Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 245 for “"superoxide dismutase"”.
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Characterization of superoxide dismutase from Actinomyces
… strain ii E1S.25D produce a Mn-containing superoxide dismutase (MnSOD). Actinomyces, once classified as yeast based on their morphology, are saprophytic organisms found among the normal flora of the mouth but can act as endogenous pathogens resulting in gingivitis and actinomycosis. The …
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Characterising the Drosophila extracellular superoxide Dismutase gene
… the key components of this machinery is the<br/>superoxide dismutase (SOD) family of enzymes which regulate ROS levels by<br/>scavenging the ROS superoxide. Mammals have three distinct SOD enzymes each<br/>responsible for managing superoxide levels in different cellular compartments. …
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Extracellular Superoxide Dismutase Protects Cardiomyocytes During Hyperoxia
… in mice with a transgene (TG) for extracellular superoxide dismutase (EC-SOD) or with the EC-SOD gene knockout (KO). Adult EC-SOD mice and their wild type littermates and EC-SOD KO mice and their wild type littermates were exposed to 100% oxygen for 6 hours and for 72 hours, and the hearts were …
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Catalase, Superoxide Dismutase, and Staphylococcus Aureus Virulence
… itself against microbial attack is by producing superoxide radicals and hydrogen peroxide. These oxygen-free radicals are known to kill bacterial cells. The aim of this study was to investigate the relationship between catalase and superoxide dismutase (the enzymes that degrade hydrogen peroxide …
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In vivo metal substitution in bacteroides superoxide dismutase
… of various growth conditions on the type of superoxide dismutase (SGD) formed anaerobically in three Bacteriodes species was studied. B. fragilis, B. distasonis, and B. thetaiotaomicron were grown in ironâ restricted media with or without manganese supplementation. Iron availability was …
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Computational Evaluation of Mechanistic Pathways of Action of Superoxide Dismutase
… studies on thermodynamics of dismutation of superoxide anion radicals (O<sup>2-</sup>) to hydrogen peroxide and molecular oxygen was conducted with various theoretical models using a variety of basis sets. The computational models include semi-empirical, Hartree-Fock and density functional …
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Role of Manganese Superoxide Dismutase in Chemotherapy-induced Oxidative Stress
… lymphoma is mediated by an increase in manganese superoxide dismutase (MnSOD) protein expression and accumulation of hydrogen peroxide (H₂O₂). Findings indicate that the rapamycin-induced cytostatic effect is characterized by increased levels of MnSOD and H₂O₂, and is necessary for the full growth …
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Cloning and expression of cambialistic Bacteroides fragilis superoxide dismutase gene
A gene coding for the cambialistic superoxide dismutase (SOD) was isolated from a LambdaGEM-11 genomic library of <i>Bacteroides fragilis</i>. In order to generate a complete genomic library, <i>B. fragilis</i> genomic DNA was partially digested with the restriction endonuclease Sau3AI and was …
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Superoxide Dismutase Activity During Thermal Stress and Recovery of Staphylococcus Aureus
The superoxide dismutase (SOD) activity during growth, following injury and during the recovery of Staphylococcus aureus was examined. During the growth cycle of S. aureus MF-31, the SOD activity decreased during the lag phase, paralleled a concurrent increase in cell counts during the logarithmic …
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Catalase, superoxide dismutase, and hemolysin in the virulence of Listeria monocytogenes
… monocytogenes were examined for catalase, superoxide dismutase (SOD), and listeriolysin O (LLO) activities. The two strains having the lowest catalase activities also possessed the lowest SOD activities. Exogenous hydrogen peroxide was added to suspensions of four L. monocytogenes strains; …
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The characterization of cysteine protease 4 and superoxide dismutase 6 in Trichomonas vaginalis
… This paper also examined the role of iron superoxide dismutase 6 (TvFeSOD6) in resistance to metronidazole, the current drug used for Trichomoniasis infections. Of the two types of resistance, aerobic resistance may occur due to a high concentration of intracellular oxygen which can …
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Catalase and Superoxide Dismutase Activity in Response to Elevated Oxygen in Drosophila Melanogaster
… in the 50% atmosphere, but neither catalase nor superoxide dismutase showed evidence of induction beyond the normal level. The lack of increased production of these protective oxido-reductases in an environment presumed to produce more free radicals may be responsible for the reduced lifespan of …
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The potential of the superoxide dismutase inhibitor, diethyldithiocarbamate as an adjuvant to radiotherapy
… One of these potentially toxic radicals, superoxide (O₂⁻) can be generated as a result of ionizing radiation, and if not adequately removed can proceed to cause cell damage. Superoxide dismutase (SOD) is one of the key enzymes involved in the defence against oxygen toxicity. SOD activity …
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Engineering Estrogen Receptor-Based Gene Switches and a Superoxide Dismutase for Therapeutic Applications
… E. coli selection system based on resistance to superoxide toxicity was used in a directed evolution approach to enhance the catalytic efficiency of a rationally designed mutant manganese superoxide dismutase enzyme exhibiting greatly reduced product inhibition and low catalytic efficiency …
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Thermal and denaturation studies of the time-resolved fluorescence decay of superoxide dismutase
… of the single tryptophan (Trp) residue of human superoxide dismutase (HSOD) over a wide range of temperatures and at different denaturant concentrations. First, it is demonstrated that the center of the lifetime distribution can characterize the average deactivation environment of the excited …
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A Role for BDNF-Trkb Signaling in the Modulation of Superoxide Dismutase-1 Expression
Superoxide dismutase-1 (SOD1) has been implicated in the pathogenesis of familial amyotrophic lateral sclerosis (fALS), a degenerative motor neuron disease more commonly known as Lou Gehrig’s disease. The mechanism by which it causes degeneration and the extent of its involvement are currently …
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The effect of macromolecular crowding on the structure of the protein complex superoxide dismutase
… crowding on the size of a protein complex, superoxide dismutase (SOD). Crowding was induced using 400 MW polyethylene glycol (PEG), triethylene glycol (TEG), methyl-alpha-glucoside (alpha-MG) and trimethylamine N-oxide (TMAO). Parallel small angle neutron scattering (SANS) and small angle …
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Isolation, reconstitution, and molecular cloning of the manganese-containing superoxide dismutase from Deinococcus radiodurans
The superoxide dismutase from a radiation-resistant bacterium Deinococcus radiodurans has been purified to electrophoretic homogeneity. The superoxide dismutase has a specific activity of 3300 units/mg and an apparent molecular mass of 43,000 daltons. The enzyme contains 1.5 gram-atom of manganese …
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Investigation of catalase and superoxide dismutase from Mycobacterium avium, M. intracellulare and M. scrofulaceum
Catalase and superoxide dismutase, but not peroxidase activity was detected in cell-free extracts of Mycobacterium avium, M. intracellulare and M. scrofulaceum (MAIS). The M. scrofulaceum isolates had the highest catalase activity, while both M. avium and M. intracellulare had significantly lower …
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Synthesis And Characterization Of Nickel Complexes With Relevance To Nickel Acireductone Dioxygenase And Nickel Superoxide Dismutase
… acireductone dioxygenase (Ni-ARD) and Ni(II) superoxide dismutase (Ni-SOD). Acireductone dioxygenases (ARDs) are a unique set of enzymes found in the methionine salvage pathway that catalyze the oxidation reaction of acireductone (1, 2-dihydroxy-3-oxo-5-(methylthio)pent-1-ene). These enzymes …
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