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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 76 for “"sulfonamides"”.
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Synthesis of functionalised sulfonamides
Sulfonamides are important therapeutic agents and have a diverse array of biological functions in biology and medicine. Their means of synthesis has often involved the use of unstable sulfonyl chloride species; however, recent research has established pentafluorophenyl (PFP) sulfonate esters as a …
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The crystal landscape and cocrystallization of primary aromatic sulfonamides
This thesis is focused on primary benzenesulfonamides. They have been structurally characterised and analysed for common structural motifs present in the solid state. A systematic investigation of their cocrystallization with a range of neutral, zwitterionic and ionic coformers has been carried, …
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Optimal Analysis of Sulfonamides From Biological Matrices Using Supercritical Fluids
… preparation procedures for the isolation of sulfonamides, as well as, to determine the applicability of employing on-line nitrogen selective and mass spectrometric detection methods. The first phase of this research investigated the effect of temperature and pressure on the supercritical …
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Application of organic acid functionalized cellulose for batch and aqueous two-phase extraction of sulfonamides from different matrices
… globally, with fluoroquinolones, macrolides and sulfonamides being commonly prescribed. Sulfonamides, which form the basis of several sulfa drugs, have significant applications in both medicinal and synthetic organic chemistry. While these substances are effective in their intended uses, their …
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Reductive cleavage of N-substituted benzenesulfonamides and p-sulfamylbenzoic acid
… on the nitrogen atom and on the ring of sulfonamides in the Birch reduction of aromatic sulfonamides, especially with respect to the amount of thiol formed, in the hope that information concerning the initial cleavage step might be discerned.</p>
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Preparation of N,N'-Dialkyl bis(diamino) diphenylmethanes and N,N'-Dialkyl bis(diamino) benzophenones: preparation of B-hydroxy sulfonamides and B-hydroxy sulfinamides
… Alkylation was accomplished by reacting the sulfonamides with 2.2 equivalents of dry potassium hydroxide in hexamethylphosphoramide at 75°, followed by addition of 2.2 equivalents of alkylating agent (methyl iodide, ethyl iodide, and benzyl chloride) to afford 70-84% of the alkylated …
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Fundamental studies on 2,4,6-trichlorophenyl sulfonate esters
… esters in the synthesis of sulfonamides. The sulfonamide unit is an important structural motif due to its frequent occurrence in a range of pharmaceuticals, particularly antibiotics. Sulfonamides can be readily synthesised from pentafluorophenyl (PFP) sulfonate esters and as …
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Novel synthetic methodology employing transition metal catalysed reactions of α-diazo-β-keto sulfonamides and α-cyano-α-diazoacetates; the impact of substituents on the reaction pathway
… this thesis is the reactivity of α-diazo-β-keto sulfonamides, α-cyano-α-diazoacetates and α-arylsulfonyl-α-diazoacetates employing rhodium and copper catalysts. While the α-diazo-β-keto sulfonamides were specifically designed to investigate rhodium- and copper-catalysed intramolecular C–H …
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New applications of heteroarylzinc nucleophiles
… 2 details a new approach to the synthesis of sulfonamides using aryl and heteroaryl organozine nucleophiles. Chapter 3 describes ongoing collaborative efforts to discover new malaria therapeutics where the synthetic method developed in Chapter 2 facilitated access to targeted compounds. …
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Transport and fate of veterinary sulfonamide antibiotics in soil
… in detail: i) sorption and transport of the sulfonamides in structured and homogeneous soil columns, ii) distribution of the applied antibiotics in runoff and soil layer on sloped fields, iii) comparing the transport processes between sulfadimethoxine and sorbable/unsorbable tracers. In the …
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The mechanistic basis of susceptibility and resistance to the antitubercular drug para-aminosalicylic acid
… is a known antagonist of antifolates, namely sulfonamides. Since PAS was shown to act similarly to PABA in folate biosynthesis, PAS-sulfonamide interactions were tested against a panel of bacterial pathogens. PAS could antagonize sulfonamides in all of these organisms. HIV-infected individuals …
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Removals of sulfonamide and trimethoprim antibiotics in municipal wastewater by biological treatment processes
… revealed to be the key mechanism for eliminating sulfonamides and trimethoprim during aerobic biological treatment process compared to relatively insignificant removal by sorption to sludge. The removals of sulfonamides by aerobic bioreactors were shown to be consistently greater than that of …
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Structural and Kinetics Studies of the Enzyme Dihydropteroate Synthase and the Implications for Antibiotic Resistance
… bacterial resistance has limited the efficacy of sulfonamides, and an increasing trend in drug resistance has heightened the need for development of new therapeutics. Although drug resistance has severely limited the clinical use of sulfonamides, the folate pathway, and DHPS in particular, remain …
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