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Showing 1 to 20 of 38 for “"sulfoximine"”.
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Neue heterocyclische Sulfoximine
… describes the synthesis of novel heterocyclic sulfoximines. Being aware the enormous application potential of heterocyclic sulfoximines (e.g. as bioactive compounds or as ligands), we were inspired to expand the existing protocols for the synthesis of this class of compounds. In the first part …
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Synthese neuartiger Sulfoximine für die asymmetrische Metallkatalyse
In this work various beta-hydroxysulfoximines was synthesized. We proved their catalytic applicability in asymmetric phenyl transfer reactions onto aldehydes. Enantiomerically enriched diarylmethanols have been prepared by catalyzed asymmetric phenyl transfer reactions onto aromatic aldehydes with …
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Chirale Sulfonimidamide und Sulfoximine : Synthese, Strukturuntersuchungen und Anwendungen
… and the determination of the basicity of a bissulfoximine. In the first part the preparation of enantio- and diastereomerically pure sulfonimidamides bearing either an oxazolidinyl or a cyclohexylamino moiety is described, as well as the synthesis of enantiopure oxazolinyl-derivatized thioureas …
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Oxidation & 1, 5-hydride shift of sulfoximine derivatives
… REQUEST.] Oxidation of N-alkyl and N-aryl sulfoximines and 1,5-hydride shift of S-alkenyl sulfoximines have been studied. Oxidation of N-alkyl sulfoximines using dimethyldioxirane gave sulfones and nitroso derivatives. A mechanism for the process was proposed. Thermal isomerization and …
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Modular asymmetric synthesis of functionalized azaspirocycles based on the sulfoximine auxiliary
… was achieved in three steps from cyclic allylic sulfoximines. The first key step was a titanium-mediated gamma-hydroxyalkylation of named sulfoximines. In the course of this reaction two new stereogenic centers and a double bond were created diastereoselectively. The key step for installation of …
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Cyclische Alpha- und Ortho-Lithio-S-Phenyl-Sulfoximine : Synthese, Funktionalisierung und Umlagerung
… the synthesis of different substituted cyclic sulfoximines suitable for the use as ligands in the asymmetric 1,4-addition. This aim was tried to achieve through synthesis of different substituted cyclic sulfoximines for the use as chiral nontransferable ligands in the stoichometric conjugate …
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Asymmetric synthesis of medium-sized carbocycles spirocycles and oxabicycles via ring closing metathesis sufoximine substituted trienes and dihydropyran derivates
… of medium-sized carbocycles. In this project, sulfoximine-substituted trienes were proven to be excellent parent compounds for the selective synthesis of Z-configured medium sized carbocycles. The formation of sulfoximine-substituted trienes, key intermediates of the described synthesis, was …
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Use of methionine sulfoximine to dissect the role of glutamine synthetase and glutamine in progression of acute liver failure
<p>Methionine sulfoximine (MSO) is a modified amino acid and a well characterized irreversible inhibitor of glutamine synthetase (GS) enzyme. Glutamine is synthesized by GS enzyme and it is the most abundant amino acid in the body. Glutamine is required by immune cells for generation, propagation …
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Application of sulfonimidoyl substituted allyltitanium (IV) complexes to the asymmetric synthesis of alkenyloxiranes, 2,3-dihydrofurans, tetrahydrofurans, unsaturated proline analogues and allylic alcohols
… were obtained through aminoalkylation of the sulfoximine substituted allyl (trisdiethylamino) titanium (IV) complexes with the N-tert-butylsulfonyl imino ester. Activation of sulfoximines through methylation, of the sulfoximine group follwed by Cl substitution, and subsequent DBU-mediated, …
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Synthese neuer C 1-symmetrischer Monosulfoximine und deren Anwendung als Liganden in der asymmetrischen Katalyse
… development of a new class of C1-symmetric monosulfoximines and their application as ligands in asymmetric catalysis. The main question, with which the research was concerned, is whether a ligand which does not possess C2-symmetry and has only one chiral sulfoximine unit can transfer chirality …
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Asymmetrische Synthese funktionalisierter Homoallyl- und Homopropargylalkohole mittels der Sulfoximin-Route
… and enantiomeric pure allylic alcohols. Via the sulfoximine-route by Gais et al. new chiral homoallyllic alcohols were synthesized. Elimination of the sulfoximine-group lead to optically pure homopropargylic alcohols. Via Nickel-catalysed cross-coupling reactions (homogenoes and heterogenoes …
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Asymmetrische Synthese 3-substituierter 4-Methylenproline und Untersuchungen zur Metathese mit vinylischen Sulfoximinen
… prolines was developed. (S)-N,S-dimethyl-S-phenylsulfoximine was tansformed via an addition, elimination, isomerization route (AEI-route) into the corresponding mixture of E and Z allylic sulfoximines. This conversion yields in all cases more than 85% of the mixture. The ratio between the two …
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Synthesis of new sulfoximines for asymmetric synthesis and pseudopeptides
Sulfoximines have attracted attention due to their applicability as chiral auxiliaries, ligands in asymmetric catalysis, and building blocks in pseudopeptides. A number of approaches have been investigated for their synthesis, which allows the preparation of various derivatives in a relatively …
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Asymmetrische Synthese von bicyclischen Alpha-Aminosäuren durch intramolekulare Pauson-Khand-Reaktion von l-Alkenylsulfoximinen und Festphasensynthese mit Allylsulfoximinen
… enantiomerically pure (S)-N,S-Dimethyl-S-phenylsulfoximine allylic sulfoximines could easily be prepared in 55-70% yield following a well established addition elimination isomerization route. A regio and diastereoselective allylation of N-tert-Butysulfonyliminoester with titanated allylic …
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Asymmetrische Synthese von allylischen Alkoholen mittels Palladium-katalysierter asymmetrischer Transformation von allylischen Carbonaten und Synthese neuer Sulfoximin-Phosphane
… this thesis is devoted to the development of new sulfoximine ligands and methods of their synthesis. On this occasion, interesting new classes of sulfoximines, alpha-(N-sulfoximido) phosphines, phosphine oxides and phosphonates, were synthesized from N-vinyl sulfoximines. These new sulfoximines …
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Planar chirale Metallocene
… processes. In the course of this PhD thesis, the sulfoximine unit was established as a new chiral ortho-directing group for ferrocenes. By variation of the metal fragment and other structural properties of a published chiral ligand, a cyclopentadienylrhenium(I)tricarbonyl complex was identified as …
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