Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 157 for “"sustained release"”.
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Sustained-release implants for intraperitoneal cisplatin delivery
The objective of this work was to develop materials for continuous low-dose delivery of cisplatin directly into the abdomen, also known as intraperitoneal (IP) chemotherapy. IP chemotherapy can help treat peritoneal metastasis in many advanced gynecologic and gastrointestinal cancers and has shown …
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Novel sustained release formulation of leveodopa-dendrimer conjugate
… way to solve these problems was to deliver a sustained amount of levodopa to the brain so that a constant level of dopamine is maintained at the dopamine receptor sites. Therefore, in this study a novel sustained release formulation of levodopa was prepared which efficacy was evaluated by …
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In vitro Sustained Release Delivery System for Hydrogen Sulfide Analogs
… they are inside our body but they must do so at sustained rate to prevent any adverse effect including toxicity. However, developing a sustained release delivery system of a H2S donor is a great challenge due to instantaneous release of H2S when they come into contact with water. The best way to …
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Biodegradable polymers for the sustained release of antisense nucleic acids
… may be improved by employing a sustained release delivery system which would protect from degradation by nucleases whilst delivering the nucleic acid in a controlled manner to the site of action. Biodegradable polymer films and micro spheres were evaluated as delivery devices for …
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Development of solid lipid nanoparticles for sustained release of anticancer agents
… has many advantageous such as controlled drug release, non-biotoxicity of the carrier, increased bioavailability of drug and lower overall cost. Techniques for the production of SLN, drug incorporation, loading capacity and drug release mechanisms are reviewed. The potential of SLN in …
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Development of Co-processed Plasticized Cellulose Acetate for Sustained Release Matrix Tablets
… of CA, it is a good polymer candidate for sustained release matrix tablets. Sustained release matrix tablets of cellulose acetate can be prepared by direct compression or wet granulation methods. However, previous studies showed that a large amount of CA was required to achieve the desired …
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Development of Multiple Microemulsion Eye Drops for Sustained Release of New Glaucoma Drug
<p>Persistent or repeated elevation of intraocular pressure (IOP) is a primary risk factor of visual field loss in glaucoma, therefore IOP reduction is the first-line therapeutic option in the disease management. Unfortunately, the current therapies are associated with a lot of deficiencies …
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Development and Characterization of Sustained-Release Formulations via Novel Hot Melt Extrusion Techniques
… process) for preparing an improved controlled/sustained release formulation is the main theme of this research project. Current research focusing on Active Pharmaceutical Ingredients (APIs) with good aqueous solubility requires novel approach to obtain tailored drug release for the processed …
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Novel Transporter Targeted Lipid Ester Prodrugs of Cidofovir and Sustained Release Formulations for Cytomegalovirus Infection
… prodrug candidate for future in vivo evaluation. Sustained release (~3 weeks) formulation of B-C12-cCDF loaded PLGA nanoparticles may serve as a viable intravitreal delivery approach for the treatment of CMV retinitis. Based on the above finding we hypothesized that lipid raft facilitates enhanced …
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Diethylstilbestrol Nanosuspensions for Prostate Cancer: Subcutaneous Sustained Release Formulations and Pre-clinical PK/PD Evaluations
… Thus, our aim was to develop a subcutaneous sustained release nanosuspension formulation of DES, which would circumvent the first pass effect of DES, potentially reducing the thromboembolic and cardiovascular complications and maintaining or improving the efficacy of DES by sustaining its …
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Effects of a sustained-release copper bolus on growth and reproductive traits of beef bulls
… were conducted to determine the effects of sustained -release copper (Cu) boluses on growth and reproductive traits of beef bulls. Two groups of bulls were used in consecutive years (n=26 in experiment 1; n=20in experiment 2). Bulls in each experiment were allotted by weight and breed into …
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Sustained Release of Growth Factors from Hyaluronic Acid Hydrogels and Polyethylene-Glycol Microparticles for Axonal Growth
… (PEG-DA) microparticles as platforms for sustained delivery of bioactive NT-3 and IGF-1, respectively. HA hydrogels were successfully synthesized using a polyethylene-glycol (PEG) dimaleimide crosslinker and characterized chemically and mechanically. The stiffness of the hydrogels was …
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Design and development of drug delivery systems for immediate and sustained release utilizing hot melt extrusion
… is a critical factor to obtain the desired drug-release profile during formulation development for HME (Hot melt extrusion). Many commercially available, pharmaceutical-grade polymers can be used in HME formulations. The suitable polymer choice facilitates processing in the extruder. When …
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Immediate release ginseng chewable tablets and sustained release amino acid pellets based on dry powder coating technology platform
… platform, this study aimed to develop immediate release ginseng chewable tablets using the electrostatic powder coating technique and sustained release amino acid pellets using the plasticizer powder coating technique. For the immediate release ginseng chewable tablets, the content and types of …
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The suitability of biodegradable poly(dl-lactide-co-glycolide)75:25 microspheres for the sustained release of antibiotics
… vancomycin, ciprofloxacin and rifampicin within sustained release microspheres composed of the biodegradable polymer poly (dl-lactide-co-glycolide) [PLCG] 75:25. Topical administration to the wound in hydroxypropylmethylcellulose gel should achieve high local antibiotic concentrations while the …
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Effects Of Sustained Release Somatostatin Type 2 Antagonism On Glucagon Counterregulation And Glycemia In Type 2 Diabetic Rate Model
… though the effects were small. Overall, sustained exposure to SSTR2a modestly improved the glucose and glucagon response to insulin-induced hypoglycemia in this T2D model, suggesting the potential for this approach to prevent hypoglycemia in insulin-requiring T2D.
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Modeling the sustained release of PLGA-based drug delivery systems with a physically-based model and pore space characterization
Sustained release systems have demonstrated benefits in the field of drug delivery owing to their improved therapeutic efficacy, high patient compliance, bioactivity, and biocompatibility. With a number of physico-chemical processes in effect, well-controlled long-term release behavior from these …
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Preparation, Characterization and Toxicity Evaluation of a Novel Sustained Release Delivery System for a Hydrogen Sulfide Donor - GYY 4137
… in water. Thus, a search for a hydrophobic, sustained release delivery system for H2S donors is warranted in order to harness its therapeutic potential. This study investigated the preparation and characterization of a non-aqueous in situ gelling sustained release delivery system for H2S …
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