Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"synaptic neurotransmission"”.
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An In Vitro Characterization of the Raphe Nucleus and the Effects of SSRIs on Synaptic Neurotransmission
… inhibit the reuptake of neurotransmitters in the synaptic terminal by blocking the serotonin and norepinephrine transporters, clinical efficacy can take several weeks. This phenomenon implies that antidepressants not only target neurotransmitter transporters, but have secondary down-stream effects …
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The synthesis and pharmacological evaluation of quisqualic acid and some novel excitatory amino acid mimetics
… to be the principal initiators of excitatory synaptic neurotransmission in the mammalian central system. A number of molecules of either natural or synthetic origin have been identified as possessing agonist or antagonist properties at glutamate binding sites. One of the most potent agonist is …
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Understanding the activation-deactivation mechanism of glutamate receptor proteins at the single molecule level
… at the neuronal membrane and mediate excitatory synaptic neurotransmission in the mammalian central nervous system. These receptor proteins, such as NMDA and AMPA receptors, are structurally diverse and house multiple extracellular and intracellular binding sites, which can modulate activated …
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Antioxidants in Normal and Epileptic Brain: Effect on Synaptic Plasticity, Neural Network Physiology, and Memory
… learning and declarative memory, undergoes synaptic plasticity-augmented neuronal activity generating elevated amounts of reactive oxygen species (ROS) which plays key roles in functional and structural plasticity. Thus, this doctoral dissertation will investigate the role of antioxidants in …
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Membrane Lipids and Synaptic Vesicle Trafficking in the CNS
… a synapse are dormant. The rest participate in synaptic neurotransmission, with a portion of these preferentially fusing first. Moreover, all synapses experience spontaneous neurotransmitter release which may originate from the random exocytosis of vesicles prepared to fuse immediately upon …
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Characterization of a Chlamydomonas protein involved in cell division and autophagy
… physiological processes in animals, such as synaptic neurotransmission and blood filtration in the kidney, are related to the CV's function; and several pathogens, such as the causative agents of sleeping sickness, possess CVs, which may serve as pharmacological targets. The green alga …
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Genetic Dissection of Synaptic Vesicle Endocytosis
Synaptic transmission is mediated by the quantal release of neurotransmitters through the fusion of discrete synaptic vesicles with the presynaptic membrane. To maintain reliable transmission, synaptic vesicles and proteins must be recycled after release of neurotransmitters. A key protein in this …
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Elucidation of the Specificity of Neuroactive Steroids and Related Compounds at the at the Vesicular Glutamate Transporter
… of the mammalian CNS. Proper regulation of the synaptic release of glutamate, potentially regulated by synaptic vesicle content, is one of many critical aspects to normal excitatory functioning. In particular, the vesicular glutamate transporters (VGLUTs), which load synaptic vesicles with …
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Elucidation of the Specificity of Neuroactive Steroids and Related Compounds at the at the Vesicular Glutamate Transporter
… of the mammalian CNS. Proper regulation of the synaptic release of glutamate, potentially regulated by synaptic vesicle content, is one of many critical aspects to normal excitatory functioning. In particular, the vesicular glutamate transporters (VGLUTs), which load synaptic vesicles with …
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Molecular pharmacology of an insect GABA receptor
… ion channels that are involved in fast synaptic neurotransmission in the central and peripheral nervous system. The Cys-loop receptor RDL (‘resistant to dieldrin’) is a GABA-gated chloride channel from Drosophila melanogaster and is a major target site for insecticides. The aim of this …