Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"survival factors"”.
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The exploitation of neuronal survival factors in Burkitt’s lymphoma and germinal centre B cells
… within neuronal networks for development and survival. Based on previous evidence revealing the expression of neurotrophin components in immune cells, the present study investigates neurotrophin component expression within Burkitt’s Lymphoma B cells. Different latency stages within Burkitt’s …
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Common Signaling Elements in Response Pathways Activated by the Endothelial Survival Factors VEGF and Insulin
… factor (VEGF), an endothelial cell mitogen/survival factor, and insulin, which has anti-apoptotic effects on endothelial cells in addition to regulating glucose homeostasis. Insulin and VEGF, upon activating their respective tyrosine kinase receptors, can engage the PI3-kinase/Akt, MAPK, and …
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Biological Mechanisms and Clinical Implications of Bcr-Abl-Induced Mitochondrial Oxidative Stress and Cell Survival In Chronic Myeloid Leukemia
… biological alterations contribute to CML cell survival and drug refractory. Mitochondria and NAD(P)H oxidase (NOX) are the major sources of BCR-ABL-induced cellular reactive oxygen species (ROS) production. However, it is still unknown how CML cells maintain the altered redox status, while …
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La influencia de la tecnología de la vinificación en la microbiología y el desarrollo de la fermentación alcohólica
… (by oxygen addition direct and racking), Survival factors addition (Ergosterol), Yeast hulls addition and inert cellulose substrates addition (tree celluloses with different physical characteristics). The more relevant results showed the influence of the type of grape juice clarification …
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Avaliação dos processos de gestão do conhecimento e inovação no setor de serviços: desenvolvimento de modelo e estudo de caso
… management and innovation are recognized as survival factors for enterprises, and criteria for their evaluation allow managers to act in a more effective manner to their improvement. From the identification of several aspects related to knowledge management and innovation, as well as other …
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Factors affecting breast, cervical and prostate cancer treatment outcomes in Zambia
… patient socio-demographic characteristics and survival factors using the Zambia National Cancer Registry (ZNCR) data collected during January 1st 2008 - December 31st 2015. We conducted secondary ZNCR data incidence and mortality analyses of by province for these cancers. Data were cleaned …
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Factors affecting breast, cervical and prostate cancer treatment outcomes in Zambia
… patient socio-demographic characteristics and survival factors using the Zambia National Cancer Registry (ZNCR) data collected during January 1st 2008 - December 31st 2015. We conducted secondary ZNCR data incidence and mortality analyses of by province for these cancers. Data were cleaned …
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rd1 Photoreceptor Degeneration: Photoreceptor Rescue and Role of Metalloproteases in Retinal Degeneration
… left. In order to study the effect of factors which delay or halt the photoreceptor degeneration, a long term retina organ culture has been used. The culture medium of this culture paradigm was devoid of fetal calf serum (FCS) as FCS by itself contains an unknown number of growth …
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Characterization of human IgA-inducing protein
… cell trafficking to the lymph nodes. DC-produced survival factors such as BAFF and APRIL have been shown to be essential for B cell maturation, but have also been implicated in class-switch recombination and B cell lymphoma survival. Recently added to this list of DC-derived factors effecting B …
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Discovery of the First Endogenous Gain of Function Mutation in Drosophila RAS1 as a Dominant Suppressor of Apoptosis
… and number. According to the trophic theory of survival, this is achieved in part by a competition between cells in a tissue for a limited number of extracellular survival factors. Cells that do not receive sufficient quantities of these survival cues engage a default cell death program and are …
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Radiosensitization of Head & Neck Carcinoma Cells by Linifanib, A Receptor Tyrosine Kinase Inhibitor
… cell carcinomas (HNSCC) express angiogenic factors such as vascular endothelial growth factor (VEGF). Since radiotherapy is one of the most commonly used treatments for HNSCC, it is imperative to identify the interactions between antiangiogenic therapy and radiotherapy, and to develop …
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Cell-cell and cell-medium interactions in the growth of mouse embryonic stem cells
… has been great interest in the identification of factors that govern the differentiation of ESCs into specific lineages. Much of this research builds on previous studies of the role of intercellular signaling in the specification of various cell types in the developing embryo. However, relatively …
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BAD and Mcl-1 Regulation in Prostate Cancer
… of BAD as the convergence point for several survival signaling pathways including the PKA, EGF, and PI3K/Akt pathways in prostate cancer cells. Upon phosphorylation of these residues, BAD becomes unable to bind to and inactivate the anti-apoptotic Bcl-2 subfamily, including Bcl-2 and Bcl-xL, …
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Mitochondrial Instability, Lack of Erk1/2 Activation and High Expression of P75NTR in Engrailed-Deficient Mesencephalic Dopaminergic Neurons
… Prakinson’s Disease. The homeobox transcription factors, Engrailed-1 and Engrailed-2, are essential for survival and long-term maintenance of this neuronal population. In mutant embryos, null for both genes, the mesDA neurons are generated and start to express their neurotransmitter phenotype, …
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Human Cytomegalovirus and the Neutrophil
… In this context, enhanced neutrophil survival may promote infection. This work describes a profound neutrophil survival phenotype elicited by contact with live or UV-inactivated HCMV, in the absence of lytic viral gene expression. The effect does not involve signalling through …
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Amyotrophic Lateral Sclerosis: mechanism behind mutant SOD toxicity and improving current therapeutic strategies
… death. The relevance of Hsp90 for motor neuron survival was investigated in mutant Cu/Zn superoxide dismutase (SOD) transgenic animal models for ALS. Nitrated Hsp90, a posttranslational modification known to induce cell death (Franco, Ye et al. 2013), was present in motor neurons after …
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Immunomodulation in Adenovirus-Induced Viral Hepatitis
… infection, two molecules that favor hepatocyte survival by up-regulating bcl-2 gene, which have also immune regulatory functions. Here, we asked whether these pro-survival and regulatory molecules could influence outcomes in virally induced hepatitis. By using an animal model of adenovirus …
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Study of prognostic markers in advanced cancer
… informal and subjective. Clinicians base survival predictions upon clinical experience, clinical intuition and knowledge of cancer trajectories. Prognostic factors have been identified and validated in patients with cancer. These can be clinical markers or biomarkers. Clinical markers …