Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"synaptic complex"”.
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Maguk Scaffolds Organize A Key Synaptic Complex In Horizontal Cell Processes Contacting Photoreceptors
<p>Synaptic processes and plasticity of synapses are mediated by large suites of proteins. In most cases, many of these proteins are tethered together by synaptic scaffold proteins. Scaffold proteins have a large number and typically a variety of protein interaction domains that allow many …
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Role of Neuroligin in Synapse Formation and Autism
… synaptogenesis through formation of a trans-synaptic complex with presynaptic neurexins. Interaction of neuroligin 1 with neurexins is regulated by alternative splicing of both neuroligin 1 (at splice site B) and of neurexins (at splice site #4). Full-length neuroligin 1 that binds only beta …
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Single molecule fret study on the mechanism of RecA mediated strand exchange
… resolution to observe the encounter complex between the RecA filament and dsDNA, we present evidence in support of the “sliding model” wherein a RecA filament diffuses on a dsDNA track. Our results suggest that the sliding of the dsDNA relative to the RecA filament can explain the …
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Development of Novel Technologies to Investigate DNA Double-Strand Break Repair Uncovers a Role for the ATM Kinase in Error-Free NHEJ with Implications for Neurodegenerative Diseases
… primarily through the Ku80 DNA-PKcs long range synaptic complex. We utilized DSB-Prism to uncover a novel role for the ATM kinase in promoting EF-NHEJ repair at highly transcribed genes. We show that ATM promotes EF-NHEJ repair via two genetically distinct pathways independently of DNA-PKcs …
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ARFGEF mutations: A mechanism for breast-to-brain metastasis
… expresses neurotransmitter receptors and forms synaptic-like connections with neurons, contributing to tumour growth and survival. Exome sequencing of 26 breast-to-brain metastasis (BBM) cancers identified ARFGEF3 mutations in the BBM samples. This suggests that the absence of ARFGEF3 in breast …