Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"suppressor of cytokine signalling 3"”.
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The conservation of suppressor of Cytokine Signalling 3 in mediating intestinal homeostasis
A key function of the gastrointestinal tract is to break down ingested food and absorb the contained nutrients and water. Within the intestinal tract are a number of specialised epithelial cells that aid in this process as well as maintaining immune homeostasis through their functioning as a …
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Suppressor of cytokine signalling 3 (SOCS3) turnover and regulation of human saphenous vein smooth muscle cell signalling and function
… cell (SMC) inflammation and proliferation. Suppressor of cytokine signalling 3 (SOCS3) limits Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathways involved in vascular remodelling but is limited by its short biological half-life. Therefore, mutation of all 9 …
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Suppressor of cytokine signalling 3 (SOCS3) turnover and regulation of human saphenous vein smooth muscle cell signalling and function
… cell (SMC) inflammation and proliferation. Suppressor of cytokine signalling 3 (SOCS3) limits Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathways involved in vascular remodelling but is limited by its short biological half-life. Therefore, mutation of all 9 …
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Suppressor of cytokine signalling 3 (SOCS3) turnover and regulation of human saphenous vein smooth muscle cell signalling and function
… cell (SMC) inflammation and proliferation. Suppressor of cytokine signalling 3 (SOCS3) limits Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathways involved in vascular remodelling but is limited by its short biological half-life. Therefore, mutation of all 9 …
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Prostanoid-mediated Inhibition of IL-6 Trans-Signalling in Pulmonary Arterial Hypertension: a Role for Suppressor of Cytokine Signalling 3?
… disease with no cure. Current treatment consists of a cocktail of vasodilators which relieve symptoms of PAH but do not treat the cause. Thus, there is a need for novel drugs that target the underlying pathological causes of PAH. PAH is a multi-factorial, but one key contributor is the …
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Regulation of suppressor of cytokine signalling 3 expression by the pro-inflammatory cytokine (IL-1beta) in vitro and inflammatory stimuli in vivo
… or other stimuli which affect the homeostasis of the organism. IL-6-induced expression of acute phase protein genes in the liver is tightly regulated through both IL-6-induced feedback inhibitors and the activity of pro-inflammatory cytokines such as tumor necrosis factor alpha and …
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The effect of cAMP elevation on intracellular signalling pathways in prostate epithelial cells
Chronic IL-6 signalling contributes to the pathophysiology of many diseases including prostate cancer. Relevant to prostate cancer is the ability of the pro-inflammatory cytokine IL-6 to activate the oncogenic signalling protein STAT3, thus inhibition of STAT3 activation is a popular avenue of …
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Differentielle Genexpression in der Insulinoma-Zelllinie RINm5F nach Stimulation mit Leptin
Leptin, a cytokine secreted by the white adipose tissue, decreases food intake via hypothalamic pathways and is a major regulator of energy homoestasis. Leptin has also important peripheral effects, such as the attenuation of insulin secre-tion from pancreatic islets. Leptin signals through the …
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Investigation of the cAMP-mediated inhibitory mechanism on the signalling pathways of 2 cytokines: IL-6 and leptin in endothelial cells
There is a wealth of evidence to support the anti-inflammatory properties of the prototypical second messenger cyclic-AMP (cAMP), notably with regard to endothelial function. Many studies have shown that cAMP can limit vascular permeability by enhancing barrier function and reducing …
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Mechanisms of microglia induced retinal degeneration
… therapies.Evidence has suggested the immune profile and inflammatory etiology in patientswith retinal neurodegenerative diseases. Microglial activation is known to play animportant role in neuroinflammation and neurodegeneration. However, there is adebate on whether microglial activation is the …
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Negative Regulation der Oncostatin M-vermittelten Signaltransduktion
To avoid overshooting cytokine signalling with possible pathological consequences, the duration as well as the intensity of the activated signal transduction pathways are tightly regulated. The importance of the feedback inhibitor suppressor of cytokine signalling 3 (SOCS3) in inhibition of the …
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Role of IL-6/gp130-dependent signalling pathways in hepatocytes during liver regeneration and inflammation
… initiates cellular events started by induction of JAK kinases resulting in Ras/Erk-mediated signalling and activation of STAT transcription factors, particularly STAT3. Within the present studies the role of the Interleukin-6 (IL-6) receptor gp130 in hepatocytes was investigated in terms of …