Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"synaptic integrity"”.
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The Heparan Sulfate Proteoglycan Perlecan Regulates Axonal and Synaptic Stability
… ECM-localized HSPG that contributes to tissue integrity and cell-cell communication. In this thesis, I identify a role for Drosophila Perlecan in the maintenance of larval motoneuron axonal and synaptic stability. In Chapter 1, I discuss known roles for Perlecan and other HSPGs in animal …
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Alpha Synuclein Oligomers in Human Pathology: Significance of Nitrative Alpha Synuclein Modifications
… in transcription factor pCREB, which disrupts synaptic integrity and memory. This phenomenon is observed in vitro, ex vivo, and in vivo and results in deficits in LTP, synaptic plasticity, and memory function. On this basis, I tested the hypothesis that similar effects on synaptic signaling can …
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Hdac6 Inhibition Reverses Long-Term Doxorubicin-Induced Cognitive Dysfunction By Restoring Microglia Homeostasis
… with a decreased expression of the postsynaptic protein PSD95, but no decrease in the presynaptic protein synaptophysin, in the hippocampus. I did not detect a significant decrease in mitochondrial function or morphology in brain synaptosomes, myelination in the cingulate cortex using …