Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 57 for “"synapse formation"”.
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Synapse Formation in the Zebrafish Lateral Line
… pre- and postsynaptic partners are matched for synapse formation. The zebrafish lateral line offers the opportunity for greater insight into this process. Hair cells in the lateral-line neuromast exist as two intermingled subpopulations, anteriorly and posteriorly polarized cells. Afferent …
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Mechanisms of Synapse Formation and Synaptic Plasticity
Synapses are the fundamental building blocks of the nervous system. Following target cell contact, they are formed through a process that requires the precise orchestration of both pre- and postsynaptic differentiation of synaptic machinery. However, the precise time course of synaptogenesis, and …
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Role of Neuroligin in Synapse Formation and Autism
Neuroligins mediate synaptogenesis through formation of a trans-synaptic complex with presynaptic neurexins. Interaction of neuroligin 1 with neurexins is regulated by alternative splicing of both neuroligin 1 (at splice site B) and of neurexins (at splice site #4). Full-length neuroligin 1 that …
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Axon Development and Synapse Formation in Olfactory Sensory Neurons
… model for the study of axonal growth and synapse formation. The present set of studies attempts to provide insights into synapse formation and axonal development of olfactory sensory neurons. First, I sought to understand the regulation of expression of pre-synaptic molecules in the …
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Mechanisms underlying retinogeniculate synapse formation in mouse visual thalamus
Retinogeniculate (RG) synapses connect retinal ganglion cells to the thalamic relay cells of the dorsal lateral geniculate nucleus (dLGN). They are critical for regulating the flow of visual information from retina to primary visual cortex (V1). RG synapses in dLGN are uniquely larger and stronger …
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Regulation of filopodia dynamics is critical for proper synapse formation
… CNS, the molecular mechanisms that regulate the formation and development of synapses remain poorly understood. Indeed, the mechanisms through which initial synaptic contacts are established and modified during synaptogenesis have not been fully determined and a precise understanding of these …
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Modeling Synapse Formation and Growth as a Non-Biological Analog to the Brain
… a preliminary nondimensionalized model of synapses, an essential component for developing brain-inspired computing systems. The model simulates a physical analog of synapse formation wherein a single two-nanowire junction in an electrolytic medium undergoes an electric potential, causing …
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Opposing Actin Networks Modulate the Mechano-Activation of the Integrin LFA-1 During Immunological Synapse formation
Formation of a functional immune response requires the regulated transfer of information between T cells, and APCs, which leads to a variety of functional outcomes. In many cases this information transfer occurs at a regulated area of cell - cell contact termed the immunological synapse (IS). In T …
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The neural cell adhesion molecule 2 (NCAM2) promotes excitatory synapse formation through increasing insulin and insulin-like growth factor 1 receptor signaling
… disability. NCAM2 is enriched at excitatory synapses and is involved in synapse maturation and maintenance. The role of NCAM2 in the regulation of synaptogenesis, however, remains poorly understood. We hypothesized that NCAM2 promotes synaptogenesis through regulating insulin and IGF1 …
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Identification of a Role for Huntingtin in the Control of Synaptic Connectivity in Circuits Disrupted by Huntington’s Disease
… study, I examined the role of wild type Htt in synapse formation and maturation synapses in the basal ganglia circuit, and I examined how loss of wild type Htt function may affect the pathogenesis of HD. To do so, I created conditional deletions of Htt in the mouse brain by crossing a floxed …
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BDNF and Astrocyte TrkB.T1 Signaling as a Mechanism Underlying Astrocyte Synapse Interactions in Motor and Barrel Cortex
Synapses are the fundamental units of communication in the brain, and their proper development and function are critical for cognitive processes and behavior. While the development of glutamatergic synapses has been extensively studied, the mechanisms underlying the formation of the tripartite …
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The role of the cold shock protein, RBM3, in cooling, synaptic structural plasticity and neuroprotection
… misfolded proteins and the progressive loss of synapses, leading eventually to neuronal demise. Synapse loss occurs early in disease and is a reversible process: the pruning and regeneration of synapses, known as structural plasticity, is a continuous process in the brain and represents an …
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Ultramorphological Study of Synaptic Activity and Efficacy Change in the Perifused Rat Hippocampal Slice
… were increases in numbers of shaft and nubbin synapses, suggesting an increase in the number of shaft synapses onto inhibitory interneurons and/or an enhancement of synapse formation through a transition of shaft, to nubbin, to full grown spine synapses. Postsynaptic spines also changed to a …
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Developmental Dynamics of 5-Hydroxymethylcytosine and its Role in the Terminal Differentiation of Neurons
… is essential for the regulation of migration, synapse formation and terminal differentiation. Although 5-hydroxymethylcytosine (5hmC), the oxidized form of 5-methylcytosine, accumulates to high levels in neuronal lineages and refines the genomic binding of MeCP2, the functional consequences of …
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The Impact of pH on the Structure and Function of Neural Cadherin
… including tissue morphogenesis, excitatory synapse formation and dynamics, and metastasis of cancer. During neurotransmission and tumorigenesis, fluctuations in extracellular pH occur, causing tissue acidosis with associated physiological consequences. Studies reported here aim to determine …
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Functional genomic and transcriptomic tools for spatial and dynamic phenotypes
… modulators of excitatory and inhibitory synapse formation, implicating diverse cellular pathways in this process. To increase the throughput of these optical pooled screens, we also built a fluidics platform for automated in situ sequencing. Finally, we leveraged retroviral polyproteins …
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The effects of anaesthetic agents on synapses of lymnaea stagnalis (L.)
… follower cells VD2/3 (unidirectional excitatory synapse) and VD4 (mutual inhibitory synapse). This suggests that these neurons are not themselves GABAergic, although this investigation shows the responses of these neurons to bath and direct application of GABA. Na-thiopentone did not reliably …
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RNA Localization and Translational Regulation on the Endoplasmic Reticulum
… embryogenesis, cell fate specification, and synapse formation. Signal sequence-encoding mRNAs are localized to the endoplasmic reticulum (ER) membrane by either of two mechanisms, a canonical mechanism of translation on ER-bound ribosomes (signal recognition particle pathway), or a poorly …
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Neuromuscular Synaptic Proteins In Development And Regeneration
… peripheral nerve development and neuromuscular synapse formation are mostly understood, it is unclear whether the same pathways are reemployed to promote regeneration. For example, neuromuscular synapses form through the Agrin-Lrp4-MuSK signaling pathway that clusters acetylcholine receptors …
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Control of Neuronal Circuit Assembly by Gtpase Regulators
… arises from a series of morphological transformations: neuronal differentiation, migration, axonal guidance, axonal and dendritic arbor growth and, eventually, synapse formation. Changes in neuronal morphology are driven by cell intrinsic programs and by instructive signals from the …
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