Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 25 for “"synaptic connectivity"”.
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EGFR signaling regulates synaptic connectivity via Gurken
… or epilepsy. To identify novel regulators of synaptic development, I screened for mutants with defects in synaptic morphology and growth at the Drosophila larval neuromuscular junction: NMJ). My screen identified several mutants with defects in various aspects of synaptic development. I …
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Regulation of survival and synaptic connectivity in the adult brain by cell-intrinsic excitability
… activity is sufficient to effect alterations in synaptic connectivity with the surrounding circuit and that input connectivity is regulated in an activity-dependent manner by Npas4 signaling. Progress in the field of adult neurogenesis is beginning to shed light on the flexibility that adult-born …
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Identification of a Role for Huntingtin in the Control of Synaptic Connectivity in Circuits Disrupted by Huntington’s Disease
… has shown that there are alterations to the connectivity of patients’ brains preceding degeneration. This study focuses on how wild type Htt contributes to establishing and maintaining synaptic connectivity and how a loss of normal Htt function may contribute to the synaptic alterations in …
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MELANOPSIN AND PACAP IN INTRINSICALLY PHOTOSENSITIVE RETINAL GANGLION CELLS REGULATE THE DEVELOPMENT OF RETINOFUGAL PROJECTIONS IN MICE
… using Expansion Microscopy (ExM) to study synaptic connectivity of ipRGCs in the mouse retina. This strategy utilizes hydrogel chemistry to physically expand brain and retina samples, enabling nanoscale analysis of synaptic properties. I report an experimental approach for studying ipRGC …
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Experience-Dependent and Input-Specific Regulation of Neocortical Circuit Development by Genes Linked to Neurodevelopmental Disorders
Abnormal structural and functional brain connectivity has been widely observed in human neuropsychiatric diseases. Specifically, patients with neurodevelopmental disorders like autism often show an imbalance in the local versus long-range connectivity for cerebral cortex. Whether and how genes …
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Augmenting Wiring Diagrams of Neural Circuits with Activity in Larval Drosophila
… circuit elements of its nervous system. Synaptic wiring diagrams mapped from structural imaging of nervous systems guide modeling of neural circuits on the basis of connectivity. However, connectivity alone may not sufficiently constrain the set of plausible circuit hypotheses for …
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Identification and Characterization of Novel Mechanisms of Functional and Structural Synapse Remodeling: Focus on Vav Guanine Nucleotide Exchange Factors and MEF2 Transcription Factors
Proper development of synaptic connectivity is a dynamic process requiring formation, elimination, maintenance, and plasticity of synapses. During early postnatal development, excess synapses are formed in most neural circuits, which are subsequently pruned during adolescence in a sensory- and …
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Neuronal Polarization and Axonal mRNA Localization on Microfabricated Substrates
… of information via elaborate patterns of synaptic connectivity. Various arrangements of numerous growth factors, guidance cues, and other molecules influence both the interconnectivity of neurons and the subcellular makeup of individual neurons. This dissertation describes experiments that …
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Multifocal Multiphoton Microscopy for Neurobiological Imaging
… neuronal structures and monitoring changes in synaptic connectivity with respect to time have a significant impact on understanding the basis of structural brain abnormalities and the development of therapeutics for their correction. Today, multiphoton excitation fluorescence microscopy is the …
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Diverse Mechanisms Impair Thalamic Circuit Function in a Dravet Syndrome Mouse Model
… Here, we sought to identify the cellular and synaptic mechanisms underlying somatosensory CT circuit dysfunction in a haploinsufficiency DS mouse model. This work reveals that NaV1.1 haploinsufficiency leads to cell-type-specific changes in the excitability of reticular thalamic (nRT), ventral …
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Cellular and Synaptic Morphology of Golgi -Impregnated Cortical Neurons in Patients With Schizophrenia
… patients exhibit anatomical reductions in synaptic connectivity. Prefrontal regions have been implicated as a site of vulnerability to pathophysiological alterations, while evidence of anatomical disturbances in other cortical regions points to more distributed changes. Our studies …
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Machine Learning Methods for Brain Image Analysis
… compound interactions between complex synaptic networks inside the brain remain some of the most challenging problems in neuroscience. Lack or abundance of data, shortage of manpower along with heterogeneity of data following from various species all served as an added complexity to the …
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The Role of MEF2 Transcription Factors in Neocortical Circuit and Synapse Development In Vivo
… proliferation to maximize contacts with presynaptic partners. Synapses are dynamic structures subjected to an equilibrium of formation and elimination rates to preserve meaningful and prune superfluous synapses, respectively. A neuron receives heterogeneous inputs and must tightly regulate …
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Dopaminergic Modulation Shapes Sensorimotor Processing in the Drosophila Mushroom Body
… to the mushroom body in order to adjust synaptic connectivity between Kenyon cells, the neurons representing olfactory stimuli, and the mushroom body output neurons that ultimately influence behavior. However, we still lack a mechanistic understanding of how the dopaminergic neurons …
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Visualizing Synaptic Specificity with GRASP
… precision as it selects a unique ensemble of synaptic partners from a vast array of potential targets. Visualization of individual synapses in the central nervous system is difficult in some contexts and impossible in others, and the ability to rapidly monitor connectivity in living animals …
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Positional Coordinates for Spinal Sensory-Motor Connectivity
… functioning of the nervous system is that synaptic connections are formed and neural circuits are assembled with precision. Two major contributors to the establishment of selective synapse formation are thought to be the positional and molecular identities of neurons. In many instances, the …
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In vivo and in vitro approaches to characterising axon growth and metabolic alterations in Parkinson’s disease
… onset, midbrain dopaminergic cells lose their synaptic connectivity before dying. The preposition that dopaminergic axons degenerate initially and predominantly in PD offers new critical opportunities for the development of neuroprotective and restorative therapies. However, we know little …
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Ethanol exposure during synaptogenesis in a mouse model of fetal alcohol spectrum disorders: acute and long-term effects on gene expression and behaviour
… by the rapid formation and pruning of synaptic connectivity that correlates to brain development during the human third trimester. B6 pups were treated with a high dose (5 g/kg over 2 hours) of ethanol at postnatal day 4 (P4), P7, or on both days (P4+7). Mice were evaluated using a …
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Identification of novel target genes for the plasticity-related transcription factor Zif268
Activity based alterations in synaptic connectivity are thought to underlie the processes involved in learning and memory. Measurable changes in neuronal activation by long-term potentiation (LTP) are widely investigated as a possible cellular correlate of this phenomenon, as it can be induced …
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The Albino Mouse Visual System: How Perturbed Retinal Development Leads to Altered Binocular Projections
… gene expression important for axon guidance and synaptic connectivity. Zic2 is expressed in fewer RGCs in the albino retina, coincident with the decrease in the ipsilateral RGCs and indicating that cell subtype specification is altered in the VT retina of albino mice. This thesis further …
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