Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"swarming motility"”.
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Chimera Ligand for Pili and Lectin A Protein Controls Antibiotic-Promoted Biofilm Formation, Swarming Motility, Tolerance and Persister Formation by Pseudomonas aeruginosa
… of Pseudomonas aeruginosa to inhibit both swarming motility and biofilm formation. The potential adjuvant agents of these chimera ligands that can increase the effectiveness of antibiotics were demonstrated. In addition, the ability of our adjuvant molecules to eliminate drug-tolerant …
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Discovering the Biological Activities of Maltose Derivatives for Controlling Bacterial Multicellular Behaviors
… behaviors, like biofilm formation and swarming motility, which are not essential for bacterial survival but are critical for infections. Consequently, the use of such nonmicrobicidal agents is less likely to induce evolution of bacterial genes. The use of two different kinds of …
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Characterization of major virulence regulators of Erwinia amylovora
… mutants of envZ/ompR and grrA/grrS have opposite swarming motility phenotypes. In order to determine how the two systems interact, two triple mutants, envZ/ompR/grrA (ERA) and envZ/ompR/grrS (ERS) were generated. Our results showed that both triple mutants had slightly increased virulence on apple …
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Identification of novel regulators of the necrosis-inducing protein (Nip) and carbapenem antibiotic production in the phytopathogen Pectobacterium
… enzymes (PCWDEs) and is capable of swimming and swarming motility. Some strains also produce a simple β-lactam carbapenem antibiotic, 1-carbapen-2-em-3-carboxylic acid. This carbapenem cluster is cryptic in several strains of Pectobacterium but can be activated by introduction of its cognate …
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Novel pleiotropic regulators of flotation, secondary metabolite production, and virulence in Serratia sp. ATCC 39006
… is capable of flagellar-mediated swimming and swarming motility. S39006 is the only enterobacterium known to naturally produce gas vesicles (GVs). GVs are proteinaceous, intracellular organelles that increase the buoyancy of a cell and enable flotation upwards through the water column and …
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Investigating the role of Leucine-Responsive Regulatory Protein (Lrp) in the production and regulation of specific virulence factors in Pseudomonas aeruginosa
… in regulating other important systems such as swarming motility and biofilm formation. In nutrient limited environments, Lrp may regulate an estimated 4-14% of the genome. </p>
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Controlling Microbial Multicellular Behaviors With Saccharide Derivatives
… behaviors like biofilm formation and swarming motility are known to increase their tolerance against antimicrobials. From microbial standpoint, nonmicrobicidal agents that do not impede growth are tolerable and therefore, there is a lower propensity to develop resistance against such …
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An individual-based GPU simulation framework for collective bacterial dynamics in swarms and biofilms
… mechanical cell-cell interactions dominate the swarming motility phases and can account for the emergence of order and structure seen in growing biofilms. Furthermore, this model is used to explore the effectiveness of surface topography on deterring biofilm formation by investigating how …
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Natural and Synthetic Ligand-Binding Induce Different Pilin Assemblies in vitro and Control P. aeruginosa Bioactivities in vivo, and Development of Bacterial-Motility Enabled Binding Assays
… this function.</p> <p>Using a novel bacterial motility-enabled binding assay, we demonstrated that spreading expressed pilin monomers on the hydrated gel surface can inhibit the swarming motilities of the wild-type P. aeruginosa by binding and sequestering rhamnolipids secreted by the …
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Understanding protease-mediated host-pathogen interactions in <i style="">Proteus mirabilis</i>
… monomers; this may be particularly useful during swarming motility, in which <i>P. mirabilis</i> cells become hyperflagellated, to avoid Toll-like receptor 5 (TLR5)-mediated recognition. The <i>N</i>-alpha mercaptoamide dipeptide inhibitor, ME-YV, was included in these experiments and shown to …
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New Pleiotropic Co-Regulators of Gas Vesicle and Secondary Metabolite Production in Serratia sp. ATCC39006
… production, but showed increased swimming and swarming motility. Additionally, a siderophore, cellulase and plant virulence were reduced in the mutant. In the topA mutant, prodigiosin was greatly elevated but reduction was observed in carbapenem, cellulase, pectate lyase, N-BHL and siderophore …
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Analysis of Vibrio parahaemolyticus Virulence Systems
… in biofilm growth, but shared similar levels of swarming motility and effector production/secretion. Additionally, while the cytotoxicity of these strains was similar, the CAB2 (T3SS1 regulatory mutant) strain was strikingly more invasive than the comparable POR2 (T3SS1 structural mutant) strain. …
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Evidence of Water to Human Transmission of Aeromonas Hydrophila: Critical Role of Quorum Sensing in Bacterial Virulence & Host Response
… model of infection, had diminished swimming and swarming motility, and the mutant bacteria formed denser biofilms when compared to the parental strain of A. hydrophila. The decrease in the virulence of A. hydrophila ∆qseB mutant correlated with reduced production of protease and the cytotoxic …
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N-acylhomoserine lactone regulation of adhesion and biofilm differentiation in Serratia marcescens MG1
… utilises a regulatory system for regulation of swarming motility and exo-enzyme secretion that relies on the production of a diffusible signal identified as N-butanoyl-L-homoserine lactone (C4-HSL). The aim of this study was to determine the role of C4-HSL in surface colonisation (adhesion and …
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Regulation of amylovoran biosynthesis in Erwinia amylovora
… phenotypes such as exopolysaccharide production, swarming motility and bacterial virulence. Orphan genes (ORFans) are annotated genes that exclusively exist in a particular genome, strain, species or lineage. One of the enterobacteria-specific orphan genes is annotated as ybjN gene. So far, our …
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Rational Development of Small Molecules Targeting Virulence of Pseudomonas aeruginosa
… project are the type III secretion system and swarming motility. During this project rational $\textit{in silico}$ drug discovery methods were used to identify small molecule inhibitors of ExsA, the master transcriptional regulator of the type III secretion system. The molecules were ordered …
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Identifying Pantoea Genetic Factors Involved in Host Association by Integrating Comparative Genomics with a Dictyostelium discoideum Grazing Resistance Model
… BRT175, was identified as being key for both swarming motility and grazing resistance. However, the rhlA and rhlB genes were present in both grazing-resistant and -susceptible strains. Chapter 3 addresses the differential regulation of rhlA in Pantoea. Variants within the putative promoter …
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The interplay between pathogenic bacteria and bacteriophage Chi: New directions in motility and phage-host interactions in Enterobacterales
… bacteria through their surroundings via swimming motility, or on surfaces via swarming motility. The flagellum is a key virulence factor for motile pathogenic bacteria. Viruses that infect bacteria via this appendage are known as flagellotropic or flagellum-dependent bacteriophages. Much like …
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A New Class of Antibiotic That Prevents Drug Tolerance, Persistence, and Resistance By Controlling Emergence of Phenotypes.
… a new label-free assay based on bacterial motility sensing the environment, chemical inhibition of bacteriophage adsorption on pili appendages of bacteria, and fluorescence polarization. Structure-activity relationship studies reveal a molecule that inhibits only pili appendage, and a class …
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Novel pleiotropic regulators of gas vesicle biogenesis in Serratia
… (car) and prodigiosin. It displays different motility mechanisms, such as swimming and swarming aided by flagellar rotation and biosurfactant production. In addition, S39006 produces gas vesicles to float in aqueous environments and enable colonization of air-liquid interfaces. Gas vesicles …