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Showing 1 to 20 of 203 for “"surface-expression"”.

  1. Deformation and its surface expression in stressed planetary materials

    … geophysical properties observable from planetary surfaces. When forces change within rocky and icy layers of planetary bodies, constituent materials of these layers adjust on the microscale; energetically favorable alignment of microstructural materials builds across scales to result in …

    mit Repository record for Deformation and its surface expression in stressed planetary materials (opens in a new tab)

  2. CHIC2 and STUB1 regulate interferon-γ receptor cell surface expression

    The regulated expression of cell surface receptors is essential for cellular homeostasis and defective in disease states. Receptor regulation is particularly important as receptor internalization limits the duration and intensity of substrate signaling. Interferon-γ (IFN-γ), a critical antiviral …

    cambridge Repository record for CHIC2 and STUB1 regulate interferon-γ receptor cell surface expression (opens in a new tab)

  3. N-linked glycosylation is fundamentally linked to the surface expression of neuroligins

    … modification, decorating secreted and cell-surface transmembrane proteins as they are trafficked along the secretory pathway. While well-characterized in most tissues, non-canonical N-glycan diversification has been reported to occur in the central nervous system. Chapter 2 of this …

    colostate Repository record for N-linked glycosylation is fundamentally linked to the surface expression of neuroligins (opens in a new tab)

  4. The Oncogenic Map Kinase Signaling Pathway Modulates Mhc-I Surface Expression In Melanoma

    … in tumor cells can affect the level of expression of major histocompatibility complex I molecules (MHC-I) on the cell surface, and potentially allow melanoma cells to escape immune system surveillance. MHC-I molecules expressed by tumor cells are the crucial targets recognized by CTLs to …

    uthsc Repository record for The Oncogenic Map Kinase Signaling Pathway Modulates Mhc-I Surface Expression In Melanoma (opens in a new tab)

  5. N-linked glycosylation of ether á go-go potassium channels: effects on cell surface expression and functional properties

    … hervorgerufen, da der gleiche Effekt bei der Expression des Wildtyp-Proteins in Zellen mit mangelnder Glykosylierung beobachtet wird. Obwohl das unglykosylierte Protein teilweise im Endoplasmatischen Retikulum festgehalten wird, muss ein wesentlicher Bestand der Mutanten-Kanäle an der …

    goettingen Repository record for N-linked glycosylation of ether á go-go potassium channels: effects on cell surface expression and functional properties (opens in a new tab)

  6. Kinetics and Intracellular Pathways Required for MHC Ii-Peptide Loading and Surface Expression of a Hapten-Protein Conjugate in Murine Macrophage

    … and that MHC II-peptide complexes reach the surface of the cell via the existing endocytic machinery in transferrin receptor positive compartments. These studies also suggested that a novel macrophage surface receptor specific for polyaromatic compounds affected the processing of the probe by …

    uiuc Repository record for Kinetics and Intracellular Pathways Required for MHC Ii-Peptide Loading and Surface Expression of a Hapten-Protein Conjugate in Murine Macrophage (opens in a new tab)

  7. The role of C-terminal cysteines in regulating human proteinase-activated receptor-1 function

    … a profound effect on GPCR function such as cell surface expression and receptor signalling, the role of palmitoylation in regulating PAR function is currently unknown. This study focused on the role of putative palmitoylation region of hPAR1--C-terminal cysteines (C387and C388) in regulating …

    hull Repository record for The role of C-terminal cysteines in regulating human proteinase-activated receptor-1 function (opens in a new tab)

  8. Altered Expression of Costimulatory Molecules in Behcet's Disease According to Clinical Activity

    … molecules in BD. I investigated cell surface expression of CTLA-4 and PD-1 on T cells and Treg cells, as well as cell surface expression of CD80, CD86, PD-L1 on antigen presenting cells (APCs). Also, I measured the concentration of soluble CTLA-4 (sCTLA-4) from serum and culture …

    ajou Repository record for Altered Expression of Costimulatory Molecules in Behcet's Disease According to Clinical Activity (opens in a new tab)

