Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 22 for “"superoxide radical"”.
-
Detection of Biologically Relevant Anions by Fluorescence and NIR Molecular Probes
… probe for rapid quantification of the superoxide radical-forming pro-oxidant activity of flavonols. This assay was then successfully applied in quantifying the pro-oxidant activity of different tea leaves. The second part has demonstrated that a near infrared (NIR) active mixed-valence …
-
Engineered human cytochrome c : investigation of superoxide and protein-protein interaction and application in bioelectronic systems
… as well as with respect to the reaction with the superoxide radical and the selected proteins sulfite oxidase from human and fungi bilirubin oxidase. All three interaction partners are studied here for the first time with human cyt c and with mutant forms of cyt c. A further aim is the …
-
Lignin biodegradation: reduced oxygen species
… fungi, I demonstrated that C. versicolor exports superoxide radical and hydrogen peroxide during lignin degradation, into the lignolytic medium. Results presented in this study indicate that a correlation between the concentration of extracellular superoxide radical in the medium and the extent of …
-
Molecular basis of MPTP-induced Parkinson's disease
… of the neurotoxin MPTP, was found to generate superoxide radical (⋅O₂⁻) during its autoxidation process. The generation of ⋅O₂⁻ was detected by their ability to reduce ferricytochrome c. Superoxide dismutase (SOD) inhibited this reduction in a dosedependent manner. The rate of reduction of …
-
Electrochemical studies of lithium-oxygen reactions for lithium-air battery applications
… electrolyte solvents on the stability of the superoxide radical produced on planar glassy carbon and Au electrodes. It was found that the fraction of oxygen reduction reaction current attributable to superoxide generation exhibits a solvent-invariant potential dependence on carbon, with a …
-
Subacute immunotoxic effects of the environmental contaminants 7,12-dimethylbenzanthracene (DMBA), hexachlorocyclohexane (lindane), and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on spleen and pronephros cellularity and morphology and functional activity of macrophages contained in these hematopoietic organs in the cichlid fish tilapia (<i>Oreochromis niloticus</i>)
… of chemical-treated fish. However, neither superoxide radical production or phagocytosis of splenic or pronephric macrophages was inhibited in either DMBA, lindane, or TCDD exposed fish. Results of this study indicate that depressed total cell number in fish hematopoietic organs may be a …
-
Synthesis And Characterization Of Nickel Complexes With Relevance To Nickel Acireductone Dioxygenase And Nickel Superoxide Dismutase
… acireductone dioxygenase (Ni-ARD) and Ni(II) superoxide dismutase (Ni-SOD). Acireductone dioxygenases (ARDs) are a unique set of enzymes found in the methionine salvage pathway that catalyze the oxidation reaction of acireductone (1, 2-dihydroxy-3-oxo-5-(methylthio)pent-1-ene). These enzymes …
-
Mechanistic insights on the merits and limitations of advanced treatment processes for removal of contaminants of emerging concern
… key reactive oxygen species (ROS) i.e. hydroxyl radical (•OH) and superoxide radical anion (O2•-) in degrading PFAS with some studies demonstrating their effectiveness while others claiming the contrary. This dissertation aims to provide mechanistic insights into the treatment of PFAS and other …
-
Formulation of improved media for isolation and cultivation of Campylobacter fetus
… toxic derivatives of oxygen, such as the superoxide radical and hydrogen peroxide.
-
Design of potential antiprotozoal daunorubicin derivatives
… into the DNA double hel~x and stimulation of superoxide radical formation. In order to discover the contribution of these mechanisms to trypanocidal activity, the trypanocidal potency of a series of daunorubicin analogues was assessed in vitro. The ability of these analogues to intercalate …
-
NQO1-Bioactivatable Drugs at the Interface of Cancer Metabolism and the DNA Damage Response
… futile redox cycle to generate massive levels of superoxide radical to induce extensive DNA oxidative base damage, single strand breaks and poly(ADP-ribose) polymerase 1 (PARP1)-driven depletion of intracellular NAD+. However, tumor cell NADPH and glutathione (GSH) biogenesis can attenuate the …
-
Antioxidant activity and phytochemical evaluations of selected medicinal plants
… nodosa was shown to have potent DPPH radical scavenging activity (IC50 = 48.75 ± 7.00 μg/ml). Activity-guided fractionation resulted in the isolation of three principal antioxidant compounds; acteoside, angoroside C and angoroside A. Acteoside (yield = 1.21%, IC50 = 15.2 μM) appeared …
-
The chemical speciation of potential dermally-absorbed copper-based antiinflamatory drugs
… species is important for tissue solubility. The superoxide radical the superoxide dismutase (SOD)-like activity of the copper complexes of these ligands was investigated. The results showed that the SOD-like activity of the present complex systems was too negligible for them to be considered as …
-
The effects of cellular quiescence on the antioxidant defense enzymes of bovine embryonic lung fibroblasts: a survey
… basis of aging is still unclear. Free radicals such as the superoxide radical (O₂⁻) and the hydroxyl radical (OH⁻), formed in biological oxidation reactions may be responsible for cellular aging. Because of the high reactivity of the O₂⁻ and the OH⁻ they can produce extensive damage to …
-
Antioxidant Intervention With manganese(Iii)-Salophen in the Selenite Cataract Model: Implications for Cataract Disease
… We have investigated a novel antioxidant, the superoxide scavenger Mn(III)-salophen, as a therapeutic agent in the selenite cataract model. Mn(III)-salophen has been shown to protect E. coli colonies against oxidative stress but was untested in a eukaryotic system. A total dose of 300 mmol/kg, …
-
Investigation of hypoxia and hyperglycaemia mediated DNA damage in human endothelial cells.
… and HUVEC size stay the same. A change in superoxide radical production in hypoxic conditions alone emphasises the important contribution of hypoxia in the pathogenesis of endothelial damage. Further investigation reveals a role for HIF-1a in the development of endothelial DNA damage which …
-
Towards electrochemical diagnostics of biochemical free radical species in aqueous microliter volumes
Reactive oxygen species (ROS) are free radicals often implicated in disease states. In probing related enzyme processes, reactant consumption must be minimized. Levitated drops show potential as microreactors where radicals are present as reactants or products. Solid/liquid interfaces are absent or …
-
Mechanistic Studies of the Structure-Photostability Relationship of Organic Conjugated Polymers
… that lead to photodegradation of CPs, the radical mechanism is initiate by generation of superoxide radical anion and the other mechanism is initiated by singlet oxygen. C8-diCN-PPV has a lower LUMO level compared to RO-diCN-PPV, yet photodegrades more quickly. RO-diCN-PPV and C8-diCN-PPV …
-
Mechanism of Action of Antipsychotics, Haloperidol and Olanzapine in vitro
… PC-12 cells. HP was found to be ineffective as a superoxide radical scavenger but appeared to be a potent scavenger of hydroxyl radicals with a rate constant of ~6.78 X 109 M-1s-1. Olz on the other hand was found to scavenge hydroxyl radical at a rate of 34.1 X 109 M-1s-1. This was shown using the …
-
Role of Angiotensin II Type 2 Receptors in Oxidative Stress and Inflammation
… between oxidative stress, in particular superoxide radicals, and RAS system in terms of renal sodium handling is not known. In order to determine the possible interaction between RAS system and oxidative stress in terms of sodium homeostasis and role of AT2 receptors in oxidative stress …
Page 1 of 2