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Showing 1 to 20 of 22 for “"surfactant protein"”.

  1. Proteolytische Degradation von Surfactant Protein D

    Wiesener, AnnegretLudwig-Maximilians-Universität

    lmu-germany Repository record

  2. Wertigkeit von NT-proBNP, Surfactant Protein-B und Surfactant Protein-C als Marker zur Differentialdiagnose bei Patienten mit akuter Dyspnoe

    Schaumberg, Jens2012

    … Studien finden die lungenepithelspezifischen Surfactant-Proteine B (SP-B) und D (SP-D) als diagnostische Parameter Eingang in die weitere Abklärung einer Dyspnoe. Ziel dieser Untersuchung war es, die differentialdiagnostische Wertigkeit von NT-proBNP (N-terminales Spaltprodukt des brain …

    goettingen Repository record

  3. Identification and characterisation of novel interactors of surfactant protein C

    Ying, HaoyangUniversity of Cambridge2023

    Inherited pathogenic variants of surfactant protein C (SFTPC) can cause familial pulmonary fibrosis. The most common, SFTPC-I73T, aberrantly localises to the plasma membrane and causes alveolar type 2 (AT2) dysfunction via a poorly understood toxic gain-of-function. Understanding the mechanisms of …

    cambridge Repository record

  4. Characterisation of surfactant protein a as a novel prophylactic means against oncogenic HPV infections

    Carse, SineadDivision of Medical Biochemistry2024

    … HPV infection, our previous research identified surfactant protein A (SP-A), an innate immune opsonin, as a novel molecule capable of recognising HPV16 pseudovirions (HPV16-PsVs) with functional consequences for reduced infection in a murine cervicovaginal HPV challenge model. Building on these …

    cape-town Repository record

  5. Pseudomonas aeruginosa Type IV pilus and resistance to the antimicrobial properties of surfactant protein-A

    Tan, Rommel MaxUniversity of Illinois at Urbana-Champaign2014

    … numerous innate immune cells and effector proteins. One important component of this immune system is the surfactant protein-A (SP-A), which facilitates microbial clearance by opsonization and membrane permeabilization. Pseudomonas aeruginosa (PA) is a major Gram-negative bacterial pathogen …

    uiuc Repository record

  6. Characterisation of human surfactant protein A and recombinant human vimentin in their modulation of HPV16 pseudovirus infection

    Carse, SineadDepartment of Integrative Biomedical Sciences (IBMS)2019

    … cancer progression are needed. Two human proteins have been identified in our laboratory that modulate HPV16 pseudovirus (HPV16-PsVs) infection in vitro, namely surfactant protein A (SP-A) and recombinant human vimentin (rhVim). Previous work suggested SP-A mediated immune recognition of …

    cape-town Repository record

  7. Regulation of Adaptive Immunity in the Lung by the Alveolar Epithelial Type II Cell and Surfactant Protein a

    Lo, Bernice2008

    … type II cell and its secretory product, surfactant protein A (SP-A), have been linked to roles in adaptive immunity in the lung. The discovery that type II cells constitutively express major histocompatibility complex class II (MHC II) suggested that type II cells may function to present …

    duke Repository record

  8. Investigation of respiratory surfactant A protein in middle ear epithelium

    Cecire, AnthonyThe University of Waikato2020

    … that of the lungs. Lung function depends upon surfactant which is a family of surfactant proteins which have an important role in breathing as well as infection control. Given that both the middle ear and the lungs can suffer collapse as well as infection, it is worth exploring whether …

    waikato-masters Repository record

  9. YAP/TAZ REGULATES ALVEOLAR REGENERATION AND RESOLUTION OF LUNG INFLAMMATION

    LaCanna, RyanTemple University. Libraries2019

    … resolution of lung inflammation. We show that surfactant protein C-expressing (SPC-expressing) alveolar epithelial type II cells (AECIIs) underwent proliferation and differentiation after infection, which contributes to the newly formed alveolar epithelium. This increase in AECII activities was …

    temple Repository record

  10. The role of Surfacant Protein D in the control of human helminth infections

    Baker, ZoeDivision of Immunology2020

    Lung produced surfactant protein D (SP-D) is essential for both homeostasis and as an innate immune opsonin. In the project presented here, we aimed to translate data recently published by our group, which demonstrated that SP-D contributes to protection against murine parasitic nematode …

    cape-town Repository record

  11. Roles of MicroRNAs in Fetal Lung Development

    Guo, Wei2018

    Lung alveolar type II cells uniquely synthesize surfactant, a developmentally-regulated lipoprotein that is essential for breathing. Expression of the major surfactant protein, SP-A, in midgestation human fetal lung (HFL) is dramatically induced by cAMP. cAMP induction of SP-A expression is …

    utswmed Repository record

  12. EFFECTS OF DAPAGLIFLOZIN ON EXERCISE CAPACITY, RESPIRATORY FUNCTION, BIOMARKERS, SLEEP APNEA, AND LEFT VENTRICULAR REMODELING IN PATIENTS WITH HEART FAILURE: A PROSPECTIVE, SINGLE CENTER, NON RANDOMIZED STUDY

