Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"surrogate endpoints"”.
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Surrogate endpoints of survival in metastatic carcinoma
… quantified (1). Using an early proxy, or a surrogate endpoint, in place of the direct endpoint of overall survival (OS) could theoretically shorten the duration of RCTs and minimise the exposure of patients to ineffective or toxic treatments (2, 3). This thesis examined the relationship …
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Search for valid surrogate endpoints: review of current evidence and development of practical strategies for surrogate evaluation
… pursuit of more quickly available treatments, surrogate endpoint evaluation has become a vital part of drug development. Despite the increasing uptake of surrogate endpoints and the large number of statistical methods proposed to evaluate a surrogate, there is still no consensus on how to …
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Evaluating Magnetic Resonance Imaging and Serum Markers As Surrogate Endpoints for Clinical Trials in Cerebral Small Vessel Disease
… imaging markers have been proposed as surrogate marker for phase-2 clinical trials. Results have shown that imaging markers such as DTI and some conventional MRI measures are sensitive to change over a few years and are further associated with later clinical outcome events such as …
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Hazard assessment of a mixture of pharmaceuticals detected in the upper Tennessee River of Daphnia magna and the determination of riverine zooplankton assemblage as it relates to chitobiase activity
… in the Tennessee River using Daphnia- magna as a surrogate. Endpoints measured were time to first brood, reproduction, mortality, and number of neonates produced per adult reproduction day. Reproduction was the only endpoint that showed a significant effect. The LOEC of the pharmaceutical mixture …
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Ανάλυση κλινικών μελετών που υποστηρίζουν την υπό όρους άδεια κυκλοφορίας και την μετατροπή της σε κανονική άδεια κυκλοφορίας από τον Ευρωπαϊκό Οργανισμό Φαρμάκων (EMA) στην ογκολογία / Analysis of clinical trials supporting conditional marketing authorisation and its conversion to full marketing authorisation by the European Medicines Agency (EMA) in oncology
… πλήρως σε υποκατάστατα καταληκτικά σημεία (surrogate endpoints), με συχνότερο το Ποσοστό Αντικειμενικής Ανταπόκρισης (ORR). Η ποσοτική ανάλυση έδειξε σχετικό κίνδυνο χωρίς την Επιβίωση χωρίς Εξέλιξη της νόσου (HR PFS) στο 0,45 (0,37-0,55) για τα φάρμακα που αφορούν συμπαγείς όγκους με μέτρια …
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Effect of Physical Activity on Bone, Muscle and Fracture Risk during Growth
… less than one year and use bone traits as surrogate endpoints for fractures. The Pediatric Osteoporosis Prevention (POP) study is a prospective, controlled exercise intervention study, which was designed to annually assess musculoskeletal development and fracture risk in response to …