport
… outside of reported involvement in modulating synaptic plasticity in the form of long-term potentiation and long-term depression. The mechanisms by which Panx1 contributes to synaptic physiology are largely unknown. Its high expression in many brain regions (including the hippocampus), …
-
Synaptic Plasticity in the Cerebral Cortex of Fragile X Knockout Mice
… but Fmr1 knockout mice exhibited levels of synaptic protein synthesis lower than those of wildtype mice. The role of FMRP in experience-dependent brain plasticity was also assessed. FMRP expression in the rat occipital cortex increases following exposure to a complex environment, but …
Page 1 of 14