Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"surrogate marker"”.
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Theory and Algorithms for Penalization, Graphical Models, and Surrogate Marker Evaluation
… statistics theory, graphical models, and surrogate measures in clinical trials. First, we introduce a general slow rate bound for maximum regularized likelihood estimators in Kullback-Leibler divergence. The result applies to a wide variety of models and estimators where the densities have …
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The Role Of Tissue Sound Speed As A Surrogate Marker Of Breast Density
<p>Breast density is one of the strongest predictors of breast cancer risk as women with the densest breasts have a three- to five-fold increase in risk compared to women with the least dense breasts. Breast density is currently measured by using mammography, the current gold standard for breast …
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Mammographic breast density as a mediator and surrogate marker for breast cancer risk
Women with the highest mammographic density have a four to six-fold increased risk of breast cancer when compared to the ones with the least dense breasts. Mammographic breast density has also been associated with a wide array of factors related to the risk of breast cancer including age, …
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COPEPTIN AS A SURROGATE MARKER OF ARGININE VASOPRESSIN:CLINICAL DIAGNOSTIC AND PROGNOSTIC APPLICATIONS IN ENDOCRINE AND NON-ENDOCRINE DISEASES
… of laboratory assessment, it is used as a surrogate marker of AVP in several endocrine and non-endocrine disorders. AVP deficiency (previously known as central diabetes insipidus) is a disorder characterized by hypotonic polyuria with polydipsia. It may ensue after hypothalamus-pituitary …
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The Relationship of Level of Traumatic Exposure, Perceived Stress, and Resilience with Salivary Cortisol and Salivary Alpha-Amylase Diurnal Rhythm in Palestinian Children 10-12 Years Exposed to Chronic War Violence
… a long standing war zone. Salivary cortisol, a surrogate marker of hypothalamic-pituitary-adrenal axis (HPA) activity, and salivary alpha-amylase, a surrogate marker of sympathetic nervous system (SNS), have been used to explore relationships of studies psychoneurobiological factors and …
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Evaluating Magnetic Resonance Imaging and Serum Markers As Surrogate Endpoints for Clinical Trials in Cerebral Small Vessel Disease
… lacunar stroke and dementia conversion, imaging markers have been proposed as surrogate marker for phase-2 clinical trials. Results have shown that imaging markers such as DTI and some conventional MRI measures are sensitive to change over a few years and are further associated with later …
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Vascular Reactivity by Blood Oxygen Level Dependent Functional MRI in Cerebral Amyloid Angiopathy: Comparison with Alzheimer's Disease and Assessment of Longitudinal Change
… fMRI task has recently been implicated as a surrogate marker for impaired vascular reactivity in CAA. There have been no studies investigating how the BOLD amplitude changes in other Aβ diseases that present with CAA (Alzheimer’s disease (AD) or mild cognitive impairment (MCI)), or how it …
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Förster Resonance Energy Transfer-Based Quantification of D-2-Hydroxyglutarate & Locked Nucleic Acid Loop-Mediated Isothermal Amplification Mediated Detection of IDH1-R132 Single Nucleotide Variants in Glioma
… dehydrogenase 1 (<em>IDH1</em>) is a biomarker in gliomas which provides valuable information on patient prognosis and treatment. Targeted therapies including maximal surgical resection and pharmaceutical mutant IDH inhibitors offer life extending benefits; however, currently implemented …
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High A-scan rate optical coherence tomography angiography for blood flow speed quantification in the retina
… OCTA, designed to evaluate a quantitative surrogate marker for blood flow speed in the vasculature. At the capillary level, spatially compiled OCTA and a simple temporal autocorrelation model, ρ(τ) = exp(-ατ), are used to evaluate a temporal autocorrelation decay constant, α, as a marker …
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Image analysis of prostate cancer tissue biomarkers
… and prognosis, new sensitive and specific biomarkers are needed. Tissue biomarkers carry expression and morphological information of the tissue where they are expressed. However their use is still limited by technological problems, lack of standardized procedures and inadequate interpretation. …
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Detection and prediction of cardiac quiescence for computed tomography coronary angiography
… is an indication of electrical activity, it is a surrogate marker of the mechanical state of the heart. Therefore, gating based on a signal derived directly from cardiac motion using either echocardiography or seismocardiography (SCG) should prove better at detecting and predicting periods of …
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Validation of an adjusted calcium formula using the Roche calcium (NMBATPA) and albumin (BCG) methods at Groote Schuur Hospital
… (tCa) concentration for serum albumin as a surrogate marker of calcium status, despite the availability of ionised calcium (iCa) measurement. Current recommendations by the Association for Clinical Biochemistry and Laboratory Medicine (ACB) advocate that laboratories should use formulae …
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Constraints on the CD8 T cell response in chronic HBV infection
… correlated temporally with viral load and ALT (surrogate marker of liver inflammation) during spontaneous flares of CHB. B cells were shown to be a potent source of this cytokine upon CpG stimulation, and these ‘regulatory’ cells, identified as CD24 high CD38 high transitional, were selectively …
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Investigation of metabolism in glioblastoma patient-derived xenografts using deuterium metabolic imaging
… from 2H-labelled acetate can be used as a surrogate marker of fatty acid synthesis.
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HPV and p16 in head and neck cancer
… may suggest that p16 could potentially act as a surrogate marker of HPV16. However, the lack of concordance would suggest that in isolation p16 may not be a reliable marker for HR-HPV and should not be relied upon in isolation. Our findings could suggest that HPV16 and p16 status may be …
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Evaluation of two SARS-CoV-2 immunoassays
… used as a reliable, cheap, and easily accessible surrogate marker of post-vaccine humoral immune response and we recommend using this to confirm and monitor humoral immune response in patients with risk factors for non-seroconversion following vaccination and increased risk for morbidity and …
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Cytokine signaling control of naïve CD8⁺ T-cell homeostasis
… were predictably marked by expression of CD5, a surrogate marker of TCR:spMHC binding avidity. In vitro, CD5I T-cells proliferate more robustly to saturating levels of the y, interleukin (IL) cytokines IL-7, IL-2 and IL-15, while CD5" cells have prolonged survival in the absence of dedicated …
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Classification of Electroencephalogram in Ovine Model of Perinatal Hypoxia by Movement of the Autoregressive Model Parameters
… significant rates of morbidity. Therefore, a surrogate marker for “intact survival” is necessary for the management of HIE. The challenge is early detection of the severity of HIE at the point-of-care. The severity of HIE can be graded based on the clinical presentation including the presence …
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Ultrasound as a non-invasive diagnostic tool in paediatric neurosurgery : relationship between the optic nerve sheath diameter (ONSD) and intracranial pressure (ICP)
… the relevant pulsatile motion of the ONS as a marker of the sheath stiffness. Results: One hundred and seventy four children undergoing diagnostic or therapeutic surgical procedures were included in this study. ONSD measurement demonstrated good correlation with ICP across the entire patient …
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Enrichment of tomatoes and broccoli with specific bioactives for the reduction of prostate carcinogenesis
… between groups in genitourinary tract weight, a surrogate marker of tumor volume, and no differences were found in cancer grade upon histopathologic evaluation indicating that broccoli feeding did not impact cancer aggressiveness. The horticultural manipulation of broccoli to alter phytochemical …
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