Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 150 for “"surface receptors"”.
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Platelet surface receptors and melanoma metastasis
Ziel dieser Arbeit war es, die Rollen der Plättchen-Rezeptoren GPVI und GPIbα bei der hämatogenen Melanom-Metastasierung zu untersuchen. Die letzten Jahrzehnte haben zunehmend Indizien für eine Beteiligung von Plättchen und Plättchen-Rezeptoren bei der hämatogenen Tumor-Metastasierung geliefert. …
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Quantitative Analysis of the Spatial and Temporal Organization of Cell Surface Receptors
Appendix B contains a previously published article, which is referenced below as a related citation.
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Investigation of in-situ nanoimprinting of cell surface receptors: potential of a novel technique in biomarker research
… among patients and disease stages. Cell surface receptors, proteins that are located at the cell surface and deliver external signals into the cell, are a significant group of easily-detectable biomarkers. Along with the detection of particular biomarkers related to a disease, extensive …
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Real Time PCR-Based Infectivity Assay and Characterization of Cell Surface Receptors for Turkey Hemorrhagic Enteritis Virus
… the B lymphoblastoid, RP19 cells. The cellular surface components used by the virus to gain entry into cells are unknown. As an adenovirus, we hypothesized that THEV uses two different molecules on RP19 cells for the attachment and internalization. A recent study has shown that the synthesized …
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Evaluation of Peptides and Peptide–Doxorubicin Conjugates Designed and Synthesized for Targeting Triple-Negative Breast Cancer via Cell-Surface Receptors
<p>A significant problem faced in oncology is the lack of chemotherapeutic agents that are tumor site-specific, resulting in reduced therapeutic efficacy and unintended infliction of harm to surrounding healthy tissues and cells that often lead to serious side effects. Current strategies being …
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Genome-scale identification of cellular pathways required for cell surface recognition
… organisms. Interactions mediated by cell surface receptors can be challenging to detect in biochemical assays, because they are often highly transient, and membrane-embedded receptors are difficult to solubilise in their native conformation. The biochemical features of low-affinity …
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Resolving Signal Transduction in Complex Biological Environments
Cell surface receptors reside in complex biological environments along with their numerous extracellular ligands to transduce information across the membrane bilayer. These receptors regulate major functions including cell proliferation, facilitation of neuronal transmission, cell growth and …
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Experimental and modeling studies of endosomal sorting using the epidermal growth factor/receptor system in fibroblasts
… which have specifically interacted with cell surface receptors. Cells have the ability to sort internalized ligands and their receptors to lysosomes for degradation, to recycle them back to the plasma membrane, or to sort ligands and receptors to separate destinations. We are interested in …
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Regulation of Neuronal Polarity by Wnt Signaling
… function in many developmental processes. Cell surface receptors, including the Frizzleds (Fz), ROR, and RYK families of proteins, bind Wnts to activate a number of downstream pathways. Wnts act redundantly to regulate the anteroposterior polarity of mechanosensory neurons ALM and PLM in C. …
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Defining interactions between Mycobacterium leprae and Langerhans cells
… interacts with Langerhans cells via various cell surface receptors that influence a Th1 or Th2 immune response. This study interrogates the complex interactions between Mycobacterium leprae and Langerhans cells via multiple cell surface receptors. In Chapter 2, an ex vivo optical tissue clearing …
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Computational Studies of Autocrine Ligand Binding
Autocrine ligand secretion and binding to cell surface receptors regulate cell behavior in a number of important physiological functions. At the same time, some pathological conditions such as the unmitigated growth of tumors can also act through this type of stimulation. Interpretation of …
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The recognition of lipopolysaccharides present in Gram-negative bacteria by receptors of the immune system
… this is achieved partly through specific cell surface receptors, some of which are involved in bacterial recognition. One virulent pathogen that binds cell surface receptors and triggers immune cells to overproduce pro-inflammatory cytokines is gram-negative bacteria. This pathogen is covered …
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Proliferative and survival pathways in oesophageal cancer
… potentially improving management of OSCC. Cell surface receptors are known to play important roles in relaying signals from the extracellular environment...The aim of this study was to determine the role of EGFR, IGF-1R and CXCR2 in proliferation and survival of OSCC cells.
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Extracellular Interaction Screening Using CRISPR Activation
Extracellular interactions between cell surface receptors are necessary for signaling and adhesion but identifying them remains technically challenging. We describe a cell-based genome-wide approach employing CRISPR activation to identify receptors for a defined ligand. We show receptors for …
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The Regulation of Phosphorylation Events in Platelets
… subendothelial matrixes. The binding of platelet surface receptor Glycoprotein VI (GPVI) to exposed collagen initiates a signaling cascade, which culminates in platelet activation. Stimulation of GPVI pathways results in the generation of thromboxane and causes the platelets to secrete their …
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Bioactive Lipids in Nociception
… including TRPV1, are regulated by PLC-coupled surface receptors. After PLC-dependent cleavage of phosphatidylinositol bisphosphate into diacylglycerol (DAG) and inositoltrisphosphate, diacylglycerol may be further metabolized to monoacyl-glycerols, such as 2-arachidonoylglycerol (2-AG) and …
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Antigenic Determinants on the Surface of Granulocytes of Battella Germanica
… it was studied to determine how many antigenic surface receptors it contained on its membrane. The study began by injecting New Zealand rabbits with granulocytes, isolated from the German cockroach to stimulate antibody production. Using rabbit antigranulocytes serum for Western blot analysis, …
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Design, Synthesis and Evaluation of Diphenylamines as MEK5 Inhibitors
… mitogens or the binding of other ligands to cell-surface receptors begin a signaling cascade that activates MEK resulting in phosphorylation of its corresponding and specific and parallel ERK (Extracellular signal-Regulated Kinase) substrate. The MEK5/ERK5 pathway is involved in cell survival, …
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Mannose and Lipopolysaccharide Receptors on the Surface of Granular Hemocytes from the Crayfish <em>Procambarus clarkii</em>.
… of two different pattern recognition cell surface receptors on this subpopulation of granular hemocytes from the red swamp crayfish, <em>Procambarus clarkii</em>, which may specifically recognize and bind to both LPS from gram-negative bacteria and to mannose containing glycoproteins found …
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Purinergic Receptors in the Circumvallate Papillae of Rats
<p>P2X2 receptors and P2Y4 receptors are ATP-activated cell surface receptors that gate movement of K+, Na+, and Ca2+. We used immunocytochemistry for P2X2 and P2Y4 receptors as well as taste cell type markers to learn if P2X2 immunoreactivity (IR) is present in nerve processes in close apposition …
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