Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"synapse development"”.
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Eye-opening and control of visual synapse development in the mouse superior colliculus
… a high resolution map of visual space early in development, before eye-opening in rodents (-P12-P14). The cortical projection is delayed by about eight days, just reaching the sSC around P4, and does not complete its topographic refinement until around the time of eye-opening. These afferents …
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The Role of MEF2 Transcription Factors in Neocortical Circuit and Synapse Development In Vivo
Proper neocortical circuit development requires postnatal experience and transcription. Neocortical neurons migrate to their proper layers and then undergo robust synapse proliferation to maximize contacts with presynaptic partners. Synapses are dynamic structures subjected to an equilibrium of …
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Regulation of mammalian neuronal circuit development by CPG 15
… assembly of neuronal circuits is specified by developmental programs of gene expression, however, the final stage in circuit development, maturation and refinement of specific synaptic connections, is strongly influenced by neuronal activity. It is thus not surprising that the products of many …
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Role of Neuroligin in Synapse Formation and Autism
… binds only beta -neurexin more potently promotes synapse formation in hippocampal neurons, whereas neuroligin 1 lacking splice site B, which binds both alpha - and beta -neurexins, is more efficient at synapse expansion. Mutations in two surface loops of neuroligin 1 abolished neuroligin binding …
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Neuromuscular Synaptic Proteins In Development And Regeneration
… reestablish neuromuscular connections with their developmental targets. While the molecular pathways that govern peripheral nerve development and neuromuscular synapse formation are mostly understood, it is unclear whether the same pathways are reemployed to promote regeneration. For example, …
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Genomic studies of motif enrichment and conservation in the regulation of gene expression in the brain
… of whose members are known to play a role in synapse development. Data from chromatin immunoprecipitation and tiling-microarray (ChIP-on-chip) experiments [11 have isolated peaks of specific binding by MEF2 in developing rat brains. Conservation and enrichment of these sites are analyzed here …
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BDNF and Astrocyte TrkB.T1 Signaling as a Mechanism Underlying Astrocyte Synapse Interactions in Motor and Barrel Cortex
Synapses are the fundamental units of communication in the brain, and their proper development and function are critical for cognitive processes and behavior. While the development of glutamatergic synapses has been extensively studied, the mechanisms underlying the formation of the tripartite …
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Molecular mechanisms of synaptic proteins
… molecules (SAMs) are critical for regulating synapse development and synaptic plasticity. Many studies have linked their putative roles in neuropsychiatric and neurodevelopmental diseases, such as schizophrenia and autism spectrum disorder. Here, the structure-function relationships of a …
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Molecular mechanisms of synaptic proteins
… molecules (SAMs) are critical for regulating synapse development and synaptic plasticity. Many studies have linked their putative roles in neuropsychiatric and neurodevelopmental diseases, such as schizophrenia and autism spectrum disorder. Here, the structure-function relationships of a …
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The Effects of Ethynodiol Diacetate on Epinephrine-Treated Glial-Derived Cells
… the central nervous system that play roles in synapse development, blood flow regulation, extracellular homeostasis, synapse function, energy and metabolism (Sofroniew and Vinters, 2009). Research using astrocytes in cell viability studies can be beneficial in deepening our understanding of …
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Biophysical and Structural Studies of CNTNAP2
At synapses, cell adhesion molecules provide connection between the presynaptic and postsynaptic membranes through homophilic and heterophilic interactions promoting synapse development, function, and plasticity. The synaptic adhesion molecules contactin 2 (CNTN2), and contactin associated …
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A genetic screen for genes involved in dendrite morphogenesis of central neurons in Drosophila melanogaster
… regions required for motor neuron dendrite development. Specifically, the Mosaic Analysis with a Repressible Cell Marker (MARCM) method was modified so that individual motor neurons can be made homozygous for a defined genomic aberration in an otherwise wild-type (heterozygous) background …
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Regulation of Presynaptic Ca²⁺ Channel Abundance at Active Zones Through a Balance of Delivery and Turnover
… BRP levels continue to increase given extended developmental time. AZ Cac is also buffered against moderate increases or decreases in biosynthesis, whereas BRP lacks this buffering. To probe mechanisms that determine AZ Cac abundance, intravital FRAP and Cac photoconversion were used to …
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Unravelling the molecular mechanisms of HIV associated neurocognitive disorders through mass spectrometry-based proteomics
… injury - as the cytoskeleton is crucial for synapse development and maintenance - and may contribute to memory impairment in HIV associated neurocognitive disorder patients.
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Linking WRP/srGAP3 to the Cognitive Deficits in 3p- Syndrome and Its Role in the Regulation of Dendritic Filopodia Formation
… GAP (WRP) is thought to regulate key aspects of synapse development and function, and has been implicated in a form of mental retardation in humans called 3p- Syndrome. WRP is a member of the srGAP family of Rho GAP domain containing proteins, which share a characteristic domain organization and …
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Mechanism and Function of TrkB.T1 Astrocyte Expression
… expression and the role of TrkB.T1 in astrocyte developmental process are unknown. In this dissertation, we aimed to determine in the DNA methylation contributes to isoform specific expression of TrkB.T1. We thus profiled the 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) in neurons, …