Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"survival in macrophages"”.
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The Thiol Specific Antioxidant (TSA1) Gene is Required for Survival in Macrophages and Oxidative Stress Resistance in Histoplasma Capsulatum
… fungus that causes one of the most common invasive fungal respiratory diseases, Histoplasmosis. <em>Histoplasma</em>undergoes a dimorphic shift from mold to yeast which is crucial to pathogenesis of the organism.</p> <p>The thiol specific antioxidant gene, <em>Tsa1,</em>is strongly …
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Studies on oligopeptidase B of Leishmania major
… hypothesised that peptidases are crucial for the survival of Leishmania in its hosts and that many could be potential targets for new antileishmanial drugs. As such, the investigation of peptidase activity in live Leishmania promastigotes was proposed as a valuable approach by which to increase …
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Pleiotropic regulatory function of the lysr family transcriptional regulator cpsy during streptococcus iniae systemic infection
… for optimal expression of virulence determinants is a continued area of research. Orthologs of the <i>Streptococcus iniae</i> LysR family regulator CpsY have been shown to regulate methionine biosynthesis and uptake pathways, but appear to influence expression of several virulence genes as …
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Regulation of virulence in Salmonella enterica
… enterica serovar Typhimurium is a facultative intracellular pathogen, capable of causing disease in a variety of animal hosts. Both invasion of the host intestinal epithelial cells, and survival and replication in host macrophages are required for the successful establishment of the …
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The Role of Urease in the Pathogenesis of Edwardsiella ictaluri
An Edwardsiella ictaluri strain with disruption of ureG was identified through the use of signature tagged insertion mutagenesis as being attenuated for virulence in the channel catfish host. Sequencing of the flanking regions surrounding the insert showed that the gene was part of a urease gene …
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Proteomics of physiologically relevant stresses on model mycobacterium tuberculosis organisms, and the effects on virulence
In 2020 approximately 10 million people suffered from tuberculosis and it is estimated that 1.5 million died. Mycobacterium tuberculosis which is the causative agent of tuberculosis disease, is an obligate aerobic bacterium with a unique cell wall and is capable of surviving and infecting a …
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Population genetic frameworks and functional genomics of Mycobacterium bovis
Bovine tuberculosis is a zoonotic infection of cattle caused by Mycobacterium bovis. Approximately one-third of the world's population is infected with M. tuberculosis or M. bovis, "the world's most successful pathogen", the majority in developing countries. The global spread and increasing …