  9. CELLULAR AND MOLECULAR MECHANISMS OF AT2R MEDIATED ANTI-PROTEINURIC ACTIVITY

    … of high sodium (4%) diet (HSD) on the expression of protein endocytic receptor megalin and its impact on proteinuria, particularly in obesity is not known. There are indications suggesting the involvement of glycogen synthase kinase (GSK)-3β-mediated megalin phosphorylation, and its …

    houston Repository record for CELLULAR AND MOLECULAR MECHANISMS OF AT2R MEDIATED ANTI-PROTEINURIC ACTIVITY (opens in a new tab)

  10. Expression Profiles of Molecules Involved in Antigen Presentation in Gangliosides-stimulated Primary Astrocytes from Rat brain

    … I tested whether gangliosides could induce the expression of immune molecules related to antigen presentation, using cultured rat brain glial cells, astrocytes and microglia. I treated cells with 50 ug/ml gangliosides mixture (Gmix) for 6 h to 3 d, and assayed the mRNA expression of class II …

    ajou Repository record for Expression Profiles of Molecules Involved in Antigen Presentation in Gangliosides-stimulated Primary Astrocytes from Rat brain (opens in a new tab)

  11. Immune reconstitution post bone marrow transplantation

    … autologous grafts. to document the cell surface expression of CD95 in an attempt to comment on the role played by FAS mediated apoptosis in the post transplant immune deficiency.

    cape-town Repository record for Immune reconstitution post bone marrow transplantation (opens in a new tab)

  12. Contribution of the Membrane-Proximal Region of the Vesicular Stomatitis Virus Glycoprotein to Host Cell Entry and Membrane Fusion

    … lifecycle of the virus, is mediated by the outer surface protein, G and will be the focus of this dissertation. </p> <p>We hypothesize that the highly conserved residues in the membrane-proximal region of VSV G protein are critical to membrane fusion through participation in low pH-induced …

    tenn-hsc Repository record for Contribution of the Membrane-Proximal Region of the Vesicular Stomatitis Virus Glycoprotein to Host Cell Entry and Membrane Fusion (opens in a new tab)

  13. The role of intracellular and extracellular cysteines in regulating human proteinase-activated receptor-2 (hPAR2) function

    … of C226 resulted in ablation of receptor cell surface expression and intracellular retention of receptor. Mutagenic removal of C148 resulted a receptor successfully expressed at the plasma membrane with only a small reduction in cell surface expression over wildtype. The hPAR2C148A mutant still …

    hull Repository record for The role of intracellular and extracellular cysteines in regulating human proteinase-activated receptor-2 (hPAR2) function (opens in a new tab)

  14. Die Regulation der Expression des humanen Oncostatin-M-Rezeptors durch Januskinasen

    … in the present study: Upon heterologous expression of the OSMR in several cell lines, its surface expression was significantly enhanced by coexpression of the Janus kinases Jak1, Jak2 and Tyk2 but not Jak3. This effect was not an overexpression artefact, as the endogenous OSMR was also …

    aachen Repository record for Die Regulation der Expression des humanen Oncostatin-M-Rezeptors durch Januskinasen (opens in a new tab)

  15. Differential expression of beta 2 integrins in Korean Behcet’s disease patients

    … possible relationship between beta 2 integrins expression and BD. Materials and methods: BD patients (n=51) consisting of 22 active patients and 29 inactive patients, 20 recurrent aphthous ulcer (RAU) patients and 23 healthy controls (HC) were included. The expression of CD11a, CD11b, CD11c, as …

    ajou Repository record for Differential expression of beta 2 integrins in Korean Behcet’s disease patients (opens in a new tab)

  16. Analyzing the Interactions Between Xenopus tropicalis MC2R, MC5R, and the MRAPs: Modeling the Regulation of Frog Interrenal Cells

    … The MRAPs have an opposite effect on the cell surface expression of MC2R and MC5R. In mammals, MRAP aids MC2R but inhibits MC5R cell surface expression. This thesis aims to explore the functional relationship between MC2R, MC5R, MRAP, and MRAP2 in<em> Xenopus tropicalis</em> to determine if the …

    denver Repository record for Analyzing the Interactions Between Xenopus tropicalis MC2R, MC5R, and the MRAPs: Modeling the Regulation of Frog Interrenal Cells (opens in a new tab)

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