Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 96 for “"surface markers"”.
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An unbiased proteomic approach to identifying cell surface markers in neutrophils
Introduction: Efferocytosis refers to the engulfment of dead cells by phagocytes such as neutrophils and macrophages and culminates in the beneficial removal of inflammatory cargo and auto-reactive material. While many of the mechanisms involved in efferocytosis have been described, the critically …
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A coherent point drift algorithm for breast image registration via surface markers
… of breast tissue matching using fiducial surface markers in two different arm positions. The registration algorithm uses the surface markers only and does not employ the image intensities. In this Thesis, I apply and evaluate a coherent point drift (CPD) algorithm for registration of 3D …
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Protein L Functionalized Microparticles For Early Detection of Surface Markers In Heterogeneous Colorectal Lesions
… of the tumor landscape has identified surface antigens that can be utilized to distinguish normal and cancerous tissue lining the colonic lumen. Use of antibodies conjugated to nano/micromaterials offers a means to detect these antigens, however, the heterogeneous nature of tumors makes …
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Use of artificial neural network techniques to model proteomics of cellular stress
… sure that these key antigens remain on the cell surface during the manufacturing process is essential to make a viable product. Performing cellular stress experiments on an industrial scale would prove far too costly; instead an ultra-scale down model is used here to mimic the effects of a large …
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CHARACTERISING THE REPROGRAMMING DYNAMICS BETWEEN HUMAN PLURIPOTENT STATES
… reprogramming. Comprehensive profiling of cell-surface markers by flow cytometry in naïve and primed hPSCs revealed pluripotent state-specific antibodies. By compiling the identified state-specific markers into a multiplexed antibody panel, I was able to distinguish naïve and primed hPSCs. …
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Effects of Carboxylated Nanodiamonds on Macrophages During and After Differentiation
… the percent of cells expressing macrophage surface markers. Nonetheless, ND exposure reduced the number of surface markers expressed on each cell. My findings suggest that ND are not cytotoxic to macrophages at the tested concentrations, but they can interfere with macrophage functions and …
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Defining the Transcriptional and Epigenetic Signature of Mouse Embryonic Stem Cells with Compromised Developmental Potency
… changes in the transcriptome, epigenome or cell surface markers that have occurred in these compromised ES cells and to further define the developmental phenotype of the chimaeric embryos. Different stages during development were analysed and whereas there was little difference in embryonic death …
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Extracellular Vesicle Capture and microRNA Detection
… the discovery of novel, easily accessible biomarkers via liquid biopsies. Extracellular vesicles have shown promise as a noninvasive biomarker for disease diagnosis and monitoring, and have become a treasure trove of information because they have been found to carry proteins, DNA, mRNA and …
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Forward programming of human pluripotent stem cells to a megakaryocyte-erythrocyte bi-potent progenitor population: an in vitro system for the production of platelets and red blood cells for transfusion medicine.
… combined with index sorting of different cell surface markers, to allow retrospective analysis of cells which successfully generate colonies. The aim of this work is to better characterise the progenitor cells produced by forward programming, to allow further study of this cell type. Single …
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Generierung von Transposonmutanten des Epstein-Barr-Virus zur Charakterisierung von Genfunktionen für die lytische Virusvermehrung und die virale Latenz
… and with regard to a modulated expression of surface markers (CD11a, CD23, CD30, CD40, CD44, CD54, CD58). Wildtype EBV infected cells and uninfected cells were used as controls. Both mutants expressed a subset of the investigated genes for a short period. An increased surface marker expression …
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DESIGNING BIOMIMETIC NANOPARTICLES TO TACKLE INTRACELLULAR PATHOGENS
… plasma membrane origin and preservation of surface glycocalyx profiles. Partial retention of surface markers like CD14 (CD14+ monocyte-derived NGs) and CD11a (THP-1 cells derived NGs) was observed. Taken together, the lectin staining results and the detection of surface markers using …
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Understanding adipokine secretion and adipocyte-macrophage cellular interactions, in search for the molecular basis of insulin sensitivity and resistance
… WAT increased expression of mature macrophage surface markers and transcript levels of proinflammatory cytokines compared to C2D cells in vitro. However, macrophages isolated from BAT expressed low levels of cytokines and macrophage surface markers.
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A Molecular Basis for Macrophage Control of Enteric Nervous System Function
… associated with enteric neurons and expressed surface markers characteristic of nerve-adjacent macrophages in other tissues. Mice with a macrophage-specific deletion of C1qa showed changes in enteric neuronal gene expression, increased peristaltic activity, and accelerated intestinal transit. …
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Überexpression von s-Adenosylhomocystein-Hydrolase (SAH) in Zellen der Epstein-Barr Virus-Genom positiven Zell-Linie B95-8
… B95-8 cells. A modulated expression of surface markers CD11a, CD19, CD23, CD30, CD40, CD44, CD54, and CD58 has not been detected. The clarification of reaction mechanisms to activate the lytic cycle is an important step for the development of substances to therapy EBV associated tumors.
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NANOPARTICLE BASED MULTI-MODAL THERAPIES AGAINST TRIPLE-NEGATIVE BREAST CANCER
… and lethal form of breast cancer that lacks surface markers commonly targeted by hormone or immunotherapies. Silver nanoparticles (AgNPs) have exhibited a selective toxicity against TNBC cell lines at concentrations that are not lethal to non-tumorigenic cells, which makes them a candidate …
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ELUCIDATING REGULATORY NETWORKS PROMOTING B-CELL DEVELOPMENT
… commitment. Based on the combined expression of surface markers and transgenic reporter genes, we have identified three hierarchically related and functionally distinct subpopulations within the common lymphoid progenitor (CLP) compartment. Using this knowledge, we have re-evaluated previously …
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The effects of hyaluronic acid and exercise on equine skeletal muscle
… global expression of macrophage and neutrophil surface markers (NCF2, ELANE, CD168I). These results determine that HA treatment does act as an anti-inflammatory in equine skeletal muscle but does not possess prolonged effects with the initiation of inflammation.
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Novel approaches to investigate behaviors of bacteria by atomic force microscopy and circulating tumor cells through microfluidics
… functionalized with antibodies that bind to surface markers on activated platelets.
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Immune Function Determination in Mice Dermally Exposed to Permethrin
… phagocytic activity was not affected. Cell surface markers of thymocytes, splenocytes and bone marrow cells were not affected. Antibody production as shown by plaque forming cell (PFC) assay decreased significantly at 10 days after dosing termination. Taken together, these data indicate that …
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