Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"surrogate measures"”.
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Trajectory features as surrogate measures of the nanoparticle-microenvironment interaction space
The use of nanoparticle platforms in the field of medicine as diagnostic tools and therapeutic agents has been a long-promised hope. Despite some successes, including FDA approval of micelle and liposomal formulations for the delivery of strongly hydrophobic anticancer drugs, the translation of …
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A comparative evaluation of surrogate measures of adiposity as indictors of cardiometabolic disease
… In particular, it aimed to determine how useful surrogate measures of adiposity might be to identify high-risk patients within a clinical setting. Using a cross-sectional sample of 2,047 middle-aged men and women, the main objectives were: (1) to examine the rationale for adiposity assessment …
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DISCREPANCY MEASURES OF ROLE PERCEPTIONS AS SURROGATE MEASURES OF OCCUPATIONAL ROLE STRESS: A THEORETICAL AND CONCEPTUAL ISSUE
Discrepancy or difference measures of job-related role perceptions have long been employed as environmentally-based surrogate measures of occupational role stress (i.e., subjective role conflict and role ambiguity). The validity of these differences measures as alternate indices of role stess, …
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Theory and Algorithms for Penalization, Graphical Models, and Surrogate Marker Evaluation
… statistics theory, graphical models, and surrogate measures in clinical trials. First, we introduce a general slow rate bound for maximum regularized likelihood estimators in Kullback-Leibler divergence. The result applies to a wide variety of models and estimators where the densities have …
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Changes in the characteristics of approved New Drug Applications for antihypertensives
… preliminary analysis of a number of quantitative surrogate measures of complexity and scale, such as trial design, numbers of patients, treatment lengths, active drug comparators, number of indications pursued, number of indications approved, and approval times. In addition, I review how practice …
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An Application of Bluetooth Technology to Rural Freeway Speed Data Collection
… zones using travel times and travel speeds as surrogate measures of congestion, and to test the feasibility of using fewer nodes to cover large distances in urban areas.
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EFFECTS OF ANTHROPOGENIC SELECTION PRESSURE ON THE EVOLUTION OF A COMMON AGRICULTURAL WEED: DOES ADAPTATION COME WITH A DETECTABLE COST? A STUDY OF GLYPHOSATE-RESISTANT (GR) AND -SUSCEPTIBLE (GS) BIOTYPES OF Conyza canadensis
… to measure, other variables may be used as surrogate measures of fitness, such as reproduction, growth rate, phenology, survivorship, etc. This research seeks to determine if differences exist in surrogate measures of fitness - patterns of growth, reproductive allocation, and competitive …
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Assessment of case-based integrated learning as a part of dental curriculum reform
… chosen for the quantitative portion were surrogate measures of National Board Scores and grade point averages to represent knowledge and skills. The overall analysis of the quantitative data shows negligible impact on the outcomes being measured. We know from the literature that active …
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Biomechanical adaptations of lower-limb amputee-gait: Effects of the echelon hydraulically damped foot. Segmental kinetic and kinematic responses to hydraulically damped prosthetic ankle-foot components in unilateral, trans-tibial amputees.
… device ‘performance’ can be evaluated using surrogate measures and without modelling an ‘ankle joint’ on the prosthetic limb.
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Pedestrian Safety and Level of Service at Uncontrolled Crosswalks - Advanced Data to Enhance Evaluations
… As agencies increasingly rely on behavioral and surrogate measures to diagnose risk, the need for reliable, continuous pedestrian-vehicle movement data becomes critical. This dissertation develops a unified methodology structured around two major components. The first component introduces a …
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Information system success and its association with user attitude, belief and involvement
… research was twofold. The first was to explore measures of information system success. The second, to investigate the influence of user variables, specifically attitude, belief and levels of user involvement, on information system success. Although researchers agree that the aggregate …
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Microbial diversity of a nature reserve: eukaryotic microorganisms of Mere Sands Wood in N.W. England
… richness highlighted the potential for using surrogate measures for future rapid biodiversity surveys.The use of evolutionary life strategies in protists is an area for future study which may provide useful insights into nature conservation management for microscopic organisms in habitats …
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Clinical Translation of Optoacoustic Imaging in Breast Cancer
… In turn, these signals can be regarded as surrogate measures of tissue hypoxia and neoangiogenesis, hallmarks of cancer associated with adverse outcomes. The aim of this PhD was to translate optoacoustic imaging into the breast clinic to try and fulfil some of the unmet clinical needs in …
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3D Object Detection for Road Safety at Urban Intersections
… times necessitate a proactive approach using surrogate measures of safety to address risks preemptively. This thesis delves into improving the accuracy of automatic measurements of surrogate safety indicators (SSI), adapting state-of-the-art computer vision techniques for surrogate safety …
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Operating ratios and institutional characteristics affecting the responsiveness of black colleges and universities to professional allied health programs
… these ratios and characteristics were direct or surrogate measures of institutional adaptation. The following analytical procedures were used: (a) cross-tabulation, (b) t-tests for independence, (c) stepwise discriminant analysis, and (d) cluster analysis. The findings and inferences that could …
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Sensitivity of Diffuse Reflectance Spectroscopy to Dose- and Depth-dependent Changes in Tumor Oxygenation after Radiation Therapy
… of tumor vascular oxygen saturation can provide surrogate measures of tumor oxygenation to predict tumor response to therapy. The goal of this study is to determine the sensitivity of diffuse reflectance spectroscopy to changes in tumor oxygenation after single-dose radiation therapy in a …
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The Potential of Event Data Recorders to Improve Impact Injury Assessment in Real World Crashes
… the potential to eclipse the many traditional surrogate measures used in vehicle safety that often rely upon assumptions and simplifications of real world crashes. Although EDRs have been equipped in passenger vehicles for over two decades, the recent establishment of regulation has greatly …
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The role of neuromuscular performance on bone strength and properties in the forearm and lower leg of children
… poorly understood as limited evidence relies on surrogate measures of muscle force such as muscle size. The objective of this thesis was to explore the role of muscle area, peak forces from neuromuscular performance tests and physical activity in determining bone properties at the radius and …
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Evaluating Ramp Metering And Variable Speed Limits To Reduce Crash Potential On Congested Freeways Using Micro-simulation
Recent research at UCF into defining surrogate measures for identifying crash prone conditions on freeways has led to the introduction of several statistical models which can flag such conditions with a good degree of accuracy. Outputs from these models have the potential to be used as real-time …
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Exercise-Associated Cardiac Rhythm Disorders in Thoroughbred Racehorses
… Lifetime race starts and age were used as surrogate measures of exercise volume. Thoroughbred racehorses identified with both AF and SCD were younger than their racing peers, and therefore an association between exercise volume and cardiac arrhythmias was not found in this species. In both …
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