Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 101 for “"surface proteins"”.
-
Molecular studies on streptococcal surface proteins
… diseases. This thesis focuses on a number of surface proteins expressed by S. agalactiae and S. pyogenes and, more specifically, the molecular and biological characterization of these proteins. The first paper describes the novel Blr protein of S. agalactiae, which together with the previously …
-
Characterization of the Surface Proteins of the Anatid herpesvirus
… sucrose gradients. A total of 17 putative virus proteins were consistently identified in both polyacrylamide gel electrophoresis and radioautogram. Coomassie blue staining techniques identified 10 virus bands. The remaining 7 virus proteins were identified using radioautography. AHV polypeptides …
-
Assembly and Display of Surface Proteins In Actinomyces Oris
… 700 individual bacterial species colonizing oral surfaces and forming a multispecies biofilm. These biofilms are the cause of prevalent human diseases such as dental caries, gingivitis, and periodontitis. The microbes present in the oral biofilm are highly spatially and temporally structured and …
-
Surface proteins of Finegoldia magna interacting with the human host
… identification and characterization of two novel surface proteins of F. magna. One of the identified proteins, SufA, is a protease belonging to the subtilase family. This protease cleaves and inactivates the antimicrobial peptide LL-37 and the antibacterial chemokine MIG/CXCL9. Furthermore, the …
-
Expression and behaviour of GPI-anchored surface proteins in trypanosomes
… trypanosome species have evolved a variant surface glycoprotein (VSG) coat which underpins a population survival strategy based on antigenic variation. However, the vast majority of trypanosome species do not use this strategy and our understanding of the immune evasion strategies used by …
-
Regulation of Surface Proteins Assembly on the Wall of Gram-Positive Bacteria
<p>Cell wall peptidoglycan-anchored surface proteins are essential virulence factors in many Gram-positive bacteria. Attachment of these proteins to the peptidoglycan is achieved through a transpeptidation reaction, whereby sortase cleaves a conserved Cterminal LPXTG motif and attaches the protein …
-
Characterisation of the pre-invasion glycophosphatidylinositol-anchored surface proteins of Plasmodium falciparum merozoites
… Glycophosphatidylinositol (GPI) -anchored proteins cover most of the exterior surface of the merozoite prior to invasion, while other GPI-anchored proteins are released onto the merozoite surface through apical organelle secretions. These proteins are involved in interactions with …
-
Der Einfluß der Outer surface proteins von Borrelia burgdorferi auf die Transkriptionsfaktoren NF-kB und AP-1
Die Outer surface proteins (Osp) von Borrelia burgdorferi sind ein zentraler Faktor bei der Pathogenese der Lyme-Borreliose. In vitro reagieren humane Endothelzellen, Fibroblasten, Makrophagen und Monozyten auf die Outer surface proteins mit der Aktivierung des Transkriptionsfaktors NF-kappa B. In …
-
Molecular and microscopical analysis of pathogenic streptococci - studies on surface proteins interacting with human cells and extracellular matrix
… within its host. Interactions between bacterial surface structures and human proteins might determine the outcome of the infection. Streptococcus pyogenes (S. pyogenes), is a human pathogen mostly causing localized infections of the skin and respiratory tract, but it is also capable of causing …
-
APPROACHES TO IDENTIFY SURFACE PROTEINS OF ANAPLASMA PHAGOCYTOPHILUM DENSE-CORED ORGANISMS AS ADHESINS TO HUMAN P-SELECTIN GLYCOPROTEIN LIGAND-1
… identified. In this study, we sought to identify surface proteins of A. phagocytophilum as putative adhesins. A. phagocytophilum undergoes a biphasic developmental cycle, transitioning between a smaller electron dense-cored cell (DC), which has a dense nucleoid, and a larger, pleomorphic electron …
-
A study of the influence of sperm surface proteins on the activity of avian spermatozoa In-vitro and In-vivo
… for mammals. Association of secreted epididymal proteins and glycoproteins with the sperm surface appears to be complete at the anterior ductus deferens. However, antigenic change to, and glycosylation and deglycosylation of seminal plasma and sperm surface-associated proteins, selective loss of …
-
Adaptive Evolution of Surface Proteins in Microbial Pathogens: Lyme Disease Pathogens (Borreliella sp.) and Human Immunodeficiency Virus Type 1 (HIV-1)
<p>Cell and virion surface proteins are key to the survival and adaptation of microbial pathogens by enabling them to evade host immune responses and to persist in diverse environments. Pathogens respond to host immune pressures with genetic changes in surface proteins through mechanisms including …
-
Technologies to decode the multicellular networks within the human body
… Its subject is principally centered around the proteins that cover the surfaces of human cells. These proteins have to bind with specific combinations of surface proteins on nearby cells, thereby establishing a complex ‘code’ of direct interactions possible between different cell populations and …
-
Investigating the molecular mechanisms of the interactions between Lactobacillus reuteri strains and intestinal mucus
… genetic and protein level of two specific cell surface proteins, MUB and Lar_0958, expressed by the ATCC 53608 strain and human strains, respectively and their role in mediating mucus binding and autoaggregation ability of L. reuteri strains, as determined by flow-cytometry and in vitro mucus …
-
Streptococcal virulence and the coagulation system.
… We describe interactions between streptococcal surface proteins and components of the intrinsic pathway of coagulation and the kallikrein-kinin system in human plasma, as well as to how these surface proteins are produced in different growth phases. The interactions involve activation of the …
-
Analyzing Extracellular Vesicles for Disease Monitoring in Metastatic Colorectal Cancer Patients
… in cancer cell-to-cell communication and carry surface proteins and cell-specific cargos of nucleic acids. For this reason, we aimed to characterize ribonucleic acid (RNA) cargoes and surface proteins on EVs disseminated from CRC cancer cells to longitudinally monitor mCRC patients and identify …
-
Analysis of the Tumour Microenvironment in CLL
… third part of the thesis focuses on cell surface proteins which allow CLL cells to communicate with other cells. In order to obtain a comprehensive analysis of the cell surface proteome of CLL cells, we developed a method utilising cell impermeable, cleavable sulfo-NHS-SS-biotin to enrich …
-
Computational discovery and modelling of tandem domain repeats in proteins
Domains are functional and evolutionary units of proteins that typically fold into stable globular structures. A small subset of natural multidomain proteins contain large arrays of nearly identical domains repeated in tandem, challenging some of our assumptions about protein folding and evolution. …
Page 1 of 6