    VIGNATI, CARLOUniversità degli Studi di Milano2026

    … alveolar-capillary membrane function through surfactant protein-B (proSP-B), gas exchange, and sleep-disordered breathing. Evaluations were performed at baseline, 2–4 weeks, and after 6 months of treatment with dapagliflozin 10 mg/day. Results: Among 75 patients enrolled, 67 completed full …

    milano Repository record

  13. Amiodarone-induced pulmonary toxicity in F344 rats

    Taylor, Michael Douglas2019

    … pulmonary fibrosis. Also, serum levels of surfactant protein-D, a protein normally found in the lungs, was elevated in the serum of i.t. AD-treated rats, and is proposed as a biomarker for the toxicity. However, attempts to elucidate the cytokine signaling behind the inflammatory events …

    wvu Repository record

  14. Exploiting the potential of foam nests produced by Engystomops pustulosus

    Brozio, SarahUniversity of Strathclyde2018

    … sperm ortadpoles. Amphibians produce a range of proteins and peptides that may have pharmaceutical utility, and this is a growing area of research. This work investigated the potential of the foam-nest produced by E. pustulosus as a novel drug release system. Bioinformatics were used to gain …

    strathclyde Repository record

  15. A study of the causes and consequences of SFTPC mistrafficking in alveolar type 2 cells using novel organoid models

    Rutherford, Eimear NiamhUniversity of Cambridge2023

    … 2 (AT2) cells, which in health produce pulmonary surfactant and act as progenitor cells to enable epithelial repair. AT2 cell dysfunction results in failed alveolar re-epithelisation and fibroblast recruitment, activation, and proliferation but the cellular mechanisms underlying this are poorly …

    cambridge Repository record

  16. The role of pulmonary innate and adaptive immune responses to helminth infection

    Thawer, Sumaiyya GDepartment of Clinical Laboratory Sciences2014

    … pulmonary epithelial cell-secreted collectin, surfactant protein D (SP-D), is an important component of host immunity to N. brasiliensis infection. We demonstrate here that SP-D production is induced following N. brasiliensis infection in a Th2 dependent manner, it bound preferentially to lung …

    cape-town Repository record

  17. The role of pulmonary innate and adaptive immune responses to helminth infection

    Thawer, Sumaiyya GDepartment of Clinical Laboratory Sciences2014

    … pulmonary epithelial cell-secreted collectin, surfactant protein D (SP-D), is an important component of host immunity to N. brasiliensis infection. We demonstrate here that SP-D production is induced following N. brasiliensis infection in a Th2 dependent manner, it bound preferentially to lung …

    cape-town Repository record

  18. Directed Evolution of Glycan-Binding Proteins

    Ward, Elizabeth M.Massachusetts Institute of Technology2022

    Glycan-binding proteins (GBPs) are commonly used reagents for the study of glycans. They do not require specialized equipment or time-consuming experimental methods, making them widely used tools for basic research and clinical applications. Existing glycan recognition reagents,antibodies and …

    mit Repository record

  19. Effects of the Non-ionic Surfactant Tween 80 on the Enzymatic Hydrolysis of Model Cellulose and Lignocellulosic Substrates

    Jiang, FengVirginia Tech2011

    Non-ionic surfactants are known to enhance the biochemical conversion of lignocellulosic (LC) biomass to bioethanol. Their mechanisms of action, however, are incompletely understood. This research was conducted to elucidate the effects of the non-ionic surfactant Tween 80 on the enzymatic …

    vt Repository record

  20. Improving Collagen-Mimetic Fibrils to Study Fibrillogenesis and Effects of Disease-Causing Mutations on Fibrillogenesis

    Dewan, FaizunnaharThe Graduate School and University Center of The City University of New York2023

    <p>Collagen, the most abundant protein in the human body, serves as the scaffold of connective tissue and has biomaterial applications to promote wound healing. The need to study collagen further stems from a disease perspective, as mutations in collagen lead to numerous connective tissue diseases. …

    cuny-grad Repository record

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