Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"supercomplex"”.
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Effect of experimental complex III deficiency on respiratory chain assembly and function
… disorders, especially possible changes in supercomplex formation, the specific aims of this thesis were to investigate CIII assembly and supercomplexes in a mouse model harboring the Bcs1l mutation c.232A>G. In homozygotes, the mutation results in a progressive CIII deficiency mimicking the …
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Electron cryomicroscopy structures of respiratory supercomplexes from alphaproteobacteria suggest mechanisms to enhance catalysis and to prevent deactivation of respiratory complex I
… form oligomeric membrane assemblies known as supercomplexes. Even though they are found throughout nature and several physiological consequences are associated with their depletion, it is not clear why they have evolved and what their selective advantage is. While the role of mitochondrial …
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Characterization of alternative enzymes in bacterial respiration
… to co-purify with the aa3 oxidase as a stable supercomplex. This supercomplex was characterized and its components were identified. The supercomplex was initially isolated in the detergent, dodecyl maltoside (DDM), but did not have a homogenous population. Therefore, efforts were made to …
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The Bc(1) Complex of Rhodobacter Sphaeroides and Its Integration Into the Photosynthetic Chain
… electron transfer chain in Rb. sphaeroides, supercomplex model and heterogeneity model were examined with wild type and overproducer strains of Rb. sphaeroides. No fixed stoichiometry of photosynthetic components, and the dependence of the equilibrium constants on the light intensity and the …
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The Molecular Anatomy of Mitochondrial Disease: Identification and Characterisation of Novel Nuclear-Encoded Mitochondrial Disease Genes
… COX subunits, intermediates, monomeric and supercomplex COX species, as well as isolated COX enzymatic deficiency. Stable expression of COA7WT in patient fibroblasts by lentivirus-mediated complementation rescued COX abundance, the quantities of its affected subunits, subassembly and …
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GPCR Activation of the G Protein-Gated Inward-Rectifier Potassium Channel
… that GIRK channels form a macromolecular supercomplex with Gαi-coupled receptors and G proteins, allowing released Gβγ to bind to and activate GIRK by proximity. However the evidence for the existence of the complex remains controversial. In the first part of my thesis, I challenge the …
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Amylin, tissue hypoxia and metabolic dysregulation in diabetic heart and liver
… ETC activity was associated with increased supercomplex formation. This was accompanied by an elevation in FAO. These responses are typical of an acute stress response to hypoxia in the liver. To understand the impact of hypoxia on metabolism against a background of T2DM, a milder rat model …
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Student teacher views on the role of the university
… The student teachers of this study, as part of a supercomplex world, recognize the university-knowledge relationship but stand for a new nature of this relationship.
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Regulation of the mTORC1 growth pathway by amino acids
… lysosomal transmembrane protein. SLC38A9 forms a supercomplex with Ragulator, the Rag GTPases and the v-ATPase and is necessary for mTORC1 activation by amino acids, particularly arginine. Overexpression of the full-length protein or just its Ragulator-binding domain makes mTORC1 signaling …
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Structural Studies into the Mechanism and Organisation of Mammalian Respiratory Complex I
… information for complex I and its constituent supercomplexes from immortalised human cell lines remains limited despite its potential as a system for studying human complex I disease mutations and its unique metabolic adaptations. Chapter 2 uses structural data from two high-resolution cryo-EM …
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Collaboration in Higher Education: Theorising Co-Creation for Inclusive Learning and Teaching Praxis
… is and what universities could be in these supercomplex, competitive, silo-ised times. What is proposed is the creation of collaborative third spaces, both physical and metaphorical, that allow people to come together – to be with – and to dialogically co-create knowledge: a sustainable …
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Structural examination of trypanosomatid tubulin-binding cofactors and pteridine reductase 1 inhibition
… assembly-competent aß-tubulin heterodimer from a supercomplex between TBCC, TBCD, TBCE and both tubulin subunits. Full-length recombinant Trypanosoma brucei and Leishmania major tubulin-binding TBCC were degraded and crystallisation could not be achieved. However, crystals of a truncated TBCC …