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Showing 1 to 20 of 886 for “"suppressor"”.
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Tumor suppressor pathway in myocardium
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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p14ARF : A p53-Independent Tumor Suppressor
… overexpression of the p14<sup>ARF</sup> tumor suppressor in the cancerous HCT116 parent cell line along with its p53 knockout derivative. Our results indicate that p14 indeed has a very potent effect in the presence of p53, and a substantial effect in its absence.</p> <p>In the clonogenicity …
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Investigation of candidate imprinted tumour suppressor genes
Imprinting is an epigenetic phenomenon that silences one allele of a gene, so that expression in one or more cell types is exclusively monoallelic, and dependent on parental origin. Approaches used to identify novel imprinted genes rely on characteristic features such as the clustering of imprinted …
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Role of the ARF Tumor Suppressor in Osteoclasts
The ARF tumor suppressor is upregulated upon oncogenic stress. ARF can suppress cell proliferation in both p53-dependent and -independent mechanisms. We have focused on ARF's ability to suppress protein synthesis in a p53-independent manner. Given that protein synthesis and the cell cycle are …
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Functional Analysis of the Tumor Metastasis Suppressor, NDRG1
Metastasis suppressors regulate multiple steps during the process of dissemination of tumor cells from primary sites to distant organs, while they do not affect the growth of the primary tumor. Previously, we identified NDRG1 (N-myc downstream regulated gene 1) as a tumor metastasis suppressor gene …
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Characterization of the Murine Macrophage Suppressor Factor (Msf)
… aspects of the immune process. Macrophage suppressor factor (MSF) is a lymphokine produced in the mouse spleen and is present in plasma. The in vitro target cell is the macrophage. The macrophage does not phagocytize as effectively in the presence of MSF. It was previously shown that the …
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Prolyl Isomerase Pin1 Is a Conditional Tumor Suppressor
… suggest Pin1 may function as a conditional tumor suppressor.</p></p>
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Studies of the PTEN tumour suppressor in endometrial cancer.
Somatic mutations in the PTEN gene (Phosphatase and Tensin Homologue Deleted on Chromosome Ten) have been found in many types of cancer, but most frequently in cancer of the endometrium.The PTEN gene encodes a D3 lipid phosphatase of the second messenger phosphatidylinositol 3,4,5-trisphosphate …
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The Role of LKBI Tumor Suppressor in Endometrial Cancer
… observed in Peutz Jegher women, many tumor suppressors have been found to have a much broader role in cancer than would have been predicted on the tumor spectrum associated with the hereditary syndrome. The studies that comprise this dissertation work first demonstrate that in addition to …
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Structure of the LKB1-STRAD-MO25 tumour suppressor complex
A landmark study published over ten years ago established a link between mutations of the LKB1 gene and the Peutz-Jeghers cancer syndrome. Since then, much effort has been devoted to understanding the functional roles of the protein encoded by the LKB1 gene. LKB1 is a Ser/Thr kinase that is …
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Developing nanobodies to stabilise the tumour suppressor protein p16INK4a
The tumour suppressor protein p16INK4a (p16) is a cyclin-dependent kinase (CDK) inhibitor that plays a key role in the regulation of the cell cycle by controlling the progression of cells through the G1 to S phase transition. Dysregulation of the protein through deletion, silencing or mutation of …
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Retroviral-Medicated Transfer of Suppressor tRNA Genes Into Human Cells
… mutations may be to introduce genes expressing suppressor tRNA that recognize the premature stop codon, insert the appropriate amino acid, and allow translation of a full-length, functional protein. Human opal arginine suppressor tRNA genes that encode the structural portion of the tRNA and …
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The Tumor Suppressor BRCA1 in IP3R Calcium Signaling and Apoptosis
… including binding to proto-oncogenes and tumor suppressors to regulate cell death. Here we show that the IP3R binds to the tumor suppressor BRCA1. BRCA1 binds directly to the IP3R and causes destabilization of the IP3R closed state resulting in an increased open probability and increased calcium …
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In Vitro Evidence For A Spleen-Derived Macrophage Suppressor Factor
… This appears to be due to a splenic suppressor factor which inhibits phagocytosis by macrophages. An in vitro assay was developed which used monolayer cultures on microscope cover slips and direct microscopic examination to quantify two parameters of phagocytosis: 1) percentage of …
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Negative regulation of gene expression by the tumor suppressor p53
The tumor suppressor p53 inhibits the expression of a substantial number of genes whose protein products serve to promote cell survival or cell cycle progression, thereby ensuring efficient execution of p53-dependent apoptosis, cell-cycle arrest or senescence. Furthermore, p53-mediated repression …
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Stability, folding and evolution of the tumour suppressor protein p16.
The tumour suppressor protein, p16, is a member of the INK4 family of inhibitors of the cyclin D-dependent kinases 4 and 6 in the pRb pathway of eukaryotic cell cycle. The 156-amino acid protein consists of four ankyrin (ANK) repeats. The ANK repeat is a ubiquitous 33-residue sequence motif that …
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Regulation of the Arf tumor suppressor by E2F transcription factors
… for cellular proliferation. The Arf tumor suppressor is a key regulator of p53, and causes activation of p53-mediated cell cycle arrest or apoptosis in the presence of unrestrained proliferation due to cellular oncogenes. E2F has been predicted to be a regulator of Arf, but the exact …
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Functional analysis of the Neurofibromatosis Type II tumor suppressor gene
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Biology, 1999.
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